ChemicalBook > CAS DataBase List > 4-Cyanopiperidine

4-Cyanopiperidine

Product Name
4-Cyanopiperidine
CAS No.
4395-98-6
Chemical Name
4-Cyanopiperidine
Synonyms
PIPERIDINE-4-CARBONITRILE;4-cyanopiperdine;4-CYANOPIPERIDINE;sonipecotonitrile;Isonipecotonitrile;CHEMBRDG-BB 4009819;Piperidine-4-carboni;5-AMINOPHTHALONITRILE;4-CYANOPIPERIDINE >98%;Piperidin-4-carbonitrile
CBNumber
CB9265756
Molecular Formula
C6H10N2
Formula Weight
110.16
MOL File
4395-98-6.mol
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4-Cyanopiperidine Property

Melting point:
0°C
Boiling point:
0°C
Density 
0.987 g/mL at 25 °C
refractive index 
1.4755
Flash point:
0°C
storage temp. 
2-8°C
solubility 
Soluble in chloroform.
form 
Liquid
pka
9.26±0.10(Predicted)
color 
Colorless to pale yellow
InChI
InChI=1S/C6H10N2/c7-5-6-1-3-8-4-2-6/h6,8H,1-4H2
InChIKey
FSDNTQSJGHSJBG-UHFFFAOYSA-N
SMILES
N1CCC(C#N)CC1
CAS DataBase Reference
4395-98-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
20/21/22-36/37/38-41-22
Safety Statements 
26-36/37/39-36-39
RIDADR 
3276
WGK Germany 
3
Hazard Note 
Harmful
HazardClass 
6.1
PackingGroup 
III
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
749583
Product name
Piperidine-4-carbonitrile
Purity
97%
Packaging
5g
Price
$96.7
Updated
2023/01/07
Sigma-Aldrich
Product number
749583
Product name
Piperidine-4-carbonitrile
Purity
97%
Packaging
25g
Price
$203
Updated
2023/01/07
TRC
Product number
C987540
Product name
4-Cyanopiperidine
Packaging
2.5g
Price
$115
Updated
2021/12/16
Oakwood
Product number
024547
Product name
4-Cyanopiperidine
Purity
98%
Packaging
1g
Price
$14
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
JK314896
Product name
4-Cyanopiperidine
Purity
98%
Packaging
1g
Price
$17
Updated
2021/12/16
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4-Cyanopiperidine Chemical Properties,Usage,Production

Chemical Properties

Yellowish-Orangish Oil

Uses

4-Cyanopiperidine is used as an intermediate for the preparation of pharmaceutical substances like antidepressants and anti-inflammatory. It is used as a precursor for the synthesis of piperidine derivatives.

Synthesis

91419-52-2

4395-98-6

The general procedure for the synthesis of 4-cyanopiperidine from N-Boc-4-cyanopiperidine is as follows: Step A: Preparation of 4-cyanopiperidine hydrochloride (mt17-1) N-Boc-4-cyanopiperidine (4.00 g, 19.0 mmol) was dissolved in 20 mL of 4M HCl/EtOAc solution and stirred at room temperature for 30 min. After completion of the reaction, the mixture was concentrated under vacuum to give 2.10 g of 4-cyanopiperidine hydrochloride (mt17-1) as a white solid in 100% yield. 1H-NMR (DMSO-d6) δ: 9.32 (br, 1H), 3.18-3.08 (m, 3H), 2.97-2.92 (m, 2H), 2.08-2.04 (m, 2H), 1.95-1.85 (m, 2H).

References

[1] Patent: WO2014/178, 2014, A1. Location in patent: Page/Page column 102
[2] Patent: WO2014/4416, 2014, A1. Location in patent: Page/Page column 102
[3] Patent: US2014/5103, 2014, A1. Location in patent: Paragraph 0459; 0460
[4] Patent: US2015/197531, 2015, A1. Location in patent: Paragraph 0460
[5] Chemical and Pharmaceutical Bulletin, 2001, vol. 49, # 7, p. 822 - 829

4-Cyanopiperidine Preparation Products And Raw materials

Raw materials

1,1'-Carbonyldiimidazole Di-tert-butyl dicarbonate Potassium carbonate Chloroform 1,4-Dioxane Tetrahydrofuran Trifluoroacetic anhydride Ethyl acetate Isonipecotic acid Thionyl chloride Ammonia

Preparation Products

NORMEPERIDINE
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4-Cyanopiperidine Suppliers

Belgium 1 Canada 4 CHINA 146 France 1 Germany 11 India 19 Ireland 1 Switzerland 1 The Netherlands 1 United Kingdom 16 United States 51 Global 252
Shanghai Meilv Pharmatech Co. Ltd
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Alfa Aesar
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Energy Chemical
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View Lastest Price from 4-Cyanopiperidine manufacturers

Career Henan Chemical Co
Product
4-Cyanopiperidine 4395-98-6
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
as request
Release date
2018-12-21

4395-98-6, 4-CyanopiperidineRelated Search:

ETHYL 2-CYANOACRYLATE DROPERIDOL Haloperidol Methylene dithiocyanate Diphenoxylate 4-CYANOQUINUCLIDINE 1-BENZYL-4-CYANO-4-HYDROXYPIPERIDINE 4-ANILINO-1-BENZYL-4-CYANOPIPERIDINE 4-CYANO-4-PHENYLPIPERIDINE HYDROCHLORIDE 1-Benzyl-4-cyano-4-phenylpiperidine hydrochloride 1-CBZ-3-CYANOPIPERIDINE,BENZYL-3-CYANOPIPERIDINE-1-CARBOXYLATE (S) 2-CYANOPIPERIDINE,2-CYANOPIPERIDINE 1-Cyanopiperidine,N-CYANOPIPERIDINE TERT-BUTYL 4-CYANOPIPERIDINE-1-CARBOXYLATE,Boc-4-cyanopiperidine,1-BOC-4-CYANOPIPERIDINE,4-CYANOPIPERIDINE, N-BOC PROTECTED (R)-1-N-BOC-3-CYANO-PIPERIDINE 4-CYANOPIPERIDINE HCL 1-Boc-2-cyanopiperidine 1-N-BOC-3-CYANOPIPERIDINE,TERT-BUTYL-3-CYANOPIPERIDINE-1-CARBOXYLATE,1-Boc-3-cyanopiperidine

  • PIPERIDINE-4-CARBONITRILE
  • 4-CYANOPIPERIDINE
  • CHEMBRDG-BB 4009819
  • 4-CYANOPIPERIDINE >98%
  • 4-CYANO PIPERIDINE PIPERIDINE-4-CARBONITRILE
  • 5-AMINOPHTHALONITRILE
  • piperidine-4-carbonitrile(SALTDATA: HCl)
  • 4-cyanopiperdine
  • Piperidin-4-carbonitrile
  • 4-Piperidinecarbonitrile hydrochloride
  • Piperidine-4-carbonitrile hydrochloride 98%
  • sonipecotonitrile
  • 4-Cyanopiperidine, Isonipecotonitrile
  • Isonipecotonitrile
  • 4-Cyano-piperidine hydroc...
  • Piperidine-4-carboni
  • 4-Cyanopiperidine(HCl salt form)
  • 4-Piperidinecarbonitrile (9CI, ACI)
  • Piperidine-4-carbonitrile - [C4799]
  • 4395-98-6
  • Amines and Anilines
  • Boron, Nitrile, Thio,& TM-Cpds
  • Aromatics
  • Piperidine