1-AZETIDINECARBOXYLIC ACID
- Product Name
- 1-AZETIDINECARBOXYLIC ACID
- CAS No.
- 105443-94-5
- Chemical Name
- 1-AZETIDINECARBOXYLIC ACID
- Synonyms
- 1-AZETIDINECARBOXYLIC ACID;(S)-1-Boc-azetidine-2-carboxamide;1-Boc-(S)-azetidine-2-carboxamide;N-(TERT-BUTOXYCARBONY)-L-AZETIDINE-2-CARBAMIDE;N-(TERT-BUTOXYCARBONYL)-L-AZETIDINE-2-CARBAMIDE;(S)-tert-Butyl 2-carbamoylazetidine-1-carboxylate;tert-butyl (S)-2-carbamoylazetidine-1-carboxylate;tert-butyl (2S)-2-carbamoylazetidine-1-carboxylate;tert-butyl (2S)-2-(aminocarbonyl)azetidine-1-carboxylate;(2S)-2-Carbamoylazetidine-1-carboxylic acid tert-butyl ester
- CBNumber
- CB8783695
- Molecular Formula
- C9H16N2O3
- Formula Weight
- 200.23
- MOL File
- 105443-94-5.mol
1-AZETIDINECARBOXYLIC ACID Property
- Boiling point:
- 355.9±31.0 °C(Predicted)
- Density
- 1.194±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 15.97±0.20(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- FA14216
- Product name
- 1-Azetidine carboxylic acid
- Packaging
- 1mg
- Price
- $105
- Updated
- 2021/12/16
- Product number
- FA14216
- Product name
- 1-Azetidine carboxylic acid
- Packaging
- 2mg
- Price
- $157.5
- Updated
- 2021/12/16
- Product number
- FA14216
- Product name
- 1-Azetidine carboxylic acid
- Packaging
- 5mg
- Price
- $315
- Updated
- 2021/12/16
- Product number
- AS85716
- Product name
- (S)-1-Boc-azetidine-2-carboxamide
- Purity
- 95+% ee
- Packaging
- 1g
- Price
- $335
- Updated
- 2021/12/16
- Product number
- FA14216
- Product name
- 1-Azetidine carboxylic acid
- Packaging
- 10mg
- Price
- $472.5
- Updated
- 2021/12/16
1-AZETIDINECARBOXYLIC ACID Chemical Properties,Usage,Production
Synthesis
51077-14-6
105443-94-5
General procedure for the synthesis of tert-butyl (S)-2-carbamoylazetidine-1-carboxylate from 1-Boc-L-acridine-2-carboxylate: Boc-L-2-azetidinecarboxylic acid (compound 8a, 2.91 g, 14.45 mmol) and triethylamine (Et3N, 2.01 mL, 14.45 mmol) were dissolved in tetrahydrofuran (THF, 33 mL) in tetrahydrofuran (THF, 33) and cooled to -10 °C. Under stirring, pre-cooled ethyl chloroformate was slowly added dropwise, and stirring was continued for 20 min by keeping the reaction temperature at -10 °C. Subsequently, 28% ammonia (NH4OH, 3.21 mL) solution was added and the reaction system was gradually warmed up to room temperature. Upon completion of the reaction, the THF solvent was removed by distillation under reduced pressure. The residue was partitioned between ethyl acetate (EtOAc) and water, and the organic phase was separated, dried over anhydrous magnesium sulfate (MgSO4), filtered and the solvent was concentrated under reduced pressure to give compound 9a as a white crystalline solid (2.36 g, 82% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 1.34 (s, 9H), 1.96-1.98 (m, 1H), 2.30-2.39 (m, 1H), 3.75-3.80 (m, 2H), 4.37 (dd, J = 9.1, 5.5 Hz, 1H), 7.11 (s, 1H), 7.34 (s. 1H).
References
[1] Patent: WO2007/23382, 2007, A2. Location in patent: Page/Page column 70
[2] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 10, p. 3037 - 3040
[3] Patent: WO2014/141065, 2014, A1. Location in patent: Page/Page column 50
1-AZETIDINECARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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