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kaurenoic acid

Product Name: kaurenoic acid
CAS No.: 6730-83-2
Chemical Name: kaurenoic acid
Synonyms: NSC 339145;kaurenoate;Cunabic acid;kaurenoic acid;Kaurenoic acid-RM;Kauren-19-oic acid;ent-kaur-16-en-19-oicaci;Kaurane-16-ene-18-oic acid;(-)-Kaur-16-en-18-oic acid;ent-Kaur-16-en-19-oic acid
CBNumber: CB91316121
Molecular Formula: C20H30O2
Formula Weight: 302.45
MOL File: 6730-83-2.mol

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kaurenoic acid Property

Melting point:: 171-172 °C
Boiling point:: 426.6±34.0 °C(Predicted)
Density: 1.10±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: DMF: 10 mg/ml; DMSO: 25 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml; Ethanol: 10 mg/ml
form: A solid
pka: 4.70±0.40(Predicted)
color: White to off-white

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SMB00177
Product name: Kaurenoic acid
Purity: ≥95% (LC/MS-ELSD)
Packaging: 1mg
Price: $259
Updated: 2025/07/31

Sigma-Aldrich

Product number: PHL84229
Product name: Kaurenoic acid
Purity: phyproof? Reference Substance
Packaging: 10MG
Price: $614
Updated: 2025/07/31

Cayman Chemical

Product number: 28957
Product name: Kaurenoic Acid
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 28957
Product name: Kaurenoic Acid
Packaging: 5mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 28957
Product name: Kaurenoic Acid
Packaging: 10mg
Price: $142
Updated: 2024/03/01

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kaurenoic acid Chemical Properties,Usage,Production

Description

Kaurenoic acid is a diterpene that has been found in C. langsdorffii and has diverse biological activities, including anticancer, antibacterial, antioxidant, and anti-inflammatory properties. It is cytotoxic to 22Rv1 and LNCaP prostate, HT-29, HCT116, SW480, and SW620 colon, and MCF-7 breast cancer cells with IC₅₀ values ranging from 15.03 to 48.87 μg/ml. Kaurenoic acid is active against S. epidermidis, S. capitis, E. faecalis, and S. haemolyticus in vitro (MICs = 6.25-12.5 μg/ml). Kaurenoic acid (50 and 100 mg/kg) reduces colonic myeloperoxidase (MPO) activity and malondialdehyde (MDA) levels in a rat model of acetic acid-induced colitis, as well as colonic tissue damage, leukocytic infiltration, and submucosal edema when administered at a dose of 100 mg/kg.

Chemical Properties

White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from plants such as Acanthopanax Cortex (1% content) and Bletilla striata leaves.

Uses

ent-Kaurenoic Acid can be used in biological study. Kinetic profile of guaco syrup metabolites like coumarin, 7-hydroxycoumarin, o-coumaric acid, kaurenoic acid can be performed for identification of alternative route of coumarin metabolism in human plasma.

Definition

ChEBI: An ent-kaurane diterpenoid that is ent-kauran-19-oic acid in which a double bond is present at position 16(17); exhibits anticancer and anti-HIV 1 activity.

in vivo

Kaurenoic acid (1-10 mg/kg, i.g., single dose) reduces peritonitis and pain induced by lipopolysaccharides (HY-D1056) in mice^[2].
Kaurenoic acid (as a diterpene compound) is the main active ingredient in the root bark extract of A. senegalensis that exhibits anticonvulsant effects in mice^[3].

Animal Model:	Mice induced by LPS^[2]
Dosage:	1, 3, 10 mg/kg; single dose
Administration:	i.g.
Result:	Inhibited LPS-induced mechanical and thermal hyperalgesia, suppressed MPO activity, regulated the redox state of mouse paws, inhibited the production of pro-inflammatory/pain cytokines (such as TNF-α, IL-1β, and IL-33), and enhanced the production of anti-inflammatory/analgesic cytokine IL-10.

References

[1] L.A.F. PAIVA . Anti-inflammatory effect of kaurenoic acid, a diterpene from Copaifera langsdorffii on acetic acid-induced colitis in rats[J]. Vascular pharmacology, 2002, 39 6: Pages 303-307. DOI: 10.1016/s1537-1891(03)00028-4
[2] GENEIVE E. HENRY . Kaurene diterpenes from Laetia thamnia inhibit the growth of human cancer cells in vitro[J]. Cancer letters, 2006, 244 2: Pages 190-194. DOI: 10.1016/j.canlet.2005.12.022
[3] A. C. F. SOARES. Variability of the antibacterial potential among analogue diterpenes against Gram-positive bacteria: considerations on the structure–activity relationship[J]. Canadian Journal of Chemistry, 2019, 62 1. DOI: 10.1139/cjc-2018-0369

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Raw materials

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View Lastest Price from kaurenoic acid manufacturers

Henan Fengda Chemical Co., Ltd

Product: kaurenoic acid 6730-83-2
Price: US $8.00-6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-23

Shanghai Standard Technology Co., Ltd.

Product: Kaurenoic acid 6730-83-2
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-12-25

Career Henan Chemical Co

Product: kaurenoic acid 6730-83-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%HPLC
Supply Ability: 10 tons
Release date: 2020-01-09

6730-83-2, kaurenoic acidRelated Search:

ISOEGOMAKETONE Deacetyltaxol Continentalic acid Carboxyatractyloside DARUTOSIDE 10-Deacetylbaccatin III dipotassium dihydrogen 15alpha-hydroxy-2beta-[[2-O-isovaleryl-3,4-di-O-sulphonato-beta-D-glucopyranosyl]oxy]kaur-16-ene-18,19-dioate DARUTIGENOL β-Elemonic Acid ISOBAVACHALCONE RUBUSOSIDE Rebaudioside A Steviol wedeloside glucosilsteviol Rebaudioside D kaurenoic acid STEVIOL METHYL ESTER

kaurenoic acid

(-)-Kaur-16-en-18-oic acid

Cunabic acid

Kaurane-16-ene-18-oic acid

ent-Kaur-16(17)-en-19-oic acid

ent-Kaur-16-en-19-oic acid

NSC 339145

Kaur-16-en-18-oic acid,(4a)-

Kauren-19-oic acid

(4R,4aS,6aS,9R,11aR,11bS)-4,11b-dimethyl-8-methylenetetradecahydro-6a,9-methanocyclohepta[a]naphthalene-4-carboxylic acid

ent-kaur-16-en-19-oicaci

(4R,6aS,9R,11bS)-4,11b-dimethyl-8-methylenetetradecahydro-6a,9-methanocyclohepta[a]naphthalene-4-carboxylic acid

(5Β,8α,9Β,10α)-Kaur-16-en-18-oic acid

kaurenoate

Kaur-16-en-18-oic acid, (4α)-

(4R,4aS,6aS,9S,11aR,11bS)-4,11b-Dimethyl-8-methylenetetradecahydro-6a,9-methanocyclohepta[a]naphthalene-4-carboxylic acid

Kaurenoic acid-RM

Kaurenoic acid, 10 mM in DMSO

6730-83-2