ChemicalBook > CAS DataBase List > 5-Hydroxyindole

5-Hydroxyindole

Product Name
5-Hydroxyindole
CAS No.
1953-54-4
Chemical Name
5-Hydroxyindole
Synonyms
1H-INDOL-5-OL;5-INDOLOL;5-Hydroxyindoline;NSC 87503;INDOL-5-OL;5-hdroxyindole;5-HYDROXYINDOLE;hydroxy-5indole;Hydroxy-5 indole;Hydroxyindole,98%
CBNumber
CB9151600
Molecular Formula
C8H7NO
Formula Weight
133.15
MOL File
1953-54-4.mol
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5-Hydroxyindole Property

Melting point:
106-108 °C(lit.)
Boiling point:
245.66°C (rough estimate)
Density 
1.1475 (rough estimate)
refractive index 
1.5260 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility 
38g/l
form 
Crystalline Needles or Powder
pka
9.98±0.40(Predicted)
color 
beige
Sensitive 
Light Sensitive
BRN 
112349
InChI
InChI=1S/C8H7NO/c10-7-1-2-8-6(5-7)3-4-9-8/h1-5,9-10H
InChIKey
LMIQERWZRIFWNZ-UHFFFAOYSA-N
SMILES
N1C2=C(C=C(O)C=C2)C=C1
CAS DataBase Reference
1953-54-4(CAS DataBase Reference)
NIST Chemistry Reference
Indol-5-ol(1953-54-4)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
3
RTECS 
NM2430000
HazardClass 
IRRITANT, KEEP COLD
HS Code 
29339990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H31859
Product name
5-Hydroxyindole
Purity
97%
Packaging
1g
Price
$68.5
Updated
2024/03/01
TCI Chemical
Product number
H0252
Product name
5-Hydroxyindole
Purity
>98.0%(GC)
Packaging
100mg
Price
$18
Updated
2024/03/01
TCI Chemical
Product number
H0252
Product name
5-Hydroxyindole
Purity
>98.0%(GC)
Packaging
1g
Price
$57
Updated
2024/03/01
Alfa Aesar
Product number
L00858
Product name
5-Hydroxyindole, 98+%
Packaging
1g
Price
$50.65
Updated
2024/03/01
Alfa Aesar
Product number
L00858
Product name
5-Hydroxyindole, 98+%
Packaging
5g
Price
$185.65
Updated
2024/03/01
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5-Hydroxyindole Chemical Properties,Usage,Production

Chemical Properties

beige to brown crystalline needles or powder

Uses

• ;Reactant for preparation of (oxoimidazolidinyl/oxopyrimidinyl)benzenesulfonates as antitumor agents and tubulin inhibitors1• ;Reactant for preparation of anthranilic acids2• ;Reactant for preparation of indole compounds as dopamine D2 receptor antagonists3• ;Reactant for preparation of naphthalimide- or carbazole-containing human β-adrenoceptor ligands4• ;Reactant for preparation of melanins as nature-inspired radioprotectors5• ;Reactant for preparation of 5-vinyl-3-pyridinecarbonitriles as PKCθ inhibitors6

Uses

5-Hydroxyindole is a hydroxylated indole used as a building block in the preparation of various pharmaceutical compounds such as indole based neurochemicals. 5-Hydroxyindole is a metabolite of Tryptophan (T894800). 5-Hydroxyindole displayed weak inhibitory activity on human melanoma tyrosinase. 5-Hydroxyindole also showed inhibition of serotonin transport by blood platelets.

Definition

ChEBI: 5-hydroxyindole is a member of the class of hydroxyindoles that is 1H-indole in which the hydrogen at position 5 has been replaced by a hydroxy group. It has a role as a human metabolite.

Synthesis Reference(s)

Journal of the American Chemical Society, 76, p. 5579, 1954 DOI: 10.1021/ja01651a001
The Journal of Organic Chemistry, 49, p. 4833, 1984 DOI: 10.1021/jo00199a017

5-Hydroxyindole Preparation Products And Raw materials

Raw materials

3-Methyl-4-nitrophenol potassium ferricyanide Palladium Benzyl bromide N,N-Dimethylformamide dimethyl acetal

Preparation Products

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5-Hydroxyindole Suppliers

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View Lastest Price from 5-Hydroxyindole manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
5-Hydroxyindole 1953-54-4
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-04-22
Wuhan Circle Star Chem-medical Technology Co.,Ltd
Product
5-Hydroxyindole 1953-54-4
Price
US $0.00-0.00/g
Min. Order
1g
Purity
99
Supply Ability
1000
Release date
2025-01-23
Hebei Mujin Biotechnology Co.,Ltd
Product
5-Hydroxyindole 1953-54-4
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-10-09

1953-54-4, 5-HydroxyindoleRelated Search:

Indole-3-acetic acid Indole-3-butyric acid Chrysin Indometacin 5-HYDROXYOXINDOLE 2,3-DIHYDROINDOL-5-OL 5-Methoxyindole-3-carboxaldehyde 5,6-Dimethoxyindole 5-Methoxyindole 5-METHOXY-2-METHYLINDOLE 5-BENZYLOXYGRAMINE Melatonine DL-5-HYDROXYTRYPTOPHAN 5-Benzyloxyindole 5-Methoxytryptamine 7-HYDROXYINDOLE 5-METHOXY-DL-TRYPTOPHAN 4-HYDROXYINDOLE

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  • 1953-54-4
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  • Building Blocks
  • Indoles
  • Simple Indoles
  • Heterocyclic Building Blocks
  • Heterocycle-Indole series
  • Building Blocks
  • C7 to C9
  • Chemical Synthesis
  • Heterocyclic Building Blocks
  • Indoles
  • Simple Indoles
  • pharmacetical
  • Indole
  • indole derivative
  • Indoles and derivatives
  • blocks
  • IndolesOxindoles