ChemicalBook > CAS DataBase List > tert-butyl 4-(4-aMino-5-isopropoxy-2-Methylphenyl)piperidine-1-carboxylate
tert-butyl 4-(4-aMino-5-isopropoxy-2-Methylphenyl)piperidine-1-carboxylate
- Product Name
- tert-butyl 4-(4-aMino-5-isopropoxy-2-Methylphenyl)piperidine-1-carboxylate
- CAS No.
- 1032903-63-1
- Chemical Name
- tert-butyl 4-(4-aMino-5-isopropoxy-2-Methylphenyl)piperidine-1-carboxylate
- Synonyms
- 4-(1-Boc-4-piperidyl)-2-isopropoxy-5-methylaniline;N-Boc-4-(4-amino-5-isopropoxy-2-methylphenyl)piperidine;tert-butyl 4-(4-aMino-5-isopropoxy-2-Methylphenyl)piperidine...;tert-butyl 4-(4-aMino-5-isopropoxy-2-Methylphenyl)piperidine-1-carboxylate;TERT-BUTYL 4-(4-AMINO-5-ISOPROPOXY-2-METHYLPHENYLI，I FE)PIPERIDINE-1-CARBOXYLATE;4-(4-AMino-5-isopropoxy-2-Methyl-phenyl)-piperidine-1-carboxylic acid tert-butyl ester;1-Piperidinecarboxylic acid, 4-[4-amino-2-methyl-5-(1-methylethoxy)phenyl]-, 1,1-dimethylethyl ester
- CBNumber
- CB92663798
- Molecular Formula
- C20H32N2O3
- Formula Weight
- 348.48
- MOL File
- 1032903-63-1.mol
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tert-butyl 4-(4-aMino-5-isopropoxy-2-Methylphenyl)piperidine-1-carboxylate Property
- Boiling point:
- 470.4±45.0 °C(Predicted)
- Density
- 1.072±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 6.16±0.16(Predicted)
- Appearance
- White to off-white Solid
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TRC
- Product number
- B811213
- Product name
- tert-Butyl4-(4-Amino-5-isopropoxy-2-methylphenyl)piperidine-1-carboxylate
- Packaging
- 50mg
- Price
- $220
- Updated
- 2021/12/16
AK Scientific
- Product number
- 4109AH
- Product name
- tert-Butyl4-(4-amino-5-isopropoxy-2-methylphenyl)piperidine-1-carboxylate
- Packaging
- 10g
- Price
- $571
- Updated
- 2021/12/16
Ambeed
- Product number
- A138834
- Product name
- tert-Butyl4-(4-amino-5-isopropoxy-2-methylphenyl)piperidine-1-carboxylate
- Purity
- 97%
- Packaging
- 250mg
- Price
- $25
- Updated
- 2021/12/16
Ambeed
- Product number
- A138834
- Product name
- tert-Butyl4-(4-amino-5-isopropoxy-2-methylphenyl)piperidine-1-carboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $61
- Updated
- 2021/12/16
Ambeed
- Product number
- A138834
- Product name
- tert-Butyl4-(4-amino-5-isopropoxy-2-methylphenyl)piperidine-1-carboxylate
- Purity
- 97%
- Packaging
- 5g
- Price
- $182
- Updated
- 2021/12/16
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tert-butyl 4-(4-aMino-5-isopropoxy-2-Methylphenyl)piperidine-1-carboxylate Chemical Properties,Usage,Production
Synthesis
1032903-52-8
1032903-63-1
Tert-butyl 4-(5-isopropyl-2-methyl-4-nitrophenyl)-3,6-dihydropyridine-1-carboxylate (22.6 g, 0.06 mol) was used as a raw material, which was added to methanol (226 mL) with carbon-loaded palladium hydroxide (20% w/w, 2.26 g). The reaction mixture was stirred at 30-40 °C for 5 h in hydrogen pressure (1 MPa). The completion of the reaction was monitored by TLC. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated. To the concentrate n-heptane was added and stirred at 0-10 °C for 2 h to crystallize. The crystals were collected by filtration and the filter cake was dried under vacuum at 40-50 °C to afford tert-butyl 4-(4-amino-5-isopropoxy-2-methylphenyl)piperidine-1-carboxylate as a white solid powder (19.9 g, yield: 95.0%).
References
[1] Patent: CN105461616, 2016, A. Location in patent: Paragraph 0031; 0032; 0033
[2] Patent: EP3287463, 2018, A1. Location in patent: Paragraph 0164; 0167
[3] Patent: KR2016/147358, 2016, A. Location in patent: Paragraph 0238-0240
[4] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 17, p. 3738 - 3743
[5] Patent: CN108276410, 2018, A. Location in patent: Paragraph 0129; 0130; 0131
tert-butyl 4-(4-aMino-5-isopropoxy-2-Methylphenyl)piperidine-1-carboxylate Preparation Products And Raw materials
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Preparation Products
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View Lastest Price from tert-butyl 4-(4-aMino-5-isopropoxy-2-Methylphenyl)piperidine-1-carboxylate manufacturers
Career Henan Chemical Co
- Product
- tert-butyl 4-(4-aMino-5-isopropoxy-2-Methylphenyl)piperidine-1-carboxylate 1032903-63-1
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-07-30
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