RUBOXISTAURIN HYDROCHLORIDE

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RUBOXISTAURIN HYDROCHLORIDE

Product Name: RUBOXISTAURIN HYDROCHLORIDE
CAS No.: 169939-93-9
Chemical Name: RUBOXISTAURIN HYDROCHLORIDE
Synonyms: LY333531 HCl;Ruboxistaurin HCl;Ruboxistaurin(LY333531HCl);Ruboxistaurin Hydrochloride;Ruboxistaurin HCl(LY333531 );Ruboxistaurin hydrochloride (LY333531);LY 333531 hydrochloride - Ruboxistaurin;LY333531 Hydrochloride(Ruboxistaurin HCl);Ruboxistaurin|||LY333531 HCl|||LY 333531 hydrochloride;(7S)-7-((Dimethylamino)methyl)-22,25-dihydro-11H,21H,31H-6-oxa-1,3(3,1)-diindola-2(3,4)-pyrrolacyclononaphane-22,25-dione hydrochloride
CBNumber: CB9206452
Molecular Formula: C28H29ClN4O3
Formula Weight: 505.02
MOL File: 169939-93-9.mol

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RUBOXISTAURIN HYDROCHLORIDE Property

alpha: D25 -28.7° (c = 1.0 in ethanol)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO: soluble10mg/mL, clear
form: powder
color: orange-red

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0693
Product name: LY-333531 hydrochloride
Purity: ≥98% (HPLC)
Packaging: 1mg
Price: $152
Updated: 2024/03/01

Cayman Chemical

Product number: 13964
Product name: LY333531 (hydrochloride)
Purity: ≥98%
Packaging: 1mg
Price: $106
Updated: 2024/03/01

Cayman Chemical

Product number: 13964
Product name: LY333531 (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $311
Updated: 2024/03/01

TRC

Product number: R701525
Product name: RuboxistaurinHydrochloride
Packaging: 0.5mg
Price: $185
Updated: 2021/12/16

Axon Medchem

Product number: Axon2362
Product name: LY333531hydrochloride-Ruboxistaurin
Purity: 99%
Packaging: 5mg
Price: $214.5
Updated: 2021/12/16

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RUBOXISTAURIN HYDROCHLORIDE Chemical Properties,Usage,Production

Description

LY333531 is an inhibitor of PKCβ (IC₅₀s = 4.7 and 5.9 nM for PKCβ1 and PKCβ2, respectively). It is selective for PKCβ1 and PKCβ2 over PKCα, -γ, -δ, -ε, -ζ, and -η (IC₅₀s = 360, 300, 250, >100,000, and 52 nM, respectively). LY333531 also inhibits glycogen synthase kinase 3β (GSK3β; IC₅₀ = 39.4 nM). It inhibits neutrophil extracellular trap (NET) formation induced by phorbol 12-myristate 13-acetate (PMA; ) in primary human neutrophils when used at a concentration of 1 μM. LY333531 increases the mechanical nociceptive threshold in a rat model of diabetic hyperalgesia induced by streptozotocin (STZ; ).

Uses

A protein kinase C (PKC) β inhibitor, exhibits significant anti-angiogenic activity that reduces the response of vascular endothelial cells to stimulation by vascular endothelial growth factor (VEGF). It is used in treatment of diabetic microvascular comp

Uses

Ruboxistaurin is a protein kinase C (PKC) β inhibitor, exhibits significant anti-angiogenic activity that reduces the response of vascular endothelial cells to stimulation by vascular endothelial growth factor (VEGF). Ruboxistaurin is used in treatment of diabetic microvascular complications.

RUBOXISTAURIN HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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169939-93-9, RUBOXISTAURIN HYDROCHLORIDERelated Search:

Trimethylamine hydrochloride Betaine hydrochloride L-Lysine hydrochloride Dimethylamine hydrochloride RUBOXISTAURIN HYDROCHLORIDE RUBOXISTAURIN 3-Isopropenyl-1-methyl-1H-pyrrole 3,4-Di-1H-indol-3-yl-1H-pyrrole-2,5-dione

Ruboxistaurin Hydrochloride

(9S)-9-[(DiMethylaMino)Methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-DiMethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione Hydrochloride

(S)-9-[(Dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione monohydrochloride

Ruboxistaurin HCl

Ruboxistaurin(LY333531HCl)

LY 333531 hydrochloride - Ruboxistaurin

Ruboxistaurin hydrochloride (LY333531)

Ruboxistaurin HCl(LY333531 )

LY333531 HCl

(7S)-7-((Dimethylamino)methyl)-22,25-dihydro-11H,21H,31H-6-oxa-1,3(3,1)-diindola-2(3,4)-pyrrolacyclononaphane-22,25-dione hydrochloride

LY333531 Hydrochloride(Ruboxistaurin HCl)

Ruboxistaurin|||LY333531 HCl|||LY 333531 hydrochloride

169939-93-9

C28H28N4O3HCl

C28H29N4O3Cl

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