ChemicalBook > CAS DataBase List > tert-butyl (4-bromobutyl)carbamate

tert-butyl (4-bromobutyl)carbamate

Product Name: tert-butyl (4-bromobutyl)carbamate
CAS No.: 164365-88-2
Chemical Name: tert-butyl (4-bromobutyl)carbamate
Synonyms: tert-Butyl 4-bromobutylcarbamate;Boc-NH-C4-Br;tert-Butyl (4-bromobutyl);N-Boc 4-broMobutan-1-aMine;4-(BOC-AMINO)BUTYL BROMIDE;ert-butylN-(4-bromobutyl)carbamate;N-(tert-Butoxycarbonyl)-1-broMobutan-4-ylaMine;4-(BOC-AMINO)BUTYL BROMIDE ISO 9001：2015 REACH;(4-bromo-butyl)-carbamic acid tert-butyl ester;4-(Boc-aMino)butyl broMide technical, >=90% (AT)
CBNumber: CB8972527
Molecular Formula: C9H18BrNO2
Formula Weight: 252.15
MOL File: 164365-88-2.mol

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tert-butyl (4-bromobutyl)carbamate Property

Boiling point:: 308.8±25.0 °C(Predicted)
Density: 1.228
storage temp.: 2-8°C
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form: Low-Melting Solid
pka: 12.76±0.46(Predicted)
color: White to Pale Yellow
InChI: InChI=1S/C9H18BrNO2/c1-9(2,3)13-8(12)11-7-5-4-6-10/h4-7H2,1-3H3,(H,11,12)
InChIKey: GKGFAEREWWZBKY-UHFFFAOYSA-N
SMILES: C(OC(C)(C)C)(=O)NCCCCBr

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Safety

Hazard Codes: Xi
Risk Statements: 41
Safety Statements: 26-39
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 90303
Product name: 4-(Boc-amino)butyl bromide
Purity: technical,≥90%(AT)
Packaging: 500mg
Price: $125
Updated: 2025/07/31

Sigma-Aldrich

Product number: 90303
Product name: 4-(Boc-amino)butyl bromide
Purity: technical,≥90%(AT)
Packaging: 2.5g
Price: $318.5
Updated: 2025/07/31

TRC

Product number: B601525
Product name: 4-(t-Boc-amino)-1-butylBromide
Packaging: 1g
Price: $185
Updated: 2021/12/16

TRC

Product number: B601525
Product name: 4-(t-Boc-amino)-1-butylBromide
Packaging: 10g
Price: $950
Updated: 2021/12/16

AK Scientific

Product number: 8351AA
Product name: 4-(Boc-amino)butyl bromide
Packaging: 250mg
Price: $131
Updated: 2021/12/16

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tert-butyl (4-bromobutyl)carbamate Chemical Properties,Usage,Production

Chemical Properties

Off-White Low Melting Solid

Uses

4-(Boc-amino)butyl bromide can be used:

For the synthesis of N-Boc-aminoalkoxyphenyl derivatives, precursor to pharmacophore elements for the treatment of glaucoma.
For the synthesis of various aloperine derivatives with potential application as anti-HIV agents.
For the modification of 4,5,6,7-tetrabromobenzotriazole (TBB) derivatives to generate improved CK2 inhibitors.

reaction suitability

reagent type: cross-linking reagent

Synthesis

75178-87-9

164365-88-2

General procedure for the synthesis of tert-butyl N-(4-bromobutyl) carbamate from 4-(N-tert-butoxycarbonylamino)-1-butanol: 4-(N-tert-butoxycarbonylamino)-1-butanol (1.06 g, 5.788 mmol) was dissolved in anhydrous THF (54 mL), followed by the addition of triphenylphosphine (2.86 g, 10.92 mmol, 1.9 equiv) . Carbon tetrabromide (3.62 g, 10.92 mmol, 1.9 eq.) was added slowly with stirring. The reaction mixture was stirred at room temperature for 3 h. After stirring, the reaction mixture was filtered through a diatomaceous earth pad to remove by-products and the filter cake was washed with ether. The filtrate was concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel fast column chromatography (eluent: hexane/ethyl acetate, 3:1) to afford tert-butyl N-(4-bromobutyl)carbamate (1.73 g, quantitative yield) as a white solid.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 2, p. 1151 - 1155
[2] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 11, p. 1156 - 1161
[3] Patent: WO2017/53360, 2017, A1. Location in patent: Paragraph 0154
[4] Patent: WO2017/96045, 2017, A1. Location in patent: Paragraph 00884
[5] Patent: WO2012/9309, 2012, A1. Location in patent: Page/Page column 58

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Raw materials

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View Lastest Price from tert-butyl (4-bromobutyl)carbamate manufacturers

Sach biotech Co.,Ltd

Product: 4-(BOC-AMINO)BUTYL BROMIDE 164365-88-2
Price: US $30.00-27.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 5mt
Release date: 2025-06-09

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-(BOC-AMINO)BUTYL BROMIDE 164365-88-2
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-25

Career Henan Chemical Co

Product: 4-(BOC-AMINO)BUTYL BROMIDE 164365-88-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95-99%
Supply Ability: 1ton
Release date: 2019-12-30

164365-88-2, tert-butyl (4-bromobutyl)carbamateRelated Search:

tert-butyl N-[3-[methoxy(methyl)amino]-3-oxopropyl]carbamate 7-AMINO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER Iodoform cis-2,6-Dimethyl-4-oxo-piperidine-1-carboxylic acid tert-butyl ester HEXAHYDRO-PYRROLO[3,4-B]PYRROLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER cis-2-(tert-Butoxycarbonylamino)-1-cyclopentanecarboxylic acid 2-Boc-5-hydroxy-2-azaspiro[3.3]heptane (3R,5S)-3,5-DiMethylMorpholine hydrochloride Carbamic acid, [(3R,4S)-4-hydroxy-3-pyrrolidinyl]-, 1,1-dimethylethyl ester, rel- tert-Butyl 3-oxo-6-chloro-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate tert-butyl 3-hydroxyazepane-1-carboxylate TERT-BUTYL 4-(4-FORMYL-1,3-THIAZOL-2-YL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE tert-butyl 2-(chloromethyl)-1H-benzimidazole-1-carboxylate TERT-BUTYL PROPIOLATE TERT-BUTYL N-(3-THIENYL)CARBAMATE (4-IODO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER TERT-BUTYL 4-AMINO-3-FLUOROPIPERIDINE-1-CARBOXYLATE tert-butyl 6-bromo-2H-pyrido[3,2-b][1,4]oxazine-4(3H)-carboxylate

Carbamic acid,N-(4-bromobutyl)-, 1,1-dimethylethyl ester

N-(4-BroMobutyl)carbaMic Acid 1,1-DiMethylethyl Ester

N-(tert-Butoxycarbonyl)-1-broMobutan-4-ylaMine

N-Boc 4-broMobutan-1-aMine

tert-Butyl 4-bromobutylcarbamate

4-(Boc-aMino)butyl broMide technical, >=90% (AT)

tert-Butyl (4-bromobutyl)

ert-butylN-(4-bromobutyl)carbamate

4-(BOC-AMINO)BUTYL BROMIDE ISO 9001：2015 REACH

Boc-NH-C4-Br

4-(BOC-AMINO)BUTYL BROMIDE

(4-bromo-butyl)-carbamic acid tert-butyl ester

164365-88-2

BrCH24NHCO2CCH33

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