4-Bromo-2-fluoroanisole

Product Name: 4-Bromo-2-fluoroanisole
CAS No.: 2357-52-0
Chemical Name: 4-Bromo-2-fluoroanisole
Synonyms: 4-Bromo-2-fluoro-1-methoxybenzene;4-Bromo-2-fluoroanis;4-Cyano-fluoro phenol;Fluoro-4-bromoanisole;2-Fluoro-4-Bromo Anisol;4-BROMO-2-FLUOROANISOLE;2-FLUORO-4-BROMOANISOLE;4-Bromo-2-fluoroanisole98%;4-Bromo-2-fluoroanisole>4-Bromo-2-fluoroanisole 98%
CBNumber: CB9282221
Molecular Formula: C7H6BrFO
Formula Weight: 205.02
MOL File: 2357-52-0.mol

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4-Bromo-2-fluoroanisole Property

Melting point:: 16 °C
Boiling point:: 84 °C/7 mmHg (lit.)
Density: 1.59 g/mL at 25 °C (lit.)
refractive index: n20/D 1.545(lit.)
Flash point:: 209 °F
storage temp.: Sealed in dry,Room Temperature
form: clear liquid
color: Colorless to Light yellow
Specific Gravity: 1.590
Water Solubility: insoluble
BRN: 3240714
InChI: InChI=1S/C7H6BrFO/c1-10-7-3-2-5(8)4-6(7)9/h2-4H,1H3
InChIKey: DWNXGZBXFDNKOR-UHFFFAOYSA-N
SMILES: C1(OC)=CC=C(Br)C=C1F
CAS DataBase Reference: 2357-52-0(CAS DataBase Reference)
NIST Chemistry Reference: 4-Bromo-2-fluoroanisole(2357-52-0)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-24/25
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29093090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 293474
Product name: 4-Bromo-2-fluoroanisole
Purity: 97%
Packaging: 5g
Price: $52.1
Updated: 2023/06/20

TCI Chemical

Product number: B1855
Product name: 4-Bromo-2-fluoroanisole
Purity: >98.0%(GC)
Packaging: 5g
Price: $33
Updated: 2025/07/31

TCI Chemical

Product number: B1855
Product name: 4-Bromo-2-fluoroanisole
Purity: >98.0%(GC)
Packaging: 25g
Price: $127
Updated: 2025/07/31

TRC

Product number: B691898
Product name: 4-Bromo-2-fluoroanisole
Packaging: 1g
Price: $55
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2607-B-04
Product name: 4-Bromo-2-fluoroanisole
Purity: 98%
Packaging: 100g
Price: $75
Updated: 2021/12/16

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4-Bromo-2-fluoroanisole Chemical Properties,Usage,Production

Chemical Properties

CLEAR VERY SLIGHTLY YELLOW LIQUID

Uses

4-Bromo-2-fluoroanisole has been used in the synthesis of:

1,4-bis[(3′-fluoro-4′-n alkoxyphenyl)ethynyl]benzenes with n=1-12
7-fluoro-6-methoxy-1-methyl-2-naphthaldehyde
5,7-difluoro-6-methoxy-1-methyl-2-naphthaldehyde
liquid crystals with terminal difluoromethoxy group and backbone of phenylbicyclohexane

General Description

The IR and FT-IR spectra of 4-bromo-2-fluoroanisole have been investigated.

Synthesis

321-28-8

2357-52-0

(a) Synthesis of 2-fluoro-4-bromoanisole: Add 128 g (1.016 mol) of 2-fluoroanisole and 250 ml of chloroform to the reaction vessel. Under stirring conditions at room temperature, 177 g (1.106 mol) of bromine was slowly added dropwise for not less than 3 hours. Upon completion of the reaction, the reaction mixture was poured into dilute aqueous sodium hydroxide solution to separate the chloroform layer. The chloroform layer was subsequently washed with saturated sodium chloride solution and dried with anhydrous sodium sulfate. The solvent was removed by distillation and the residue was distilled under reduced pressure to give 2-fluoro-4-bromoanisole. The yield was 192 g (yield: 92.3%) and the boiling point was 107°-116°C (25-31 mmHg).

References

[1] Journal of Organic Chemistry, 2018, vol. 83, # 2, p. 930 - 938
[2] Patent: US5098602, 1992, A
[3] Helvetica Chimica Acta, 1984, vol. 67, p. 1572 - 1579
[4] Patent: US5397504, 1995, A
[5] Patent: US4997942, 1991, A

4-Bromo-2-fluoroanisole Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Bromo-2-fluoroanisole Suppliers

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View Lastest Price from 4-Bromo-2-fluoroanisole manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 4-Bromo-2-fluoroanisole 2357-52-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-05-23

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-Bromo-2-fluoroanisole 2357-52-0
Price: US $30.00-10.00/KG
Min. Order: 50KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-11-05

Hebei Yanxi Chemical Co., Ltd.

Product: 4-Bromo-2-fluoroanisole 2357-52-0
Price: US $30.00-10.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10 tons
Release date: 2023-10-23

2357-52-0, 4-Bromo-2-fluoroanisole Related Search:

2-Bromofluorobenzene 4-Bromofluorobenzene 4-Fluoroanisole 2-Bromobenzonitrile 4-Fluorobenzaldehyde 4-Bromo-2-fluorobenzoic acid Florfenicol 3-Bromoanisole 4-Bromoanisole 2-Bromoanisole 3-Bromofluorobenzene 3-(Trifluoromethoxy)bromobenzene Anisole Transfluthrin Erucamide 1,3-Dibromobenzene 4-Bromo-2,6-dimethylaniline 4-Bromo-2-chlorobenzonitrile

4-Bromo-2-fluoro-1-methoxybenzene

Benzene, 4-bromo-2-fluoro-1-methoxy-

1-BROMO-3-FLUORO-4-METHOXYBENZENE

2-FLUORO-4-BROMOANISOLE

4-BROMO-2-FLUOROANISOLE

4-Bromo-2-fluoroanisole 98%

4-Bromo-2-fluoroanisole98%

4-Bromo-2-Fluoromethoxybenzene

4-Bromo-2-Fluoroanisole 2-Fluoro-4-Bromoanisole

2-Fluoro-4-Bromo Anisol

4-Bromo-2-fluoroanisole, 97+%

4-Bromo-2-fluoroanisole, 99+%

4-Cyano-fluoro phenol

4-Bromo-2-fluoroanis

4-Bromo-2-fluoro-1-methoxybenzene, 4-Bromo-2-fluorophenyl methyl ether

1-Methoxy-2-fluoro-4-bromobenzene

Fluoro-4-bromoanisole

4-Bromo-2-fluoroanisole&gt

4-Bromo-2-fluoroanisole ISO 9001：2015 REACH

2-Fluoro-4-bromobenzyl ether

2357-52-0

Organic Building Blocks

Ethers

Oxygen Compounds

ARYL HALIDE

Building Blocks

Aromatic Halides (substituted)

AnisoleSeries

Anisole

Miscellaneous

Anisoles, Alkyloxy Compounds & Phenylacetates

Bromine Compounds

Fluorine Compounds

Benzenes

Fluorobenzene Series

Other fluorin-contained compounds