RUBOXISTAURIN HYDROCHLORIDE

Product Name: RUBOXISTAURIN HYDROCHLORIDE
CAS No.: 169939-93-9
Chemical Name: RUBOXISTAURIN HYDROCHLORIDE
Synonyms: LY333531 HCl;Ruboxistaurin HCl;Ruboxistaurin(LY333531HCl);Ruboxistaurin Hydrochloride;Ruboxistaurin HCl(LY333531 );Ruboxistaurin hydrochloride (LY333531);LY 333531 hydrochloride - Ruboxistaurin;LY333531 Hydrochloride(Ruboxistaurin HCl);Ruboxistaurin|||LY333531 HCl|||LY 333531 hydrochloride;(7S)-7-((Dimethylamino)methyl)-22,25-dihydro-11H,21H,31H-6-oxa-1,3(3,1)-diindola-2(3,4)-pyrrolacyclononaphane-22,25-dione hydrochloride
CBNumber: CB9206452
Molecular Formula: C28H29ClN4O3
Formula Weight: 505.02
MOL File: 169939-93-9.mol

More

Less

RUBOXISTAURIN HYDROCHLORIDE Property

alpha: D25 -28.7° (c = 1.0 in ethanol)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO: soluble10mg/mL, clear
form: powder
color: orange-red

More

Less

Safety

WGK Germany: 3

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0693
Product name: LY-333531 hydrochloride
Purity: ≥98% (HPLC)
Packaging: 1mg
Price: $152
Updated: 2024/03/01

Cayman Chemical

Product number: 13964
Product name: LY333531 (hydrochloride)
Purity: ≥98%
Packaging: 1mg
Price: $106
Updated: 2024/03/01

Cayman Chemical

Product number: 13964
Product name: LY333531 (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $311
Updated: 2024/03/01

TRC

Product number: R701525
Product name: RuboxistaurinHydrochloride
Packaging: 0.5mg
Price: $185
Updated: 2021/12/16

Axon Medchem

Product number: Axon2362
Product name: LY333531hydrochloride-Ruboxistaurin
Purity: 99%
Packaging: 5mg
Price: $214.5
Updated: 2021/12/16

More

Less

RUBOXISTAURIN HYDROCHLORIDE Chemical Properties,Usage,Production

Description

LY333531 is an inhibitor of PKCβ (IC₅₀s = 4.7 and 5.9 nM for PKCβ1 and PKCβ2, respectively). It is selective for PKCβ1 and PKCβ2 over PKCα, -γ, -δ, -ε, -ζ, and -η (IC₅₀s = 360, 300, 250, >100,000, and 52 nM, respectively). LY333531 also inhibits glycogen synthase kinase 3β (GSK3β; IC₅₀ = 39.4 nM). It inhibits neutrophil extracellular trap (NET) formation induced by phorbol 12-myristate 13-acetate (PMA; ) in primary human neutrophils when used at a concentration of 1 μM. LY333531 increases the mechanical nociceptive threshold in a rat model of diabetic hyperalgesia induced by streptozotocin (STZ; ).

Uses

A protein kinase C (PKC) β inhibitor, exhibits significant anti-angiogenic activity that reduces the response of vascular endothelial cells to stimulation by vascular endothelial growth factor (VEGF). It is used in treatment of diabetic microvascular comp

Uses

Ruboxistaurin is a protein kinase C (PKC) β inhibitor, exhibits significant anti-angiogenic activity that reduces the response of vascular endothelial cells to stimulation by vascular endothelial growth factor (VEGF). Ruboxistaurin is used in treatment of diabetic microvascular complications.

RUBOXISTAURIN HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

RUBOXISTAURIN HYDROCHLORIDE Suppliers

Canada 1 China 63 India 2 United Kingdom 5 United States 19 Global 90

ShangHai ChuanQian Chemcial Technique Centre

Tel: 15869524721
Email: 3525679403@qq.com
Country: China
ProdList: 4009
Advantage: 58

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

ChemCell Biomedicine Co.,Ltd.

Tel: 020-13556033878 2965585218 13556033878
Fax: 0086-0757-85406358
Email: chemcell@hotmail.com
Country: China
ProdList: 369
Advantage: 52

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: meilunui@163.com
Country: China
ProdList: 4727
Advantage: 58

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

Shanghai Synteam Biochem CO.,ltd

Tel: +86-021-58380978 +86-18017016373
Fax: 021-58380978
Email: info@systeambc.com
Country: China
ProdList: 942
Advantage: 50

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 18112977050
Email: cb6@aikonchem.com
Country: China
ProdList: 16684
Advantage: 50

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 9248
Advantage: 55

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

Pharmacodia (Beijing) Co.,Ltd

Tel: +86-400-851-9921
Fax: +86-10-82826195
Email: sales@pharmacodia.com
Country: China
ProdList: 2317
Advantage: 55

169939-93-9, RUBOXISTAURIN HYDROCHLORIDERelated Search:

Trimethylamine hydrochloride Betaine hydrochloride L-Lysine hydrochloride Dimethylamine hydrochloride RUBOXISTAURIN HYDROCHLORIDE RUBOXISTAURIN 3-Isopropenyl-1-methyl-1H-pyrrole 3,4-Di-1H-indol-3-yl-1H-pyrrole-2,5-dione

Ruboxistaurin Hydrochloride

(9S)-9-[(DiMethylaMino)Methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-DiMethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione Hydrochloride

(S)-9-[(Dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione monohydrochloride

Ruboxistaurin HCl

Ruboxistaurin(LY333531HCl)

LY 333531 hydrochloride - Ruboxistaurin

Ruboxistaurin hydrochloride (LY333531)

Ruboxistaurin HCl(LY333531 )

LY333531 HCl

(7S)-7-((Dimethylamino)methyl)-22,25-dihydro-11H,21H,31H-6-oxa-1,3(3,1)-diindola-2(3,4)-pyrrolacyclononaphane-22,25-dione hydrochloride

LY333531 Hydrochloride(Ruboxistaurin HCl)

Ruboxistaurin|||LY333531 HCl|||LY 333531 hydrochloride

169939-93-9

C28H28N4O3HCl

C28H29N4O3Cl

Amines

Heterocycles

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals