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Ro 3306

Product Name
Ro 3306
CAS No.
872573-93-8
Chemical Name
Ro 3306
Synonyms
CS-770;Ro 3306;RO3306;RO 3306;Ro 3306 USP/EP/BP;5-(6-Quinolinylmethylene)-2-[(2-thienylmethyl)amino]-4(5H)-thiazolone;(5Z)-5-Quinolin-6-ylmethylene-2-[(thiophen-2-ylmethyl)-amino]-thiazol-4-one;(Z)-5-(quinolin-6-ylmethylene)-2-(thiophen-2-ylmethylamino)thiazol-4(5H)-one;4(5H)-Thiazolone, 5-(6-quinolinylmethylene)-2-[(2-thienylmethyl)amino]-, (5Z)-;(5Z)-5-(quinolin-6-ylmethylidene)-2-(thiophen-2-ylmethylamino)-1,3-thiazol-4-one;2-[[(Thiophen-2-yl)methyl]amino]-5-[1-(quinolin-6-yl)meth-(Z)-ylidene]thiazol-4-one
CBNumber
CB92535693
Molecular Formula
C18H13N3OS2
Formula Weight
351.45
MOL File
872573-93-8.mol
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Ro 3306 Property

Boiling point:
569.1±60.0 °C(Predicted)
Density 
1.41
storage temp. 
2-8°C
solubility 
DMSO: soluble5mg/mL, clear
pka
3.99±0.10(Predicted)
form 
powder
color 
white to light brown
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0569
Product name
RO-3306
Purity
≥98% (HPLC)
Packaging
5mg
Price
$142
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0569
Product name
RO-3306
Purity
≥98% (HPLC)
Packaging
25mg
Price
$557
Updated
2024/03/01
TCI Chemical
Product number
R0201
Product name
RO-3306
Packaging
10MG
Price
$127
Updated
2023/01/07
TCI Chemical
Product number
R0201
Product name
RO-3306
Packaging
50MG
Price
$378
Updated
2023/01/07
Cayman Chemical
Product number
15149
Product name
Ro 3306
Purity
≥95%
Packaging
1mg
Price
$37
Updated
2024/03/01
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Ro 3306 Chemical Properties,Usage,Production

Description

RO-3306 (872573-93-8) is a selective inhibitor of CDK1 (IC50?= 35 nM versus CDK2 IC50?= 340nM).1,2?It induces G2/M phase cell cycle arrest and apoptosis. Inhibition of CDK1 with RO-3306 has been shown to have synergistic effects with PARP inhibitors in treating various breast cancers.3,4?It has also been demonstrated to overcome apoptotic resistance in BRAFV600E?human colorectal cancer cells.5

Uses

RO-3306 is an ATP-competitive and selective CDK1 inhibitor used against a diverse panel of human kinases. Used in the treatment of malignant tumors in conjunction with PARP inhibitors.

Uses

RO-3306 has been used:

  • To study the significance of CA4-mediated cytotoxicity in mitotic arrest
  • In cell cycle synchronization to conduct a study on proteomics
  • As a CDK1 inhibitor, to prevent early mitotic entry

Biochem/physiol Actions

RO-3306 is a selective ATP-competitive inhibitor of CDK1. It inhibites CDK1 cyclin B1 activity with Ki of 35 nM, nearly 10-fold selectivity relative to CDK2/cyclin E and over 50-fold relative to CDK4/cyclin D. RO-3306 has been used to cause cell cycle arrest at the G2/M boundary.

storage

Store at +4°C

References

1) Vassilev?et al.?(2006),?Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1; Proc. Nat. Acad. Sci. USA?103?10660 2) Krasinska?et al.?(2008),?Selective chemical inhibition as a tool to study Cdk1 and Cdk2 functions in the cell cycle; Cell Cycle?7?1702 3) Pierce?et al.?(2013),?Comparative antiproliferative effects of iniparib and olaparib on a panel of triple-negative and non-triple-negative breast cancer cell lines; Cancer Biol. Ther.?14?537 4) Xia?et al.?(2014),?The CDK1 inhibitor RO3306 improves the response of BRCA-proficient breast cancer cells to PARP inhibition;?Int. J. Oncol.?44?735 5) Zhang?et al.?(2018),?Targeting CDK1 and MEK/ERK Overcomes Apoptotic Resistance in BRAF-Mutant Human Colorectal Cancer; Mol. Cancer Res.?16?378

Ro 3306 Preparation Products And Raw materials

Raw materials

Preparation Products

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Ro 3306 Suppliers

China 90 India 2 Japan 1 United Kingdom 1 United States 17 Global 111
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
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View Lastest Price from Ro 3306 manufacturers

Career Henan Chemical Co
Product
4(5H)-Thiazolone, 5-(6-quinolinylmethylene)-2-[(2-thienylmethyl)amino]-, (5Z)- 872573-93-8
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2019-12-23

872573-93-8, Ro 3306Related Search:

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  • Ro 3306
  • 2-[[(Thiophen-2-yl)methyl]amino]-5-[1-(quinolin-6-yl)meth-(Z)-ylidene]thiazol-4-one
  • (Z)-5-(quinolin-6-ylmethylene)-2-(thiophen-2-ylmethylamino)thiazol-4(5H)-one
  • (5Z)-5-Quinolin-6-ylmethylene-2-[(thiophen-2-ylmethyl)-amino]-thiazol-4-one
  • 5-(6-Quinolinylmethylene)-2-[(2-thienylmethyl)amino]-4(5H)-thiazolone
  • RO3306;RO 3306
  • 4(5H)-Thiazolone, 5-(6-quinolinylmethylene)-2-[(2-thienylmethyl)amino]-, (5Z)-
  • (5Z)-5-(quinolin-6-ylmethylidene)-2-(thiophen-2-ylmethylamino)-1,3-thiazol-4-one
  • CS-770
  • Ro 3306 USP/EP/BP
  • 872573-93-8
  • Inhibitors