ChemicalBook > CAS DataBase List > METHYL 4-AMINO-3-NITROBENZOATE

METHYL 4-AMINO-3-NITROBENZOATE

Product Name
METHYL 4-AMINO-3-NITROBENZOATE
CAS No.
3987-92-6
Chemical Name
METHYL 4-AMINO-3-NITROBENZOATE
Synonyms
4-AMINO-3-NITROMETHYLBENZOATE;METHYL 4-AMINO-3-NITROBENZOATE;Methyl 3-nitro-4-aminobenzoate;Methyl4-amino-3-nitrobenzoate,97%;METHYL 4-AMINO-3-NITROBENZENECARBOXYLATE;4-Amino-3-nitrobenzoic acid methyl ester;3-Nitro-4-aminobenzoic acid methyl ester;Benzoic acid, 4-amino-3-nitro-, methyl ester;methyl 4-amino-3-nitrobenzoatemethyl 4-amino-3-nitrobenzoate;2-Amino-5-(methoxycarbonyl)nitrobenzene, 4-(Methoxycarbonyl)-2-nitroaniline
CBNumber
CB9282610
Molecular Formula
C8H8N2O4
Formula Weight
196.16
MOL File
3987-92-6.mol
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METHYL 4-AMINO-3-NITROBENZOATE Property

Melting point:
204-206°C
Boiling point:
392.8±22.0 °C(Predicted)
Density 
1.386±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
-2.59±0.10(Predicted)
Appearance
Light yellow to yellow Solid
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Safety

Hazard Codes 
Xi
HazardClass 
IRRITANT
HS Code 
2922390090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
M328673
Product name
Methyl4-amino-3-nitrobenzoate
Packaging
100mg
Price
$45
Updated
2021/12/16
TRC
Product number
M328673
Product name
Methyl4-amino-3-nitrobenzoate
Packaging
500mg
Price
$65
Updated
2021/12/16
Matrix Scientific
Product number
042844
Product name
Methyl 4-amino-3-nitrobenzenecarboxylate
Purity
95+%
Packaging
1g
Price
$10
Updated
2021/12/16
Apolloscientific
Product number
OR15213
Product name
Methyl4-amino-3-nitrobenzoate
Packaging
5g
Price
$27
Updated
2021/12/16
SynQuest Laboratories
Product number
4658-1-Z3
Product name
Methyl 4-amino-3-nitrobenzoate
Packaging
5G
Price
$29
Updated
2021/12/16
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METHYL 4-AMINO-3-NITROBENZOATE Chemical Properties,Usage,Production

Chemical Properties

Methyl 4-amino-3-nitrobenzoate is a synthetic compound that has been found to have a variety of uses. It has been used to prepare intramolecular hydrogen bonds in anilines, and it can be used as an intermediate to synthesize amides and anilines. This molecule also forms resonance structures with the nitro group, which allows for increased stability. The proton magnetic resonance spectra of Methyl 4-amino-3-nitrobenzoate show that the molecule has a high degree of symmetry, which is due to the presence of intramolecular hydrogen bonding.

Synthesis

67-56-1

1588-83-6

3987-92-6

4-Amino-3-nitrobenzoic acid (50 g, 270 mmol, 1 eq.) was suspended in methanol (600 mL) at room temperature. Subsequently, sulfoxide chloride (20 mL, 270 mmol, 1 eq.) was slowly added dropwise to the above suspension. The reaction mixture was heated to reflux for 16 h. After completion of the reaction, it was cooled to room temperature. The resulting yellow solid, methyl 4-amino-3-nitrobenzoate (D1) (53 g, 100% yield), was collected by filtration, and the product could be used in subsequent reactions without further purification. Mass spectrometry analysis showed [M + H]+ = 197.3, retention time (RT) = 2.42 min.

References

[1] Patent: WO2004/94430, 2004, A1. Location in patent: Page 16
[2] Patent: WO2006/40148, 2006, A1. Location in patent: Page/Page column 19-20
[3] Patent: WO2015/57938, 2015, A1. Location in patent: Page/Page column 102
[4] Patent: CN106146416, 2016, A. Location in patent: Paragraph 0046; 0047; 0048; 0049; 0050
[5] European Journal of Medicinal Chemistry, 2018, vol. 143, p. 8 - 20

METHYL 4-AMINO-3-NITROBENZOATE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHYL 4-AMINO-3-NITROBENZOATE Suppliers

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View Lastest Price from METHYL 4-AMINO-3-NITROBENZOATE manufacturers

Asia Chem I and E (Jiangsu) Co Ltd
Product
Methyl 4-amino-3-nitrobenzoate 3987-92-6
Price
US $100.00/kg
Min. Order
1kg
Purity
98.0%min
Supply Ability
20tons/month
Release date
2024-12-30
Career Henan Chemical Co
Product
Methyl 4-amino-3-nitrobenzoate 3987-92-6
Price
US $7.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-25

3987-92-6, METHYL 4-AMINO-3-NITROBENZOATERelated Search:

Methyl 4-aMino-2,6-diMethylbenzoate Methyl 4-amino-3-bromobenzoate Methyl 2,6-dichloro-4-aminobenzoate Methyl 4-amino-3-(trifluoromethoxy)benzoate METHYL 4-AMINO-3-CHLOROBENZOATE METHYL 4-AMINO-2,3-DIFLUORO-5-NITROBENZOATE METHYL 4-AMINO-2,3-DIFLUOROBENZOATE METHYL 4-AMINO-3-CHLORO-5-METHYLBENZOATE Methyl-4-amino-3-fluorobenzoate Methyl 4-amino-2-chlorobenzoate Methyl 4-aMino-3,5-difluorobenzoate Methyl 4-amino-2-cyanobenzoate Methyl 4-amino-2-methoxybenzoate METHYL 4-AMINO-3,5-DICHLOROBENZOATE methyl 4-amino-2-chloro-5-iodobenzoate methyl 4-amino-2-bromo-3-fluorobenzoate Methyl-4-amino-3-bromo-5-methylbenzoate Methyl 4-amino-3-methoxybenzoate

  • 4-AMINO-3-NITROMETHYLBENZOATE
  • 3-Nitro-4-aminobenzoic acid methyl ester
  • 4-Amino-3-nitrobenzoic acid methyl ester
  • METHYL 4-AMINO-3-NITROBENZENECARBOXYLATE
  • METHYL 4-AMINO-3-NITROBENZOATE
  • methyl 4-amino-3-nitrobenzoatemethyl 4-amino-3-nitrobenzoate
  • Methyl 3-nitro-4-aminobenzoate
  • 2-Amino-5-(methoxycarbonyl)nitrobenzene, 4-(Methoxycarbonyl)-2-nitroaniline
  • Benzoic acid, 4-amino-3-nitro-, methyl ester
  • Methyl4-amino-3-nitrobenzoate,97%
  • 3987-92-6
  • Aromatic Esters