ChemicalBook > CAS DataBase List > Ro 3306

Ro 3306

Product Name: Ro 3306
CAS No.: 872573-93-8
Chemical Name: Ro 3306
Synonyms: CS-770;Ro 3306;RO3306;RO 3306;Ro 3306 USP/EP/BP;Ro-3306, 10 mM in DMSO;Ro 3306, cyclin-dependent kinase (Cdk1) inhibitor;5-(6-Quinolinylmethylene)-2-[(2-thienylmethyl)amino]-4(5H)-thiazolone;(5Z)-5-Quinolin-6-ylmethylene-2-[(thiophen-2-ylmethyl)-amino]-thiazol-4-one;(Z)-5-(quinolin-6-ylmethylene)-2-(thiophen-2-ylmethylamino)thiazol-4(5H)-one;4(5H)-Thiazolone, 5-(6-quinolinylmethylene)-2-[(2-thienylmethyl)amino]-, (5Z)-
CBNumber: CB92535693
Molecular Formula: C18H13N3OS2
Formula Weight: 351.45
MOL File: 872573-93-8.mol

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Ro 3306 Property

Boiling point:: 569.1±60.0 °C(Predicted)
Density: 1.41
storage temp.: 2-8°C
solubility: DMSO: soluble5mg/mL, clear
pka: 3.99±0.10(Predicted)
form: powder
color: white to light brown
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0569
Product name: RO-3306
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $138.7
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML0569
Product name: RO-3306
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $602
Updated: 2025/07/31

TCI Chemical

Product number: R0201
Product name: RO-3306
Packaging: 10MG
Price: $127
Updated: 2023/01/07

TCI Chemical

Product number: R0201
Product name: RO-3306
Packaging: 50MG
Price: $378
Updated: 2023/01/07

Cayman Chemical

Product number: 15149
Product name: Ro 3306
Purity: ≥95%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

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Ro 3306 Chemical Properties,Usage,Production

Description

RO-3306 (872573-93-8) is a selective inhibitor of CDK1 (IC50?= 35 nM versus CDK2 IC50?= 340nM).1,2?It induces G2/M phase cell cycle arrest and apoptosis. Inhibition of CDK1 with RO-3306 has been shown to have synergistic effects with PARP inhibitors in treating various breast cancers.3,4?It has also been demonstrated to overcome apoptotic resistance in BRAFV600E?human colorectal cancer cells.5

Uses

RO-3306 is an ATP-competitive and selective CDK1 inhibitor used against a diverse panel of human kinases. Used in the treatment of malignant tumors in conjunction with PARP inhibitors.

Uses

RO-3306 has been used:

To study the significance of CA4-mediated cytotoxicity in mitotic arrest
In cell cycle synchronization to conduct a study on proteomics
As a CDK1 inhibitor, to prevent early mitotic entry

Biochem/physiol Actions

RO-3306 is a selective ATP-competitive inhibitor of CDK1. It inhibites CDK1 cyclin B1 activity with Ki of 35 nM, nearly 10-fold selectivity relative to CDK2/cyclin E and over 50-fold relative to CDK4/cyclin D. RO-3306 has been used to cause cell cycle arrest at the G2/M boundary.

IC 50

CDK1: 20 nM (Ki); CDK1/cyclinB1: 35 nM (Ki); CDK1/cyclin A: 110 nM (Ki); CDK2/cyclinE: 340 nM (Ki); PKCδ: 318 nM (Ki); SGK: 497 nM (Ki); ERK: 1980 nM (Ki)

storage

Store at +4°C

References

[1] LYUBOMIR T VASSILEV. Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2006: 10660-10665. DOI:10.1073/pnas.0600447103
[2] LILIANA KRASINSKA Daniel F Emilie Cot. Selective chemical inhibition as a tool to study Cdk1 and Cdk2 functions in the cell cycle.[J]. Cell Cycle, 2008: 1702-1708. DOI:10.4161/cc.7.12.6101
[3] AISLING PIERCE. Comparative antiproliferative effects of iniparib and olaparib on a panel of triple-negative and non-triple-negative breast cancer cell lines.[J]. Cancer Biology & Therapy, 2013, 14 6: 537-545. DOI:10.4161/cbt.24349
[4] QING XIA. The CDK1 inhibitor RO3306 improves the response of BRCA-proﬁcient breast cancer cells to PARP inhibition.[J]. International journal of oncology, 2014, 44 3: 735-744. DOI:10.3892/ijo.2013.2240
[5] PENG ZHANG. Targeting CDK1 and MEK/ERK Overcomes Apoptotic Resistance in BRAF-Mutant Human Colorectal Cancer.[J]. Molecular Cancer Research, 2018, 16 3: 378-389. DOI:10.1158/1541-7786.mcr-17-0404

Ro 3306 Preparation Products And Raw materials

Raw materials

Preparation Products

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Ro 3306 Suppliers

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View Lastest Price from Ro 3306 manufacturers

Career Henan Chemical Co

Product: 4(5H)-Thiazolone, 5-(6-quinolinylmethylene)-2-[(2-thienylmethyl)amino]-, (5Z)- 872573-93-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2019-12-23

872573-93-8, Ro 3306Related Search:

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Ro 3306

2-[[(Thiophen-2-yl)methyl]amino]-5-[1-(quinolin-6-yl)meth-(Z)-ylidene]thiazol-4-one

(Z)-5-(quinolin-6-ylmethylene)-2-(thiophen-2-ylmethylamino)thiazol-4(5H)-one

(5Z)-5-Quinolin-6-ylmethylene-2-[(thiophen-2-ylmethyl)-amino]-thiazol-4-one

5-(6-Quinolinylmethylene)-2-[(2-thienylmethyl)amino]-4(5H)-thiazolone

RO3306;RO 3306

4(5H)-Thiazolone, 5-(6-quinolinylmethylene)-2-[(2-thienylmethyl)amino]-, (5Z)-

(5Z)-5-(quinolin-6-ylmethylidene)-2-(thiophen-2-ylmethylamino)-1,3-thiazol-4-one

CS-770

Ro 3306 USP/EP/BP

Ro 3306, cyclin-dependent kinase (Cdk1) inhibitor

Ro-3306, 10 mM in DMSO

872573-93-8

Inhibitors