ChemicalBook > CAS DataBase List > Prednisolone-21-acetate

Prednisolone-21-acetate

Product Name
Prednisolone-21-acetate
CAS No.
52-21-1
Chemical Name
Prednisolone-21-acetate
Synonyms
PREDNISOLONE ACETATE;Sterane;PREDNISOLONE 21-ACETATE;Econopred;Ak-Tate;Prenema;Deltilen;Durapred;Nisolone;Omnipred
CBNumber
CB9274994
Molecular Formula
C23H30O6
Formula Weight
402.49
MOL File
52-21-1.mol
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Prednisolone-21-acetate Property

Melting point:
240-244 °C
Boiling point:
579.8±50.0 °C(Predicted)
alpha 
D25 +116° (dioxane)
Density 
1.28±0.1 g/cm3(Predicted)
refractive index 
112 ° (C=1, Dioxane)
storage temp. 
2-8°C
solubility 
Practically insoluble in water, slightly soluble in ethanol (96 per cent) and in methylene chloride.
form 
Solid
pka
12.41±0.70(Predicted)
color 
White to Off-White
Water Solubility 
11.6mg/L(25 ºC)
Merck 
7721
BRN 
3111798
Stability:
Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference
52-21-1(CAS DataBase Reference)
NIST Chemistry Reference
1,4-Pregnadiene-3,20-dione, 11beta,17alpha,21-trihydroxy-, acetate(52-21-1)
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Safety

Hazard Codes 
N
Risk Statements 
25-34-11
Safety Statements 
45-36/37/39-26-16
WGK Germany 
3
RTECS 
TU4152500
HS Code 
29372900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P8650
Product name
Prednisolone 21-acetate
Purity
≥97%
Packaging
1g
Price
$65.2
Updated
2024/03/01
Sigma-Aldrich
Product number
BP1140
Product name
Prednisolone acetate
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
100MG
Price
$265
Updated
2024/03/01
Sigma-Aldrich
Product number
1556008
Product name
Prednisolone acetate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$436
Updated
2024/03/01
Sigma-Aldrich
Product number
Y0000582
Product name
Prednisolone acetate for peak identification
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0000582
Price
$220
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR1630
Product name
Prednisolone acetate
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
1g
Price
$144
Updated
2024/03/01
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Prednisolone-21-acetate Chemical Properties,Usage,Production

Chemical Properties

White or almost white, crystalline powder.

Originator

Sterane, Phipharmex ,US ,1955

Uses

Synthetic corticosteroid; metabolically interconvertible with prednisone.

Uses

glucocorticoid

Definition

ChEBI: Prednisolone acetate is a corticosteroid hormone.

Manufacturing Process

To a solution of 0.85 gram of 1,4-pregnadiene-11β,17α,21-triol-3,20-dione (prednisolone) in 5 ml of pyridine are added 3 ml of acetic anhydride. The reaction mixture is allowed to stand at room temperature overnight and is then diluted with ice water. The resulting precipitate is filtered from the mixture and recrystallized from acetone-hexane. There is recovered 0.45 gram of 1,4-pregnadiene-11β,17α,21-triol-3,20-dione 21-acetate, MP 235°239°C. On recrystallization, the MP rose to 237°-239°C.

brand name

Econopred (Alcon); Meticortelone (Schering); Omnipred (Alcon); Sterane (Pfizer).

Therapeutic Function

Glucocorticoid

Biological Activity

Prednisolone Acetate (Omnipred) is a synthetic corticosteroid that is a particularly potent immunosuppressant.

Clinical Use

For rheumatoid arthritis, rheumatic fever, lupus erythematosus, scleroderma, dermatomyositis, acute lymphoblastic leukemia, etc.

Purification Methods

Recrystallise prednisolone acetate from EtOH, Me2CO, Me2CO/hexane, and it has UV with max at 243nm in EtOH. [Joly et al. Bull Soc Chim Fr 366 1958; Herzog et al. J Am Chem Soc 77 4781 1955, Beilstein 8 IV 3468.]

Prednisolone-21-acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Prednisolone-21-acetate manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
Prednisolone-21-acetate 52-21-1
Price
US $100.00-75.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-08-21
Baoji Guokang Bio-Technology Co., Ltd.
Product
Prednisolone-21-acetate 52-21-1
Price
US $885.00/Kg/Bag
Min. Order
1KG
Purity
99%
Supply Ability
1T
Release date
2021-06-04
Hebei Yanxi Chemical Co., Ltd.
Product
Prednisolone-21-acetate 52-21-1
Price
US $40.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10 tons
Release date
2023-09-12

52-21-1, Prednisolone-21-acetate Related Search:

Prednisone 21-acetate Ethylene glycol monoethyl ether acetate Ethyl acetate Isopropyl acetate 2-Butoxyethyl acetate Vinyl acetate POLY(VINYL ACETATE) Tocopheryl acetate Prednisolone D-alpha-Tocopheryl acetate Trenbolone acetate Sodium acetate Glatiramer acetate 1-Methoxy-2-propyl acetate Sodium acetate trihydrate Acetic acid Methylprednisolone Retinyl acetate

  • PREDNISOLONE ACETATE
  • PREDNISOLONE 21-ACETATE
  • PRICORTIN
  • 1,4-PREGNADIENE-11BETA,17ALPHA,21-TRIOL 3,20-DIONE 21-ACETATE
  • 1,4-PREGNADIENE-3,20-DIONE-11BETA,17ALPHA,21-TRIOL 21-ACETATE
  • 1,4-PREGNADIEN-11BETA,17ALPHA,21-TRIOL-3,20-DIONE 21-ACETATE
  • 1,4-PREGNADIEN-11-BETA, 17,21-TRIOL-3,20-DIONE 21-ACETATE
  • 1-DEHYDROCORTISOL 21-ACETATE
  • 21-ACETOXY-1,4-PREGNADIENE-11BETA,17ALPHA-DIOL-3,20-DIONE
  • METACORTANDROLONE ACETATE
  • (11beta)-21-(Acetyloxy)-11,17-dihydroxypregna-1,4-diene-3,20-dione
  • 11,17-Dihydroxy-3,20-dioxopregna-1,4-dien-21-yl acetate
  • 11beta,17,21-Trihydroxypregna-1,4-diene-3,20-dione 21-acetate
  • 21-(acetyloxy)-11,17-dihydroxy-4-diene-(11-beta)-pregna-20-dione
  • 21-(acetyloxy)-11,17-dihydroxy-4-diene-(11beta)-pregna-20-dione
  • 4-diene-3,20-dione,11-beta,17,21-trihydroxy-pregna-21-acetate
  • Ak-Tate
  • component of Blephamide liquifilm,
  • component of Blephamide sop,
  • component of Cetapred ointment,
  • component of Composone
  • component of Isopto Cetapred
  • component of Metimyd
  • component of Mydapred,
  • component of Neo-delta-Cortef
  • component of Neo-delta-cortef,
  • component of Poly-pred,
  • component of Pred-g liquifilm,
  • component of Pred-g sop,
  • component of Vasocidin ointment
  • Cormalone
  • Cortipred
  • Delcort-E
  • Deltilen
  • Durapred
  • Econopred
  • Hostacortin H
  • Meticortelone acetate
  • meticorteloneacetate
  • Meticotelone acetate
  • Nisolone
  • Pred Forte
  • Pred Forte TM
  • Pred Mild
  • Predalone 50
  • Prediacortine
  • Predicort
  • Prednelan-N
  • Prednidoren
  • Predonine injection
  • predonineinjection
  • Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-, 21-acetate
  • Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-11,17-dihydroxy-, (11beta)-
  • Prenema
  • Sterane
  • Sterane IM and IA
  • Supercortyl
  • Prednisolone acetate micron