4-Chloro-6-iodoquinazoline

Product Name: 4-Chloro-6-iodoquinazoline
CAS No.: 98556-31-1
Chemical Name: 4-Chloro-6-iodoquinazoline
Synonyms: oro-6-iodoquinazoL;4-Chloro-6-iodiquinazoline;6-Iodo-4-chloroquinazoline;4-CHLORO-6-IODOQUINAZOLINE;4-chloro-6-iodo-qulinazoline;Quinazoline, 4-chloro-6-iodo-;4-Chloro-6-iodoquinazoline 95+%;4-Chloro-6-iodoquinazoline USP/EP/BP;6 - iodine - 4 - chloroquine thiazole Moiety;4-Chloro-6-iodoquinazoline 6-Iodo-4-chloroquinazoline
CBNumber: CB9208456
Molecular Formula: C8H4ClIN2
Formula Weight: 290.49
MOL File: 98556-31-1.mol

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4-Chloro-6-iodoquinazoline Property

Melting point:: 175.0 to 179.0 °C
Boiling point:: 363.2±22.0 °C(Predicted)
Density: 2.017±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: Chloroform (Slightly), Methanol (Slightly, Heated)
pka: 0.15±0.30(Predicted)
form: Solid
color: Light Brown to Dark Grey
Stability:: Hygroscopic
InChI: InChI=1S/C8H4ClIN2/c9-8-6-3-5(10)1-2-7(6)11-4-12-8/h1-4H
InChIKey: BDAIUOPDSRAOKI-UHFFFAOYSA-N
SMILES: N1=C2C(C=C(I)C=C2)=C(Cl)N=C1
CAS DataBase Reference: 98556-31-1(CAS DataBase Reference)

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Safety

HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical

Product number: C2775
Product name: 4-Chloro-6-iodoquinazoline
Purity: >98.0%(GC)
Packaging: 1g
Price: $90
Updated: 2025/07/31

TRC

Product number: C367295
Product name: 4-Chloro-6-iodoquinazoline
Packaging: 1g
Price: $185
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC32925
Product name: 4-Chloro-6-iodoquinazoline
Packaging: 1g
Price: $195.4
Updated: 2021/12/16

Chem-Impex

Product number: 44892
Product name: 4-Chloro-6-iodoquinazoline,≥98%(GC)
Purity: ≥98%(GC)
Packaging: 25G
Price: $97.88
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC32925
Product name: 4-Chloro-6-iodoquinazoline
Packaging: 500mg
Price: $120
Updated: 2021/12/16

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4-Chloro-6-iodoquinazoline Chemical Properties,Usage,Production

Chemical Properties

Dark Grey Solid

Uses

4-Chloro-6-iodoquinazoline is an intermediate in the synthesis of Lapatinib (L175800).

Synthesis

16064-08-7

98556-31-1

Step B: Synthesis of 4-chloro-6-iodoquinazoline. Anhydrous dimethylformamide (DMF, 3.20 ml) was added to a stirred solution of 1,2-dichloroethane (DCE, 10 ml) under nitrogen protection and subsequently cooled in an ice water bath. A solution of oxalyl chloride (5.2 ml, 60 mmol) in DCE (25 ml) was slowly added dropwise. Formation of white precipitate was observed during dropwise addition. After completion of dropwise addition, the ice water bath was removed and the reaction mixture was continued to be stirred at room temperature for 5 minutes. Under nitrogen atmosphere, 6-iodo-4(H)-quinazolinone (5.0 g, 18 mmol) was added in batches, followed immediately by heating the mixture to reflux. After maintaining the reflux reaction for 4.5 h, it was cooled to room temperature. The reaction mixture was poured into an excess of ice-water mixture (about 300 ml) and extracted with dichloromethane (DCM, about 500 ml). The aqueous layer was further extracted with DCM (2 x 50 ml). All organic extracts were combined, dried with anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to give 5.2 g (99% yield) of 4-chloro-6-iodoquinazoline as a brown solid.

References

[1] Patent: US2005/101617, 2005, A1. Location in patent: Page/Page column 6
[2] Patent: WO2011/2523, 2011, A1. Location in patent: Page/Page column 43
[3] Patent: KR2017/15848, 2017, A. Location in patent: Paragraph 0067; 0071; 0072
[4] Patent: CN106317026, 2017, A. Location in patent: Paragraph 0075; 0076; 0077; 0078
[5] Patent: CN103772411, 2016, B. Location in patent: Paragraph 0017; 0027; 0028

4-Chloro-6-iodoquinazoline Preparation Products And Raw materials

Raw materials

Potassium hydroxide Phosphorus oxitrichloride Sodium bisulfite Phosphorus pentachloride Iodine Acetic acid Anthranilic acid Formamide

Preparation Products

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4-Chloro-6-iodoquinazoline Suppliers

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View Lastest Price from 4-Chloro-6-iodoquinazoline manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 6-Iodo-4-Chloroquinazoline 98556-31-1
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 ton
Release date: 2024-12-16

Henan Aochuang Chemical Co.,Ltd.

Product: 4-Chloro-6-iodoquinazoline 98556-31-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-10-09

Career Henan Chemica Co

Product: 4-Chloro-6-iodoquinazoline 988556-31-1
Price: US $1.00/g
Min. Order: 1g
Purity: 85.0-99.8%
Supply Ability: 20ton
Release date: 2020-10-28

98556-31-1, 4-Chloro-6-iodoquinazolineRelated Search:

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4-CHLORO-6-IODOQUINAZOLINE

6-Iodo-4-chloroquinazoline

Quinazoline, 4-chloro-6-iodo-

4-chloro-6-iodo-qulinazoline

6 - iodine - 4 - chloroquine thiazole Moiety

4-Chloro-6-iodoquinazoline 6-Iodo-4-chloroquinazoline

4-Chloro-6-iodoquinazoline 95+%

oro-6-iodoquinazoL

4-Chloro-6-iodoquinazoline USP/EP/BP

4-Chloro-6-iodiquinazoline

98556-31-1

988556-31-1

C8H4ClIN2

Lapatinib

pharmacetical