ChemicalBook > CAS DataBase List > 4-Chloro-2,6-diaminopyrimidine

4-Chloro-2,6-diaminopyrimidine

Product Name
4-Chloro-2,6-diaminopyrimidine
CAS No.
156-83-2
Chemical Name
4-Chloro-2,6-diaminopyrimidine
Synonyms
2,4-DIAMINO-6-CHLOROPYRIMIDINE;6-CHLORO-PYRIMIDINE-2,4-DIAMINE;NSC 8818;JACS-156-83-2;TIMTEC-BB SBB004123;4-Chloro-2,6-diamino;DiaMino-6-chloropyriMid;Minoxidil EP Impurity B;Minoxidil EP Impurity 3;oro-2,6-diaminopyrimidine
CBNumber
CB9194300
Molecular Formula
C4H5ClN4
Formula Weight
144.56
MOL File
156-83-2.mol
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4-Chloro-2,6-diaminopyrimidine Property

Melting point:
199-202 °C(lit.)
Boiling point:
199-202 °C
Density 
1.3966 (rough estimate)
vapor pressure 
0.0±1.1 mmHg at 25°C
refractive index 
1.702
Flash point:
218.9±29.6 °C
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
slightly soluble
pka
3.66±0.10(Predicted)
form 
Solid
color 
White to Pale Yellow
Water Solubility 
slightly soluble
BRN 
118455
InChI
InChI=1S/C4H5ClN4/c5-2-1-3(6)9-4(7)8-2/h1H,(H4,6,7,8,9)
InChIKey
QJIUMVUZDYPQRT-UHFFFAOYSA-N
SMILES
C1(N)=NC(Cl)=CC(N)=N1
CAS DataBase Reference
156-83-2(CAS DataBase Reference)
NIST Chemistry Reference
Pyrimidine, 6-chloro-2,4-diamino-(156-83-2)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38
Safety Statements 
26-24/25
WGK Germany 
3
Hazard Note 
Irritant
HS Code 
29335995
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C33204
Product name
2,6-Diamino-4-chloropyrimidine
Purity
98%
Packaging
5g
Price
$54.9
Updated
2025/07/31
Sigma-Aldrich
Product number
C33204
Product name
2,6-Diamino-4-chloropyrimidine
Purity
98%
Packaging
25g
Price
$136.29
Updated
2025/07/31
TCI Chemical
Product number
C0811
Product name
6-Chloro-2,4-diaminopyrimidine
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$52
Updated
2025/07/31
Usbiological
Product number
C4258-60
Product name
6-Chloro-pyrimidine-2,4-diamine
Packaging
5g
Price
$368
Updated
2021/12/16
TRC
Product number
C380950
Product name
6-Chloro-pyrimidine-2,4-diamine
Packaging
100g
Price
$480
Updated
2021/12/16
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4-Chloro-2,6-diaminopyrimidine Chemical Properties,Usage,Production

Chemical Properties

White Cyrstalline Solid

Uses

Melamine and Related Compounds in Dog Food Using GC-MS

Definition

ChEBI: 6-chloro-2,4-pyrimidinediamine (4-Chloro-2,6-diaminopyrimidine) is a member of pyrimidines and an organohalogen compound.

Synthesis

2,4-Diamino-6-hydroxypyrimidine (1.00 g, 7.93 mmol) was added to POCl3 (9 mL) and stirred at 97 ℃ for 17 h. The reaction solution was added to ice water slowly and then stirred at 90 C for 1 h. The pH of this solution was adjusted to 8 with NaOH, and then it was extracted with EtOAC (150 mL 3). The combined organic layers were dried with Na2SO4, filtered, and concentrated to give white solid 4-Chloro-2,6-diaminopyrimidine 0.97 g, yielding 85%.

Purification Methods

It recrystallises from boiling H2O (charcoal) as needles; it also crystallises from Me2CO. [Büttner Chem Ber 36 2232 1903, Roth J Am Chem Soc 72 1914 1950, UV: Brown & Jacobsen J Chem Soc 3172 1962, Beilstein 24 H 318, 25 III/IV 2788.]

References

[1] Molecules, 2017, vol. 22, # 10,

4-Chloro-2,6-diaminopyrimidine Preparation Products And Raw materials

Raw materials

Phosphorus oxitrichloride Sodium Methoxide Guanidine nitrate Methyl cyanoacetate

Preparation Products

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View Lastest Price from 4-Chloro-2,6-diaminopyrimidine manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
4-Chloro-2,6-diaminopyrimidine 156-83-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98
Supply Ability
10000KGS
Release date
2025-11-19
Chongqing Soarwin Technology Co., Ltd
Product
4-Chloro-2,6-diaminopyrimidine 156-83-2
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99.99%
Supply Ability
20 tons
Release date
2025-04-09
Jinan Finer Chemical Co., Ltd
Product
4-Chloro-2,6-diaminopyrimidine 156-83-2
Price
US $5.00/kg
Min. Order
1kg
Purity
≥99%
Supply Ability
1000mt/year
Release date
2023-12-06

156-83-2, 4-Chloro-2,6-diaminopyrimidineRelated Search:

Iminodiacetonitrile 1,3-Diaminoguanidine monohydrochloride 4,6-Dihydroxypyrimidine Iminodiacetic acid Diaminomaleonitrile 4-Amino-6-chloropyrimidine 2,4-Dichloropyrimidine HYDRAZINE 4,4'-Methylenedianiline Difluorochloromethane 4-Chloro-2,6-Diaminopyrimidine-N-Oxide,6-Chloro-2,4-diaminopyrimidine-N-oxide 4-CHLORO-6-MORPHOLIN-4-YLPYRIMIDIN-2-AMINE 6-CHLORO-N4,N4-DIETHYLPYRIMIDINE-2,4-DIAMINE 4-CHLORO-5,6-DIAMINOPYRIMIDINE,6-Chloro-4,5-diaminopyrimidine 2-CHLORO-4,5-DIAMINOPYRIMIDINE Minoxidil 4-Chloropyrimidine 6-CHLORO-N4,N4-DIPROPYL-2,4-PYRIMIDINEDIAMINE

  • 4-DiaMino-6-chloropyriMidine
  • NSC 8818
  • DIAMINO-6-CHLOROPYRIMIDINE, 2,4-(SH)
  • 2,4-DIAMINO-6-CHLOROPYRIMIDINE FOR SYNTH
  • 2,6-DiaMino-4-chloropyriMidine 98%
  • DiaMino-6-chloropyriMid
  • 2,4-Diamino-6-chloropyrimidine,98%
  • 4-Chloro-2,6-diaminopyrimidine, 4-Chloro-2,6-diamino-1,3-diazine
  • 2,4-Diamino-6-chloropyrimidine for synthesis
  • 2-AMINO-6-CHLORO-4-PYRIMIDINYLAMINE
  • Pyrimidine,2,4-diamino-6-chloro-
  • 2,4-Diamino-6-Chloro Pyridine
  • 2,4-DIAMINO-6-CHLOROPYRIMIDINE
  • 2,6-DIAMINO-4-CHLORO PYRIMIDINE
  • 4-Chloro-2-6-Diaminopyrimide
  • 2,4-Diamino-6-chloropyrimidine, 99+%
  • 2,4-Pyrimidinediamine, 6-chloro- (9CI)
  • 6-Chloro-pyrimidine-2,4-diyldiamine, 4-Chloro-2,6-diaminopyrimidine
  • 2,4-DIAMINO-6-CHLOROPYRIMIDINE/ MINOXIDIL
  • 4-CHLORO-2,6-DIAMINOPYRIMIDINE 98%
  • 4-CHLORO-2,6-DIAMINOPYRIMIDINE (2,4-DIAMINO-6-CHLOROPYRIMIDINE)
  • 4-Chloropyrimidine-2,6-diamine
  • 4-Chloro-2,6-diaminopyrimidine,98%
  • 4-Chloro-2,6-diaminopyrimidine ,99%
  • 2,6-Diamino-4-chloropyrimidine,4-Chloro-2,6-diaminopyrimidine
  • 4-Chloro-2,6-diamino
  • 2,6-Diamino-4-chloropyrimidine ,98%
  • 2,6-Diamino-4-chloropyrimidine (Internal Standard)
  • 156-83-2, MFCD00006097, 4-Chloro-2,6-diaminopyrimidine
  • JACS-156-83-2
  • 4-CHLORO-2,6-DIAMINOPYRIMIDINE
  • 6-CHLORO-PYRIMIDINE-2,4-DIAMINE
  • 6-CHLORO-PYRIMIDINE-2,4-DIYLDIAMINE
  • 6-CHLORO-2,4-DIAMINOPYRIMIDINE
  • TIMTEC-BB SBB004123
  • 2,4-Pyrimidinediamine, 6-chloro-
  • 2,4-Pyrimidinediamine,6-chloro-
  • 4-Chloro-2,6-pyrimidinediamine
  • 6-Chlor-2,4-diaminopyrimidin(4-2,6)
  • 6-Chloro-2,4-pyrimidinediamine
  • 6-chloro-4-pyrimidinediamine
  • Minoxidil EP Impurity B
  • 2,6-Diamini-4-chloro pyrimidine
  • 2,4-Diamino-6-chloropyramidine
  • Minoxidil Impurity 2(Minoxidil EP Impurity B）
  • 6-Chloro-2,4-diaminopyrimidine &gt
  • 2,6-Diamino-4-chloropyrimidine (Internal Standard)@1000 μg/mL in Pyridine
  • 156-83-2, MFCD00006097, 4-ChL
  • oro-2,6-diaminopyrimidine
  • 2,4-Diamino-6-chloropyrimidine (2,4-DACP)
  • DIAMINO-6-CHLOROPYRIMIDINE, 2,4-
  • C12193500 2,6-Diamino-4-chloropyrimidine
  • Minoxidil EP Impurity 3
  • 2,4-Diamino-6-Chloropyrimidine 2,4--6-
  • 156-83-2
  • C4H5CIN4
  • HETERO CHLORIDE
  • Pyrimidines