CATHEPSIN D
- Product Name
- CATHEPSIN D
- CAS No.
- 9025-26-7
- Chemical Name
- CATHEPSIN D
- Synonyms
- CATHEPSIN D;EC 3.4.23.5;EC 3.4.22.5;Cathepsins D;CATHEPSIN D, HUMAN;CATHEPSIN D, BOVINE;CATHEPSIN D, HUMAN LIVER;Native Human Cathepsin D;CATHEPSIN D, HUMAN SPLEEN;Native Bovine Cathepsin D
- CBNumber
- CB9265367
- Molecular Formula
- NULL
- Formula Weight
- 0
- MOL File
- Mol file
CATHEPSIN D Property
- storage temp.
- -20°C
- form
- lyophilized powder
- color
- white
- Water Solubility
- Reconstitute in water at 1µg/µl
N-Bromosuccinimide Price
- Product number
- C3138
- Product name
- Cathepsin D from bovine spleen
- Purity
- lyophilized powder, ≥2.0?units/mg protein
- Packaging
- 5UNITS
- Price
- $289
- Updated
- 2024/03/01
- Product number
- C8696
- Product name
- Cathepsin D from human liver
- Purity
- lyophilized powder, ≥250?units/mg protein (E1%/280)
- Packaging
- 25μg
- Price
- $373
- Updated
- 2024/03/01
- Product number
- C3138
- Product name
- Cathepsin D from bovine spleen
- Purity
- lyophilized powder, ≥2.0?units/mg protein
- Packaging
- 10UNITS
- Price
- $493
- Updated
- 2024/03/01
- Product number
- C3138
- Product name
- Cathepsin D from bovine spleen
- Purity
- lyophilized powder, ≥2.0?units/mg protein
- Packaging
- 20UNITS
- Price
- $875
- Updated
- 2024/03/01
- Product number
- C3138
- Product name
- Cathepsin D from bovine spleen
- Purity
- lyophilized powder, ≥2.0?units/mg protein
- Packaging
- 40UNITS
- Price
- $1540
- Updated
- 2023/01/07
CATHEPSIN D Chemical Properties,Usage,Production
Uses
Cathepsin D, human liver is useful for inhibitor screening, kinetic studies, and cleavage of substrates in vitro or in tissue culture. It contains the mannose-6-phosphate lysosomal localization signal that targets the enzyme to the lysosomal compartment where it functions in the normal degradation of proteins. It is a useful prognostic indicator for breast cancer.
Uses
Cathepsin D from human liver has been used:
- in β-secretase activity assay
- for enzymatic degradation of amyloid β 1-42
- in microinjection of human foreskin fibroblasts
General Description
Cathepsin D is an aspartic protease, which is located in lysosomes. It is involved in protein catabolism and maintains hormone and antigen processing. Cathepsin D is implicated in neoplasia and neurodegenerative changes. It regulates lysosomal proteolysis and endogenous fibrinolysis.
Biochem/physiol Actions
Cathepsin D is an endosomal-lysosomal aspartic protease implicated in breast cancer metastasis and Alzheimer′s disease. Lysosomal release of cathepsin D has been found to precede cytochrome c release and loss of membrane potential in apoptotic human foreskin fibroblasts. Cathepsin D levels in PC12 cells increase 12 to 24 hours after apoptosis is induced.
Purification Methods
Cathepsin D is purified on a CM column after (NH4)2SO4 fractionation and dialysis, then starch-gel electrophoresis and by ultracentrifugal analysis. Finally chromatograph on a DEAE column [Press et al. Biochem J 74 501 1960].
CATHEPSIN D Preparation Products And Raw materials
Raw materials
Preparation Products
CATHEPSIN D Suppliers
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