Prednisolone-21-acetate

ChemicalBook > CAS DataBase List > Prednisolone-21-acetate

Prednisolone-21-acetate

Product Name: Prednisolone-21-acetate
CAS No.: 52-21-1
Chemical Name: Prednisolone-21-acetate
Synonyms: PREDNISOLONE ACETATE;Sterane;PREDNISOLONE 21-ACETATE;Econopred;Ak-Tate;Prenema;Deltilen;Durapred;Nisolone;Omnipred
CBNumber: CB9274994
Molecular Formula: C23H30O6
Formula Weight: 402.49
MOL File: 52-21-1.mol

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Prednisolone-21-acetate Property

Melting point:: 240-244 °C
Boiling point:: 579.8±50.0 °C(Predicted)
alpha: D25 +116° (dioxane)
Density: 1.28±0.1 g/cm3(Predicted)
refractive index: 112 ° (C=1, Dioxane)
storage temp.: 2-8°C
solubility: Practically insoluble in water, slightly soluble in ethanol (96 per cent) and in methylene chloride.
pka: 12.41±0.70(Predicted)
color: White to Off-White
Water Solubility: 11.6mg/L(25 ºC)
Merck: 7721
BRN: 3111798
Stability:: Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference: 52-21-1(CAS DataBase Reference)
NIST Chemistry Reference: 1,4-Pregnadiene-3,20-dione, 11beta,17alpha,21-trihydroxy-, acetate(52-21-1)

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Safety

Hazard Codes: N
Risk Statements: 25-34-11
Safety Statements: 45-36/37/39-26-16
WGK Germany: 3
RTECS: TU4152500
HS Code: 29372900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P8650
Product name: Prednisolone 21-acetate
Purity: ≥97%
Packaging: 1g
Price: $65.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: BP1140
Product name: Prednisolone acetate
Purity: British Pharmacopoeia (BP) Reference Standard
Packaging: 100MG
Price: $265
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1556008
Product name: Prednisolone acetate
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $436
Updated: 2024/03/01

Sigma-Aldrich

Product number: Y0000582
Product name: Prednisolone acetate for peak identification
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0000582
Price: $220
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHR1630
Product name: Prednisolone acetate
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 1g
Price: $144
Updated: 2024/03/01

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Prednisolone-21-acetate Chemical Properties,Usage,Production

Chemical Properties

White or almost white, crystalline powder.

Originator

Sterane, Phipharmex ,US ,1955

Uses

Synthetic corticosteroid; metabolically interconvertible with prednisone.

Uses

glucocorticoid

Definition

ChEBI: Prednisolone acetate is a corticosteroid hormone.

Manufacturing Process

To a solution of 0.85 gram of 1,4-pregnadiene-11β,17α,21-triol-3,20-dione (prednisolone) in 5 ml of pyridine are added 3 ml of acetic anhydride. The reaction mixture is allowed to stand at room temperature overnight and is then diluted with ice water. The resulting precipitate is filtered from the mixture and recrystallized from acetone-hexane. There is recovered 0.45 gram of 1,4-pregnadiene-11β,17α,21-triol-3,20-dione 21-acetate, MP 235°239°C. On recrystallization, the MP rose to 237°-239°C.

brand name

Econopred (Alcon); Meticortelone (Schering); Omnipred (Alcon); Sterane (Pfizer).

Therapeutic Function

Glucocorticoid

Biological Activity

Prednisolone Acetate (Omnipred) is a synthetic corticosteroid that is a particularly potent immunosuppressant.

Clinical Use

For rheumatoid arthritis, rheumatic fever, lupus erythematosus, scleroderma, dermatomyositis, acute lymphoblastic leukemia, etc.

Purification Methods

Recrystallise prednisolone acetate from EtOH, Me2CO, Me2CO/hexane, and it has UV with max at 243nm in EtOH. [Joly et al. Bull Soc Chim Fr 366 1958; Herzog et al. J Am Chem Soc 77 4781 1955, Beilstein 8 IV 3468.]

Prednisolone-21-acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Prednisolone-21-acetate manufacturers

Hebei Kangcang new material Technology Co., LTD

Product: Prednisolone Acetate 52-21-1
Price: US $20.00-10.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 20
Release date: 2024-03-20

Hebei Kangcang new material Technology Co., LTD

Product: Prednisolone Acetate 52-21-1
Price: US $9.00-60.00/g
Min. Order: 10g
Purity: min99%
Supply Ability: 10 tons
Release date: 2024-03-22

Shaanxi TNJONE Pharmaceutical Co., Ltd

Product: Prednisolone Acetate 52-21-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20tons
Release date: 2024-04-23

52-21-1, Prednisolone-21-acetate Related Search:

Prednisone 21-acetate Ethylene glycol monoethyl ether acetate Ethyl acetate Isopropyl acetate 2-Butoxyethyl acetate Vinyl acetate POLY(VINYL ACETATE) Tocopheryl acetate Prednisolone D-alpha-Tocopheryl acetate Trenbolone acetate Sodium acetate Glatiramer acetate 1-Methoxy-2-propyl acetate Sodium acetate trihydrate Methylprednisolone Acetic acid Retinyl acetate

PREDNISOLONE ACETATE

PREDNISOLONE 21-ACETATE

PRICORTIN

1,4-PREGNADIENE-11BETA,17ALPHA,21-TRIOL 3,20-DIONE 21-ACETATE

1,4-PREGNADIENE-3,20-DIONE-11BETA,17ALPHA,21-TRIOL 21-ACETATE

1,4-PREGNADIEN-11BETA,17ALPHA,21-TRIOL-3,20-DIONE 21-ACETATE

1,4-PREGNADIEN-11-BETA, 17,21-TRIOL-3,20-DIONE 21-ACETATE

1-DEHYDROCORTISOL 21-ACETATE

21-ACETOXY-1,4-PREGNADIENE-11BETA,17ALPHA-DIOL-3,20-DIONE

METACORTANDROLONE ACETATE

(11beta)-21-(Acetyloxy)-11,17-dihydroxypregna-1,4-diene-3,20-dione

11,17-Dihydroxy-3,20-dioxopregna-1,4-dien-21-yl acetate

11beta,17,21-Trihydroxypregna-1,4-diene-3,20-dione 21-acetate

21-(acetyloxy)-11,17-dihydroxy-4-diene-(11-beta)-pregna-20-dione

21-(acetyloxy)-11,17-dihydroxy-4-diene-(11beta)-pregna-20-dione

4-diene-3,20-dione,11-beta,17,21-trihydroxy-pregna-21-acetate

Ak-Tate

component of Blephamide liquifilm,

component of Blephamide sop,

component of Cetapred ointment,

component of Composone

component of Isopto Cetapred

component of Metimyd

component of Mydapred,

component of Neo-delta-Cortef

component of Neo-delta-cortef,

component of Poly-pred,

component of Pred-g liquifilm,

component of Pred-g sop,

component of Vasocidin ointment

Cormalone

Cortipred

Delcort-E

Deltilen

Durapred

Econopred

Hostacortin H

Meticortelone acetate

meticorteloneacetate

Meticotelone acetate

Nisolone

Pred Forte

Pred Forte TM

Pred Mild

Predalone 50

Prediacortine

Predicort

Prednelan-N

Prednidoren

Predonine injection

predonineinjection

Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-, 21-acetate

Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-11,17-dihydroxy-, (11beta)-

Prenema

Sterane

Sterane IM and IA

Supercortyl

Prednisolone acetate micron