Prednisolone-21-acetate
- Product Name
- Prednisolone-21-acetate
- CAS No.
- 52-21-1
- Chemical Name
- Prednisolone-21-acetate
- Synonyms
- PREDNISOLONE ACETATE;Sterane;PREDNISOLONE 21-ACETATE;Econopred;Ak-Tate;Prenema;Deltilen;Durapred;Nisolone;Omnipred
- CBNumber
- CB9274994
- Molecular Formula
- C23H30O6
- Formula Weight
- 402.49
- MOL File
- 52-21-1.mol
Prednisolone-21-acetate Property
- Melting point:
- 240-244 °C
- Boiling point:
- 579.8±50.0 °C(Predicted)
- alpha
- D25 +116° (dioxane)
- Density
- 1.28±0.1 g/cm3(Predicted)
- refractive index
- 112 ° (C=1, Dioxane)
- storage temp.
- 2-8°C
- solubility
- Practically insoluble in water, slightly soluble in ethanol (96 per cent) and in methylene chloride.
- form
- Solid
- pka
- 12.41±0.70(Predicted)
- color
- White to Off-White
- Water Solubility
- 11.6mg/L(25 ºC)
- Merck
- 7721
- BRN
- 3111798
- Stability:
- Stable. Incompatible with strong oxidizing agents.
- CAS DataBase Reference
- 52-21-1(CAS DataBase Reference)
- NIST Chemistry Reference
- 1,4-Pregnadiene-3,20-dione, 11beta,17alpha,21-trihydroxy-, acetate(52-21-1)
Safety
- Hazard Codes
- N
- Risk Statements
- 25-34-11
- Safety Statements
- 45-36/37/39-26-16
- WGK Germany
- 3
- RTECS
- TU4152500
- HS Code
- 29372900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- P8650
- Product name
- Prednisolone 21-acetate
- Purity
- ≥97%
- Packaging
- 1g
- Price
- $65.2
- Updated
- 2024/03/01
- Product number
- BP1140
- Product name
- Prednisolone acetate
- Purity
- British Pharmacopoeia (BP) Reference Standard
- Packaging
- 100MG
- Price
- $265
- Updated
- 2024/03/01
- Product number
- 1556008
- Product name
- Prednisolone acetate
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 200mg
- Price
- $436
- Updated
- 2024/03/01
- Product number
- Y0000582
- Product name
- Prednisolone acetate for peak identification
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- y0000582
- Price
- $220
- Updated
- 2024/03/01
- Product number
- PHR1630
- Product name
- Prednisolone acetate
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 1g
- Price
- $144
- Updated
- 2024/03/01
Prednisolone-21-acetate Chemical Properties,Usage,Production
Chemical Properties
White or almost white, crystalline powder.
Originator
Sterane, Phipharmex ,US ,1955
Uses
Synthetic corticosteroid; metabolically interconvertible with prednisone.
Uses
glucocorticoid
Definition
ChEBI: Prednisolone acetate is a corticosteroid hormone.
Manufacturing Process
To a solution of 0.85 gram of 1,4-pregnadiene-11β,17α,21-triol-3,20-dione (prednisolone) in 5 ml of pyridine are added 3 ml of acetic anhydride. The reaction mixture is allowed to stand at room temperature overnight and is then diluted with ice water. The resulting precipitate is filtered from the mixture and recrystallized from acetone-hexane. There is recovered 0.45 gram of 1,4-pregnadiene-11β,17α,21-triol-3,20-dione 21-acetate, MP 235°239°C. On recrystallization, the MP rose to 237°-239°C.
brand name
Econopred (Alcon); Meticortelone (Schering); Omnipred (Alcon); Sterane (Pfizer).
Therapeutic Function
Glucocorticoid
Biological Activity
Prednisolone Acetate (Omnipred) is a synthetic corticosteroid that is a particularly potent immunosuppressant.
Clinical Use
For rheumatoid arthritis, rheumatic fever, lupus erythematosus, scleroderma, dermatomyositis, acute lymphoblastic leukemia, etc.
Purification Methods
Recrystallise prednisolone acetate from EtOH, Me2CO, Me2CO/hexane, and it has UV with max at 243nm in EtOH. [Joly et al. Bull Soc Chim Fr 366 1958; Herzog et al. J Am Chem Soc 77 4781 1955, Beilstein 8 IV 3468.]
Prednisolone-21-acetate Preparation Products And Raw materials
Raw materials
Preparation Products
Prednisolone-21-acetate Suppliers
- Tel
- --
- Fax
- --
- info@farmabios.com
- Country
- Italy
- ProdList
- 55
- Advantage
- 58
View Lastest Price from Prednisolone-21-acetate manufacturers
- Product
- Prednisolone-21-acetate 52-21-1
- Price
- US $885.00/Kg/Bag
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1T
- Release date
- 2021-06-04
- Product
- Prednisolone-21-acetate 52-21-1
- Price
- US $100.00-75.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000
- Release date
- 2024-08-21
- Product
- Prednisolone-21-acetate 52-21-1
- Price
- US $40.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10 tons
- Release date
- 2023-09-12