2,3,4-Trimethoxybenzaldehyde

Product Name: 2,3,4-Trimethoxybenzaldehyde
CAS No.: 2103-57-3
Chemical Name: 2,3,4-Trimethoxybenzaldehyde
Synonyms: TriMetazidine EP IMpurity-C;Benzaldehyde, 2,3,4-trimethoxy-;2,3,4-TMB;AKOS BBS-00003174;2,3,4-TrimethoxybenzaL;Trimetazidine Impurity C;4-TriMethoxybenzaldehyde;trimetazidine impurity1139;2,3,4-Trimetoxybenzaldehyde;Trimetazidine intermediate
CBNumber: CB9260504
Molecular Formula: C10H12O4
Formula Weight: 196.2
MOL File: 2103-57-3.mol

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2,3,4-Trimethoxybenzaldehyde Property

Melting point:: 38-40 °C(lit.)
Boiling point:: 168-170 °C12 mm Hg(lit.)
Density: 1.2166 (rough estimate)
refractive index: n20/D 1.5547(lit.)
Flash point:: >230 °F
storage temp.: Inert atmosphere,2-8°C
solubility: methanol: 0.1 g/mL, clear
form: Crystals or Crystalline Powder
color: White to light yellow
Sensitive: Air Sensitive
BRN: 981091
InChI: InChI=1S/C10H12O4/c1-12-8-5-4-7(6-11)9(13-2)10(8)14-3/h4-6H,1-3H3
InChIKey: UCTUXUGXIFRVGX-UHFFFAOYSA-N
SMILES: C(=O)C1=CC=C(OC)C(OC)=C1OC
CAS DataBase Reference: 2103-57-3(CAS DataBase Reference)
NIST Chemistry Reference: Benzaldehyde, 2,3,4-trimethoxy-(2103-57-3)
EPA Substance Registry System: Benzaldehyde, 2,3,4-trimethoxy- (2103-57-3)

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Safety

Hazard Codes: Xi,C
Risk Statements: 36/37/38-34
Safety Statements: 22-24/25-45-36/37/39-27-26
WGK Germany: 3
Hazard Note: Irritant
TSCA: Yes
HS Code: 29124900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 152099
Product name: 2,3,4-Trimethoxybenzaldehyde
Purity: 99%
Packaging: 10g
Price: $34.3
Updated: 2025/07/31

Sigma-Aldrich

Product number: 152099
Product name: 2,3,4-Trimethoxybenzaldehyde
Purity: 99%
Packaging: 50g
Price: $111
Updated: 2025/07/31

TCI Chemical

Product number: T1101
Product name: 2,3,4-Trimethoxybenzaldehyde
Purity: >98.0%(GC)
Packaging: 25g
Price: $63
Updated: 2025/07/31

TRC

Product number: T795685
Product name: 2,3,4-Trimethoxybenzaldehyde
Packaging: 25g
Price: $85
Updated: 2021/12/16

TRC

Product number: T795685
Product name: 2,3,4-Trimethoxybenzaldehyde
Packaging: 100g
Price: $215
Updated: 2021/12/16

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2,3,4-Trimethoxybenzaldehyde Chemical Properties,Usage,Production

Description

2,3,4-Trimethoxybenzaldehyde is a white crystalline powder, and the chemical formula is C 10H 12O 4; the molecular weight is 196.2; the fusing point is 38-40 degrees, and is a kind of important medicine intermediate; it is mainly used in new type drug Ca2+ Synthesizing of channel blocker. The alternative cerebral arteries that are used for this medicine reduce the headache incidence, mainly for the preparation of the intermediate of trimetazidine.

Synthesis

A coking gallic acid is utilized as a raw material, and dimethyl sulfate is utilized as an alkylate reagent; under the condition of the existence of sodium hydroxide, methylation is performed through an O-alkylation reaction to obtain an intermediate 1, 2, 3-trimethoxybenzene. After that, the 1,2, 3-trimethoxybenzene and a Vilsmeier-Haack reagent are subjected to a formylation reaction to get the 2,3,4-Trimethoxybenzaldehyde.

Chemical Properties

white to light yellow crystals or cryst. powder

Uses

2,3,4-Trimethoxybenzaldehyde is a trimethoxylated aromatic aldehyde. 2,3,4-Trimethoxybenzaldehyde is an Impurity of the anti-anginal drug Trimetazidine (T795610).

Uses

2,3,4-Trimethoxybenzaldehyde was used to study the effects of 2,3,4-trimethoxybenzaldehyde on tubulin-dependent GTP hydrolysis.

References

[1] Organic and Biomolecular Chemistry, 2014, vol. 12, # 22, p. 3721 - 3734
[2] Molecules, 2015, vol. 20, # 5, p. 9229 - 9241
[3] Justus Liebigs Annalen der Chemie, 1972, vol. 763, p. 109 - 120

2,3,4-Trimethoxybenzaldehyde Preparation Products And Raw materials

Raw materials

Gallic acid

Preparation Products

Trimethoprim

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2,3,4-Trimethoxybenzaldehyde Suppliers

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View Lastest Price from 2,3,4-Trimethoxybenzaldehyde manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 2,3,4-Trimethoxybenzaldehyde 2103-57-3
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 ton
Release date: 2024-11-27

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2,3,4-Trimethoxybenzaldehyde 2103-57-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-28

Jiurui Biology Chemistry Co.,Ltd.

Product: 2,3,4-Trimethoxy Benzaldehyde 2103-57-3
Price: US $1.00/KG
Min. Order: 100KG
Purity: 99%MIN.
Supply Ability: 100MT/Year
Release date: 2022-08-17

2103-57-3, 2,3,4-TrimethoxybenzaldehydeRelated Search:

3-(Trifluoromethyl)benzaldehyde 3-Methoxybenzaldehyde p-Anisaldehyde 4-(Trifluoromethoxy)aniline Trimethyl phosphite Mesitaldehyde 3-(Trifluoromethoxy)bromobenzene o-Anisaldehyde (Trifluoromethoxy)benzene 2,3,4-Trihydroxybenzaldehyde 2,3,4-TRIMETHOXYPHENYLACETIC ACID TriMethopriM IMpurity C 3-Iodobenzyl bromide 3-Anilino-2-(3,4,5-triMethoxybenzyl)acrylonitrile, (Mixture of cis/trans isoMers) Trimethoprim Related Compound B (25 mg) (2,4-diaminopyrimidin-5-yl)(3,4,5-trimethoxyphenyl)methanone) (AS) 1,4-Bis(2,3,4-triMethoxybenzyl)piperazine 4-[(2,3,4-TriMethoxyphenyl)Methyl]-1-piperazinecarboxylic Acid Ethyl Ester 1-(3,4,5-TRIMETHOXY-BENZYL)-PIPERAZINE

2,3,4-trimethoxy-benzaldehyd

2,3,4-TRIMETHOXYBENZALDEHYDE FOR SYNTHES

TriMetazidine EP IMpurity-C

Trimetazidine Impurity C

2,3,4-TriMethoxybenzaldehyde, 97+%

2,3,4-TrimethoxybenzaL

2,3,4-Trimedhoxy Benzaldehyde

Trimetazidine Impurity 3（Trimetazidine EP Impurity C)

2,3,4-Trimethoxybenzaidehyde

2,3,4 TRIMETHOXYBENZYLALDEHYDE

2,3,4-TRIMETHOXYBENZALDEHYDE

2,3,4-TMB

2,3,4-Trimethoxybenzaldehyde, 99+%

Benzaldehyde, 2,3,4-trimethoxy-

2,3,4-trimethoxybenzaldehyde (intermediate of trimetazidine.)

2,3,4-Trimetoxybenzaldehyde

4.2,3,4-trimethoxybenzaldehyde

2,3,4-TRIMETHOXYBENZALDEHYDE, 98+%

4-TriMethoxybenzaldehyde

2,3,4-TriMethoxybenzaldehyde, 99% 10GR

AKOS BBS-00003174

2,3,4-Trimethoxybenzaldehyde ISO 9001：2015 REACH

trimetazidine impurity1139

2,3,4-Trimethoxybenzaldehyde (Trimetazidine Hydrochloride Impurity)

Trimetazidine intermediate

Trimetazidine Dihydrochloride EP Impurity C

Trimetazidine Dihydrochloride Impurity C

2103-57-3

2103-57-31

Organic Building Blocks

ALDEHYDE

Aldehydes

Building Blocks

C10 to C21

Carbonyl Compounds

Aromatics, Impurities, Intermediates

BUILDING BLOCKS

Benzaldehyde

API intermediates

(intermediate of trimetazidine.)

Aldehydes

C10 to C21

Carbonyl Compounds

Aromatic Aldehydes & Derivatives (substituted)

bc0001

2103-57-3