3-Amino-N-(4-methoxybenzyl)-4,6-dimethylthieno[2,3-b]pyridinecarboxamide

Product Name: 3-Amino-N-(4-methoxybenzyl)-4,6-dimethylthieno[2,3-b]pyridinecarboxamide
CAS No.: 409351-28-6
Chemical Name: 3-Amino-N-(4-methoxybenzyl)-4,6-dimethylthieno[2,3-b]pyridinecarboxamide
Synonyms: VU0152100;VU 152100;VU0152100, 10 mM in DMSO;VU152100;VU 0152100;VU-0152100;VU0152100, M4 positive allosteric modulator;3-Amino-N-(4-methoxybenzyl)-4,6-dimethylthieno[2,3-b]pyridinecarboxamide;3-Amino-N-(4-methoxybenzyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide;3-Amino-N-[(4-methoxyphenyl)methyl]-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide;Thieno[2,3-b]pyridine-2-carboxamide, 3-amino-N-[(4-methoxyphenyl)methyl]-4,6-dimethyl-;VU-152100,Inhibitor,Muscarinic acetylcholine receptor,inhibit,VU0152100,VU 152100,mAChR,VU-0152100,VU 0152100
CBNumber: CB92518759
Molecular Formula: C18H19N3O2S
Formula Weight: 341.43
MOL File: 409351-28-6.mol

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3-Amino-N-(4-methoxybenzyl)-4,6-dimethylthieno[2,3-b]pyridinecarboxamide Property

Density: 1.282
storage temp.: Store at RT
solubility: DMSO: >50mg/mL
form: powder
color: Light yellow to khaki

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Safety

Hazard Codes: T
Risk Statements: 25-36
Safety Statements: 26-45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: V5015
Product name: VU0152100
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $108
Updated: 2024/03/01

Sigma-Aldrich

Product number: V5015
Product name: VU0152100
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $414
Updated: 2023/06/20

Tocris

Product number: 3383
Product name: VU152100
Purity: ≥98%(HPLC)
Packaging: 10
Price: $185
Updated: 2021/12/16

Tocris

Product number: 3383
Product name: VU152100
Purity: ≥98%(HPLC)
Packaging: 50
Price: $778
Updated: 2021/12/16

Usbiological

Product number: 257071
Product name: VU 152100
Packaging: 10mg
Price: $438
Updated: 2021/12/16

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3-Amino-N-(4-methoxybenzyl)-4,6-dimethylthieno[2,3-b]pyridinecarboxamide Chemical Properties,Usage,Production

Uses

VU 152100 is a positive allosteric modulator of muscarinic choline receptor M4.

Biological Activity

vu0152100 is a selective and positive allosteric modulators of m4 receptor with the ec50 value of 380±93nm[1].vu0152100 has shown a potent positive allosteric modulators that increase the response of the m4 receptor to the endogenous agonist ach in in vitro study. in addition, vu0152100 has been reported to dese-dependently potentiate the response to the agonist (ach) with the ec50 value of 1.9±0.2μm, and increase the maximal response to ach to approximately 130%. furthermore, vu0152100 has been revealed to enhance receptor activation by increasing the affinity of m4 for acetylcholine. apart from these, vu0152100 has been found to induce a 20 to 25-fold leftward shift in the potency of ach to displace [3h]nms binding to m4 receptor with the ki value from 252±19.7nm to 12.2±0.49nm [1].

storage

Store at RT

References

[1] brady ae1, jones ck, bridges tm, kennedy jp, thompson ad, heiman ju, breininger ml, gentry pr, yin h, jadhav sb, shirey jk, conn pj, lindsley cw. centrally active allosteric potentiators of the m4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats. j pharmacol exp ther. 2008 dec;327(3):941-53.

3-Amino-N-(4-methoxybenzyl)-4,6-dimethylthieno[2,3-b]pyridinecarboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Amino-N-(4-methoxybenzyl)-4,6-dimethylthieno[2,3-b]pyridinecarboxamide Suppliers

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409351-28-6, 3-Amino-N-(4-methoxybenzyl)-4,6-dimethylthieno[2,3-b]pyridinecarboxamideRelated Search:

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VU0152100

3-Amino-N-(4-methoxybenzyl)-4,6-dimethylthieno[2,3-b]pyridinecarboxamide

VU 152100

3-Amino-N-[(4-methoxyphenyl)methyl]-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide

VU152100;VU 0152100;VU-0152100

Thieno[2,3-b]pyridine-2-carboxamide, 3-amino-N-[(4-methoxyphenyl)methyl]-4,6-dimethyl-

3-Amino-N-(4-methoxybenzyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide

VU-152100,Inhibitor,Muscarinic acetylcholine receptor,inhibit,VU0152100,VU 152100,mAChR,VU-0152100,VU 0152100

VU0152100, M4 positive allosteric modulator

VU0152100, 10 mM in DMSO

409351-28-6