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TENOVIN-1

Product Name
TENOVIN-1
CAS No.
380315-80-0
Chemical Name
TENOVIN-1
Synonyms
CS-571;TENOVIN-1;Tenovin-1, >=98%;TENOVIN-1 USP/EP/BP;TENOVIN-1;TENOVIN 1;N-[(4-acetaMidophenyl)carbaMothioyl]-4-tert-butylbenzaMide;N-[[[4-(Acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)benzamide;Benzamide, N-[[[4-(acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)-;N-[[[4-(Acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)benzamide Tenovin 1;Tenovin 1 N-[[[4-(Acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)benzamide
CBNumber
CB92446962
Molecular Formula
C20H23N3O2S
Formula Weight
369.48
MOL File
380315-80-0.mol
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TENOVIN-1 Property

Melting point:
>180°C (Subl.)
Density 
1.238±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Soluble in DMSO (10 mg/ml with warming)
pka
9.09±0.70(Predicted)
form 
solid
color 
White
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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Safety

RIDADR 
3077
HS Code 
29242990
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
13085
Product name
Tenovin-1
Purity
≥98%
Packaging
5mg
Price
$33
Updated
2024/03/01
Cayman Chemical
Product number
13085
Product name
Tenovin-1
Purity
≥98%
Packaging
10mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
13085
Product name
Tenovin-1
Purity
≥98%
Packaging
50mg
Price
$254
Updated
2024/03/01
Cayman Chemical
Product number
13085
Product name
Tenovin-1
Purity
≥98%
Packaging
100mg
Price
$443
Updated
2024/03/01
Tocris
Product number
3365
Product name
Tenovin-1
Purity
≥99%(HPLC)
Packaging
10
Price
$64
Updated
2021/12/16
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TENOVIN-1 Chemical Properties,Usage,Production

Description

Tenovin-1 is a small molecule activator of p53 transcriptional activity. At 10 μM, it elevates p53 expression in MCF-7 cells within two hours of treatment and longer-term exposure significantly decreases the growth of BL2 Burkitt’s lymphoma and ARN8 melanoma cells. Functioning upstream of p53, tenovin-1 acts by inhibiting the deacetylase activity of purified human SIRT1 and SIRT2, members of NAD+-dependent class III histone deacetylases that belong to the sirtuin family. While tenovin-1 demonstrates low genotoxicity, the compound has poor water solubility, which limits its uses in vivo.

Uses

Tenovin 1 is a sirtuin inhibitor.

Definition

ChEBI: N-[(4-acetamidoanilino)-sulfanylidenemethyl]-4-tert-butylbenzamide is a member of thioureas.

Biological Activity

p53 activator that protects against MDM2-mediated p53 degradation. Elevates levels of p53 and p21 CIP/WAF1 and induces expression from an endogenous p53-dependent promoter. Exhibits potent antiproliferative activity in vitro .

References

Lain et al. (2008), Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator; Cancer Cell, 13 454 Sonnemann et al. (2014), p53-dependent and p53-independent anticancer effects of different histone deacetylase inhibitors; Br. J. Cancer 110 656 Nihal et al. (2014), SIRT1 is upregulated in cutaneous T-cell lymphoma, and its inhibition induces growth arrest and apoptosis; Cell Cycle 13 632 Wilking et al. (2014), SIRT1 deacetylase is overexpressed in human melanoma and its small molecule inhibition imparts anti-proliferative response via p53 activation; Arch. Biochem. Biophys. 563 94 Marx et al. (2018), The sirtuin 1/2 inhibitor tenovin-1 induces a nonlinear apoptosis-inducing factor-dependent cell death in a p53 null Ewing’s sarcoma cell line; New Drugs 36 396 Bang et al. (2019), Tenovin-1 Induces Senescence and Decreases Wound-Healing Activity in Cultured Rat Primary Astrocytes; Biomol. Ther. (Seoul) 27 283

TENOVIN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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TENOVIN-1 Suppliers

China 92 India 2 United Kingdom 1 United States 17 Global 112
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77
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View Lastest Price from TENOVIN-1 manufacturers

Career Henan Chemical Co
Product
TENOVIN-1 380315-80-0
Price
US $5.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1ton
Release date
2019-09-03

380315-80-0, TENOVIN-1Related Search:

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  • CS-571
  • TENOVIN-1
  • N-[[[4-(Acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)benzamide
  • N-[(4-acetaMidophenyl)carbaMothioyl]-4-tert-butylbenzaMide
  • Benzamide, N-[[[4-(acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)-
  • N-[[[4-(Acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)benzamide Tenovin 1
  • Tenovin 1 N-[[[4-(Acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)benzamide
  • Tenovin-1, >=98%
  • TENOVIN-1;TENOVIN 1
  • TENOVIN-1 USP/EP/BP
  • 380315-80-0
  • Inhibitor
  • Inhibitors