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ZYMOSAN A

Product Name
ZYMOSAN A
CAS No.
58856-93-2
Chemical Name
ZYMOSAN A
Synonyms
ZYMOSAN;ZYMOSAN A;A zymosans;Zymosans A;Zymosan type A;YEAST POLYSACCHARIDES;Zymosan, Pre-activated;anticomplementary factor;Zymosan, Saccharomyces cerevisiae,;Zymosan A fromSaccharomycecerevisiae
CBNumber
CB9165106
Molecular Formula
n.a.
Formula Weight
0
MOL File
Mol file
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ZYMOSAN A Property

RTECS 
ZI2750000
storage temp. 
2-8°C
solubility 
Chloroform: 100 μg/ml; DMSO: 200 μg/ml; Ethanol: 100 μg/ml
form 
Powder
color 
off-white to light brown
biological source
Saccharomyces cerevisiae
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
22-24/25-36-26
WGK Germany 
3
F 
10
HS Code 
3913900099
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Z4250
Product name
Zymosan A from Saccharomyces cerevisiae
Purity
for inducing inflamatory response
Packaging
1g
Price
$213
Updated
2025/07/31
Sigma-Aldrich
Product number
Z4250
Product name
Zymosan A from Saccharomyces cerevisiae
Purity
for inducing inflamatory response
Packaging
5g
Price
$887
Updated
2025/07/31
Cayman Chemical
Product number
21175
Product name
Zymosan A
Packaging
250mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
21175
Product name
Zymosan A
Packaging
500mg
Price
$84
Updated
2024/03/01
Sigma-Aldrich
Product number
Z4250
Product name
Zymosan A from Saccharomyces cerevisiae
Purity
for inducing inflamatory response
Packaging
250mg
Price
$69.8
Updated
2025/07/31
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ZYMOSAN A Chemical Properties,Usage,Production

Uses

Zymosan A from Saccharomyces cerevisiae has been used:

  • as a positive control to determine the activation of complement cascade
  • for respiratory burst (RB) assay
  • to assess its effects on performance, immunity, heat shock protein and apoptosis related gene expressions of dairy cows under heat stress (HS)
  • a stimulating agent in Krebs-Ringer phosphate (KRP) medium
  • to induce thermal hyperalgesia in mice

Biochem/physiol Actions

Zymosan is prepared from yeast cell wall and consists of protein-carbohydrate complexes. It is used to induce experimental sterile inflammation. In macrophages, zymosan-induced responses include the induction of proinflammatory cytokines, arachidonate mobilization, protein phosphorylation, and inositol phosphate formation. Zymosan A also raises cyclin D2 levels suggesting a role for the latter in macrophage activation besides proliferation. It potentiates acute liver damage after galactosamine injection suggesting that certain types of nonparenchymal cells other than Kupffer cells are involved in zymosan action. Zymosan A, a 13 beta glucan contributes to the development of organic dust-induced respiratory disease.

in vivo

Zymosan A (25.0?mg/kg; IP at 12 and 2?h before IR) mitigates IR-induced intestinal injury in mice[1]. Zymosan A can be used in animal modeling to create peritonitis models.

Induction of peritonitis[2]
Background
Zymosan A can mediate the release of pro-inflammatory cytokines including IL-1β, TNF-α, and HMGB1, inducing an inflammatory response leading to peritonitis.
Specific Modeling Methods
Mice: C57BL/6 ? male ? 3-7 months old
Administration: 100 or 500 mg/kg ? i.p.
Note
(1) ChAT-eGFP mice were randomly divided into two groups, and baseline rectal temperature and electrocardiogram (ECG) were measured in each group before injection.
(2) Preparation of Zymosan A Suspension: Weigh Zymosan A and sterilise for 30 minutes with UV light, add sterile filtered saline and vortex thoroughly, store at room temperature overnight and vortex again before use to ensure thorough mixing.
(3) Rectal temperature and ECG were recorded hourly 4 and 24 hours after Zymosan A injection, respectively.
Modeling Indicators
Phenotypic observation: Hypothermia; cardiac insufficiency, including increased variability of baseline heart rate (HR), moderate slowing of ventricular conduction, and decreased cardiac contractility; and bacterial translocation into the peritoneal cavity and bloodstream.
Correlated Product(s): /
Opposite Product(s): /

Animal Model:20.0?Gy abdominal irradiation (ABI) model in mice[1]
Dosage:25.0?mg/kg, dissolved in NS
Administration:IP; injection at 12 and 2?h before IR
Result:Significantly reduced the degree of bleeding and edema in the intestinal tissue.

ZYMOSAN A Preparation Products And Raw materials

Raw materials

Preparation Products

Ergosterol
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ZYMOSAN A Suppliers

China 185 Europe 3 Germany 2 India 1 Japan 2 Switzerland 3 United Kingdom 5 United States 15 Global 216
BOC Sciences
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Creative Enzymes
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Monomer Polymer & Dajac Labs
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Cayman Chemical Company
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Monomer-Polymer & Dajac Laboratories, Inc.
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View Lastest Price from ZYMOSAN A manufacturers

Career Henan Chemical Co
Product
Zymosan 58856-93-2
Price
US $1.00/kg
Min. Order
1kg
Purity
95%-99%
Supply Ability
1000kg
Release date
2018-12-25

58856-93-2, ZYMOSAN ARelated Search:

TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) TERT-BUTYL ISOCYANIDE N-BUTYLISOCYANIDE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) Benzyl isocyanide Tosylmethyl isocyanide DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) METHYL ISOCYANOACETATE Tris(2,4-pentanedionato)chroMiuM(III) Ferric acetylacetonate SALCOMINE Cupric acetylacetonate Ethyl isocyanoacetate Aluminum acetylacetonate COBALT(II) ACETYLACETONATE 2,4-PENTANEDIONE, SILVER DERIVATIVE 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE ZYMOSAN A OPSONIZING REAGENT,ZYMOSAN A (S CEREVISIAE),BIOPARTICLE OPSONIZING REAGENTS FOR S CEREVISIAE (ZYMOSAN)

  • Zymosan A from Saccharomyces cerevisiae Vetec(TM) reagent grade
  • ZYMOSAN
  • ZYMOSAN A
  • anticomplementary factor
  • Zymosan A fromSaccharomycecerevisiae
  • zymosan A from saccharomyces cerevisiae
  • Zymosan A from saccharomyees cerevisiae
  • YEAST POLYSACCHARIDES
  • ZYMOSAN A FROM SACCHAROMYCES CEREVISAE
  • A zymosans
  • Zymosan type A
  • Zymosans A
  • Zymosan, Saccharomyces cerevisiae,
  • Zymosan, Pre-activated
  • Zymosan A from <i>Saccharomyces cerevisiae</i>
  • 58856-93-2
  • Activity Other
  • Activity
  • BioChemical
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Immune Cell Signaling and Blood
  • Immune System Regulation
  • Phagocytosis