CID-49830258

Product Name: CID-49830258
CAS No.: 1346527-98-7
Chemical Name: CID-49830258
Synonyms: ML240;CS-2775;ML240, >98%;CID-49830258;ML240 >=98% (HPLC);Cdc48,inhibit,VCP,Inhibitor,ML240,ML 240,ML-240,p97;2-(2-amino-1H-benzo[d]imidazol-1-yl)-N-benzyl-8-methoxyquinazolin-4-amine;2-(2-Amino-1H-benzimidazol-1-yl)-8-methoxy-N-(phenylmethyl)-4-quinazolinamine;2-(2-Amino-1H-benzimidazole-1-yl)-8-methoxy-N-(phenylmethyl)-4-quinazolinamine;4-Quinazolinamine, 2-(2-amino-1H-benzimidazol-1-yl)-8-methoxy-N-(phenylmethyl)-
CBNumber: CB92751093
Molecular Formula: C23H20N6O
Formula Weight: 396.44
MOL File: 1346527-98-7.mol

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CID-49830258 Property

Boiling point:: 696.6±65.0 °C(Predicted)
Density: 1.35±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble5mg/mL, clear (warmed)
form: powder
pka: 4.53±0.10(Predicted)
color: white to yellow to light brown

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1071
Product name: ML240
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $81
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1071
Product name: ML240
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $535
Updated: 2024/03/01

Cayman Chemical

Product number: 17373
Product name: ML-240
Purity: ≥95%
Packaging: 1mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 17373
Product name: ML-240
Purity: ≥95%
Packaging: 5mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 17373
Product name: ML-240
Purity: ≥95%
Packaging: 10mg
Price: $168
Updated: 2024/03/01

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CID-49830258 Chemical Properties,Usage,Production

Uses

ML 240 is a p97 inhibitor in cancer and neurodegenerative diseases.

Uses

ML240 has been used as an inhibitor of D2 ATPase activity of valosin-containing protein.

Definition

ChEBI: ML240 is a member of the class of quinazolines that is quinazoline which is substituted at positions 2, 5 and 8 by 2-amino-1H-benzimidazol-1-yl, benzylnitrilo and methoxy groups, respectively. It is a ATP-competetive inhibitor of AAA ATPase p97, also known as valosin-containing protein (VCP). It has a role as an antineoplastic agent. It is a member of quinazolines, a member of benzimidazoles, a secondary amino compound, an aromatic amine, an aromatic ether and a primary amino compound.

Biochem/physiol Actions

ML240 is a selective, ATP-competetive inhibitor of AAA ATPase p97, also called valosine containing protein (VCP). The IC50 for p97 inhibition is 110 nM. ML240 rapidly induces activity of Caspases 3 and 7, leading to apoptosis. ML240 has potent antiproliferative activity towards NCI-60 cancer cell lines.

storage

Store at +4°C

CID-49830258 Preparation Products And Raw materials

Raw materials

Preparation Products

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CID-49830258 Suppliers

China 73 India 1 United Kingdom 1 United States 13 Global 88

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1346527-98-7, CID-49830258Related Search:

5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one ML-228 ML188 (Racemate) ML 18 ML-098 ML277 ML 204 ML329 ML364 VU0456810 ML188 ML418 [4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone ML213 N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine ML-327 PTP1B-IN-2 ML264

2-(2-Amino-1H-benzimidazole-1-yl)-8-methoxy-N-(phenylmethyl)-4-quinazolinamine

CS-2775

ML240, >98%

2-(2-Amino-1H-benzimidazol-1-yl)-8-methoxy-N-(phenylmethyl)-4-quinazolinamine

CID-49830258

ML240

2-(2-amino-1H-benzo[d]imidazol-1-yl)-N-benzyl-8-methoxyquinazolin-4-amine

4-Quinazolinamine, 2-(2-amino-1H-benzimidazol-1-yl)-8-methoxy-N-(phenylmethyl)-

ML240 >=98% (HPLC)

Cdc48,inhibit,VCP,Inhibitor,ML240,ML 240,ML-240,p97

1346527-98-7

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