RUBOXISTAURIN HYDROCHLORIDE
- Product Name
- RUBOXISTAURIN HYDROCHLORIDE
- CAS No.
- 169939-93-9
- Chemical Name
- RUBOXISTAURIN HYDROCHLORIDE
- Synonyms
- LY333531 HCl;Ruboxistaurin HCl;Ruboxistaurin(LY333531HCl);Ruboxistaurin Hydrochloride;Ruboxistaurin HCl(LY333531 );Ruboxistaurin hydrochloride (LY333531);LY 333531 hydrochloride - Ruboxistaurin;LY333531 Hydrochloride(Ruboxistaurin HCl);(7S)-7-((Dimethylamino)methyl)-22,25-dihydro-11H,21H,31H-6-oxa-1,3(3,1)-diindola-2(3,4)-pyrrolacyclononaphane-22,25-dione hydrochloride;(9S)-9-[(DiMethylaMino)Methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-DiMethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione Hydrochloride
- CBNumber
- CB9206452
- Molecular Formula
- C28H29ClN4O3
- Formula Weight
- 505.02
- MOL File
- 169939-93-9.mol
RUBOXISTAURIN HYDROCHLORIDE Property
- alpha
- D25 -28.7° (c = 1.0 in ethanol)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- DMSO: soluble10mg/mL, clear
- form
- powder
- color
- orange-red
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- SML0693
- Product name
- LY-333531 hydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 1mg
- Price
- $152
- Updated
- 2024/03/01
- Product number
- 13964
- Product name
- LY333531 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $106
- Updated
- 2024/03/01
- Product number
- 13964
- Product name
- LY333531 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $311
- Updated
- 2024/03/01
- Product number
- R701525
- Product name
- RuboxistaurinHydrochloride
- Packaging
- 0.5mg
- Price
- $185
- Updated
- 2021/12/16
- Product number
- Axon2362
- Product name
- LY333531hydrochloride-Ruboxistaurin
- Purity
- 99%
- Packaging
- 5mg
- Price
- $214.5
- Updated
- 2021/12/16
RUBOXISTAURIN HYDROCHLORIDE Chemical Properties,Usage,Production
Description
LY333531 is an inhibitor of PKCβ (IC50s = 4.7 and 5.9 nM for PKCβ1 and PKCβ2, respectively). It is selective for PKCβ1 and PKCβ2 over PKCα, -γ, -δ, -ε, -ζ, and -η (IC50s = 360, 300, 250, >100,000, and 52 nM, respectively). LY333531 also inhibits glycogen synthase kinase 3β (GSK3β; IC50 = 39.4 nM). It inhibits neutrophil extracellular trap (NET) formation induced by phorbol 12-myristate 13-acetate (PMA; ) in primary human neutrophils when used at a concentration of 1 μM. LY333531 increases the mechanical nociceptive threshold in a rat model of diabetic hyperalgesia induced by streptozotocin (STZ; ).
Uses
A protein kinase C (PKC) β inhibitor, exhibits significant anti-angiogenic activity that reduces the response of vascular endothelial cells to stimulation by vascular endothelial growth factor (VEGF). It is used in treatment of diabetic microvascular comp
Uses
Ruboxistaurin is a protein kinase C (PKC) β inhibitor, exhibits significant anti-angiogenic activity that reduces the response of vascular endothelial cells to stimulation by vascular endothelial growth factor (VEGF). Ruboxistaurin is used in treatment of diabetic microvascular complications.