ChemicalBook > CAS DataBase List > AG 1478

AG 1478

Product Name: AG 1478
CAS No.: 175178-82-2
Chemical Name: AG 1478
Synonyms: AG 1517;AG 1478;SU 5271;WHI-P 79;NSC 669364;PD-153,035;COMPOUND 32;Tyrphostin AG;AG 1478 USP/EP/BP;TYRPHOSTIN AG 1517
CBNumber: CB8751920
Molecular Formula: C16H14ClN3O2
Formula Weight: 315.75
MOL File: 175178-82-2.mol

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AG 1478 Property

Melting point:: 180 - 183°C
storage temp.: 2-8°C
solubility: 0.1 M HCl: soluble <0.4 mg/mL
form: Pale yellow solid
color: Off-white
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 658552
Product name: AG 1478
Packaging: 5mg
Price: $192
Updated: 2025/07/31

Sigma-Aldrich

Product number: 658548
Product name: InSolution? AG 1478
Packaging: 1mg
Price: $98.6
Updated: 2025/07/31

Sigma-Aldrich

Product number: T4182
Product name: Tyrphostin AG 1478
Purity: ≥98%
Packaging: 1mg
Price: $74.38
Updated: 2025/07/31

Sigma-Aldrich

Product number: T4182
Product name: Tyrphostin AG 1478
Purity: ≥98%
Packaging: 5mg
Price: $246
Updated: 2025/07/31

American Custom Chemicals Corporation

Product number: KIN0001450
Product name: AG 1478
Purity: 95.00%
Packaging: 1G
Price: $798
Updated: 2021/12/16

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AG 1478 Chemical Properties,Usage,Production

Description

AG-1478 (175478-82-2; base) is a potent and selective inhibitor of the EGFR kinase (IC50 = 3 nM). Inhibits proliferation of a variety human cancer cell lines.1,2 AG-1478 reduces pulmonary fibrosis in a rat model.3?Cell permeable.

Uses

Tyrphostin AG 1478 has been used as epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor to study its effect on desmoid cell mobility in boyden chamber motility assays. It has also been used to inhibit phosphorylation of c-Met by exogenous transforming growth factor α in epidermoid carcinoma cell line A431.

Uses

A highly potent and specific EGFR tyrosine kinase inhibitor with an IC50 of 3 nM.

Uses

Tyrphostin AG 1478 is a potent and selective inhibitor of EGFR.

Definition

ChEBI: Tyrphostin AG 1478 is a member of the class of quinazolines that is quinazoline substituted by methoxy groups at positions 6 and 7 and a (3-chlorophenyl)nitrilo group at position 4. It acts as an epidermal growth factor receptor antagonist. It has a role as an epidermal growth factor receptor antagonist, an antineoplastic agent, a geroprotector and an antiviral agent. It is a member of quinazolines, an aromatic ether and a member of monochlorobenzenes.

General Description

Highly potent and specific inhibitor of the epidermal growth factor (EGF) receptor tyrosine kinase (IC₅₀ = 3 nM). Much higher concentrations are required for inhibition of the kinase activity of the closely related HER2 (neu/erb-B2) receptor (IC₅₀ >100 μM), the platelet-derived growth factor (PDGF) receptor (IC₅₀ >100 μM), and p210^Bcr-Abl (IC₅₀ >50 μM). Its mechanism of inhibition likely mimics that of the related compound, 4-(3-chloroanilino)quinazoline (CAQ), a competitive inhibitor with respect to ATP.

Biochem/physiol Actions

Primary TargetEpidermal growth factor receptor kinase

References

[1] Y HAN. Tyrphostin AG 1478 preferentially inhibits human glioma cells expressing truncated rather than wild-type epidermal growth factor receptors.[J]. Cancer research, 1996, 56 17: 3859-3861.
[2] G PARTIK. Inhibition of epidermal-growth-factor-receptor-dependent signalling by tyrphostins A25 and AG1478 blocks growth and induces apoptosis in colorectal tumor cells in vitro.[J]. Journal of Cancer Research and Clinical Oncology, 1999, 125 7: 379-388. DOI:10.1007/s004320050290
[3] ANNETTE B. RICE . Specific Inhibitors of Platelet-Derived Growth Factor or Epidermal Growth Factor Receptor Tyrosine Kinase Reduce Pulmonary Fibrosis in Rats[J]. American Journal of Pathology, 1999, 155 1: Pages 213-221. DOI:10.1016/s0002-9440(10)65115-2

AG 1478 Preparation Products And Raw materials

Raw materials

Preparation Products

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AG 1478 Suppliers

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175178-82-2, AG 1478Related Search:

Adapalene ZM 336372 (E)-3-[[[3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYL]PHENYL]-[[(3-DIMETHYLAMINO)-3-OXOPROPYL]THIO]METHYL]THIO]-PROPANOIC ACID, SODIUM SALT Sunitinib Malate RANAKININ NS-398 AG 213 Quinazoline AG 1478 in Solution AG1478HCl,AG-1478,AG 1478 HYDROCHLORIDE Tyrphostin AG 1478 (4-(3-Chloroanilino)-6, 7-dimethoxyquinazoline) AG 1478 EPIDERMAL GROWTH FACT TYRPHOSTIN A51 2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI) AG 1295

NSC 669364

N-[3-CHLOROPHENYL]-6,7-DIMETHOXY-4-QUINAZOLINAMINE

N-(3-CHLOROPHENYL)-N-(6,7-DIMETHOXY-4-QUINAZOLINYL)AMINE

SU 5271

WHI-P 79

TYRPHOSTIN AG 1478

TYRPHOSTIN AG 1517

AG 1478

AG 1517

4-(N-3-CHLOROPHENYL)-AMINO-6,7-DIMETHOXYQUINAZOLINE

4-QUINAZOLINAMINE, N-(3-BROMOPHENYL)-6,7-DIMETHOXY-

InSolution AG 1478 - CAS 175178-82-2 - Calbiochem

AG 1478 - CAS 175178-82-2 - Calbiochem

4-(3-BROMOPHENYLAMINO)-6,7-BIS(METHOXY)QUINAZOLINE

4-[(3-BROMOPHENYL)AMINO]-6,7-DIMETHOXYQUINAZOLINE

4-(3-BROMOPHENYLAMINO)-6,7-DIMETHYLQUINAZOLINE

4-(3-CHLOROANILINO)-6,7-DIMETHOXYQUINAZOLINE

4-(3-CHLOROANILLINO)-6,7-DIMETHOXYQUINAZOLINE

4-(3-BROMOANILINO)-6,7-DIMETHOXYQUINAZOLINE

COMPOUND 32

TYRPHOSTIN AG 1478, 99+%

4-(3-Chloro-benzyl)-6,7-dimethoxy-quinazoline

4-Quinazolinamine,N-(3-chlorophenyl)-6,7-dimethoxy-

N-(3-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine

Tyrphostin AG 1478, Methanesulfonate Salt

InSolution? AG 1478

PD-153,035

Tyrphostin AG

4-[(3-chlorophenyl)methyl]-6,7-dimethoxyquinazoline

AG 1478 USP/EP/BP

AG 1478, EGF receptor tyrosine kinase inhibitor

175178-82-2

174178-82-2

BioChemical

Cell Signaling and Neuroscience

Cell Biology

Kinase/Phosphatase Biology

Epidermal Growth Factor Receptor (EGFR)

Receptor Tyrosine Kinase Inhibitors