Methyl 3-bromo-4-methylbenzoate

Product Name: Methyl 3-bromo-4-methylbenzoate
CAS No.: 104901-43-1
Chemical Name: Methyl 3-bromo-4-methylbenzoate
Synonyms: Methyl 3-bromo-4-met;METHYL 4-BROMO-M-TOLUATE;METHYL 3-BROMO-P-TOLUATE;METHYL 3-BROMO-4-METHYLBENZOATE;3-BROMO-4-METHYL METHYL BENZOATE;Methyl3-Bromo-4-methylbenzoate>3-BroMo-p-toluic acid Methyl ester;4-BROMO-M-TOLUIC ACID METHYL ESTER;Methyl 3-bromo-4-methylbenzoate ,98%;4-BROMO-3-METHYLBENZOIC ACID METHYL ESTER
CBNumber: CB8724371
Molecular Formula: C9H9BrO2
Formula Weight: 229.07
MOL File: 104901-43-1.mol

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Methyl 3-bromo-4-methylbenzoate Property

Melting point:: 38-44 °C(lit.)
Boiling point:: 130°C/0.1mmHg(lit.)
Density: 1.433±0.06 g/cm3(Predicted)
refractive index: 1.5570 to 1.5610
Flash point:: >230 °F
storage temp.: Inert atmosphere,Room Temperature
solubility: Soluble in dimethyl sulfoxide.
form: clear liquid
color: Colorless to Light orange to Yellow
InChI: InChI=1S/C9H9BrO2/c1-6-3-4-7(5-8(6)10)9(11)12-2/h3-5H,1-2H3
InChIKey: MASRAGFWFYHMFI-UHFFFAOYSA-N
SMILES: C(OC)(=O)C1=CC=C(C)C(Br)=C1
CAS DataBase Reference: 104901-43-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 2916399090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: M2181
Product name: Methyl 3-Bromo-4-methylbenzoate
Purity: >98.0%(GC)
Packaging: 5g
Price: $36
Updated: 2025/07/31

TCI Chemical

Product number: M2181
Product name: Methyl 3-Bromo-4-methylbenzoate
Purity: >98.0%(GC)
Packaging: 25g
Price: $107
Updated: 2025/07/31

TRC

Product number: M295525
Product name: Methyl 3-Bromo-4-methylbenzoate
Packaging: 250mg
Price: $55
Updated: 2021/12/16

TRC

Product number: M295525
Product name: Methyl 3-Bromo-4-methylbenzoate
Packaging: 1g
Price: $75
Updated: 2021/12/16

AK Scientific

Product number: B363
Product name: Methyl 3-Bromo-4-methylbenzoate
Packaging: 25g
Price: $52
Updated: 2021/12/16

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Methyl 3-bromo-4-methylbenzoate Chemical Properties,Usage,Production

Chemical Properties

Orange-red solid

Uses

It is a pharmaceutical intermediate.

Synthesis Reference(s)

The Journal of Organic Chemistry, 53, p. 5545, 1988 DOI: 10.1021/jo00258a030

Synthesis

67-56-1

7697-26-9

104901-43-1

The general procedure for the synthesis of methyl 3-bromo-4-methylbenzoate from methanol and 3-bromo-4-methylbenzoic acid was as follows: 3-bromo-4-methylbenzoic acid (2.0 g, 9.30 mmol) was suspended in methanol (20 ml), and sulfuric acid (0.04 ml) was added as a catalyst. The reaction mixture was stirred at 60°C for 42 hours. After completion of the reaction, the reaction mixture was concentrated and the residue was dissolved in ethyl acetate. The organic phase was washed with saturated aqueous sodium bicarbonate, dried over anhydrous magnesium sulfate, filtered and concentrated to afford the title compound methyl 3-bromo-4-methylbenzoate as an orange oil (2.25 g, quantitative yield), which could be used for subsequent experiments without further purification.

References

[1] Patent: US2013/237537, 2013, A1. Location in patent: Paragraph 0330-0331
[2] Patent: WO2013/119946, 2013, A1. Location in patent: Paragraph 0198; 0345
[3] Patent: WO2011/107608, 2011, A1. Location in patent: Page/Page column 69
[4] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 23, p. 6442 - 6446
[5] Patent: WO2006/4903, 2006, A2. Location in patent: Page/Page column 125

Methyl 3-bromo-4-methylbenzoate Preparation Products And Raw materials

Raw materials

3-Bromo-4-methylbenzoic acid Ethyl acetate Sulfuric acid

Preparation Products

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Methyl 3-bromo-4-methylbenzoate Suppliers

Americas 1 Belgium 1 China 165 Europe 1 France 1 Germany 5 India 12 Japan 3 United Kingdom 14 United States 28 Global 231

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View Lastest Price from Methyl 3-bromo-4-methylbenzoate manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: Methyl 3-bromo-4-methylbenzoate 104901-43-1
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-30

Career Henan Chemical Co

Product: Methyl 3-bromo-4-methylbenzoate 104901-43-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg,5kg,100kg
Release date: 2019-07-04

104901-43-1, Methyl 3-bromo-4-methylbenzoateRelated Search:

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METHYL 4-BROMO-M-TOLUATE

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METHYL 3-BROMO-4-METHYLBENZOATE

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3-BROMO-4-METHYL METHYL BENZOATE

3-BROMO-4-METHYLBENZOIC ACID METHYL ESTER

4-BROMO-3-METHYLBENZOIC ACID METHYL ESTER

4-BROMO-M-TOLUIC ACID METHYL ESTER

Methyl 3-bromo-4-methylbenzoate ,98%

Methyl 3-bromo-4-met

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3-Bromo-p-toluic acid methyl ester (COOCH3=1)

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Methyl3-Bromo-4-methylbenzoate&gt

104901-43-1

Building Blocks

Carbonyl Compounds

C8 to C9

Organic Building Blocks

Esters

Acids & Esters

Bromine Compounds

Aromatic Esters