ChemicalBook > CAS DataBase List > DIETHYL BROMOMALONATE

DIETHYL BROMOMALONATE

Product Name
DIETHYL BROMOMALONATE
CAS No.
685-87-0
Chemical Name
DIETHYL BROMOMALONATE
Synonyms
Diethyl 2-bromomalonate;Diethylbrommalonat;RARECHEM AL BI 0815;ETHYL BROMOMALONATE;Diethyl bromalonate;DIETHYL BROMOMALONATE;Diethylebromomalonate;BROMO DIETHYL MALONATE;DiethylBromomalonate>Pregabalin Impurity 136
CBNumber
CB9294925
Molecular Formula
C7H11BrO4
Formula Weight
239.06
MOL File
685-87-0.mol
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DIETHYL BROMOMALONATE Property

Melting point:
-54°C
Boiling point:
233-235 °C (lit.)
Density 
1.402 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.451(lit.)
Flash point:
>230 °F
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Chloroform, Hexanes
form 
Liquid
pka
9.29±0.46(Predicted)
Specific Gravity
1.402
color 
Clear colorless to slightly yellow
Water Solubility 
Does not mix well with water.
Sensitive 
Lachrymatory
BRN 
509768
CAS DataBase Reference
685-87-0(CAS DataBase Reference)
EPA Substance Registry System
Propanedioic acid, 2-bromo-, 1,3-diethyl ester (685-87-0)
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Safety

Hazard Codes 
C
Risk Statements 
34
Safety Statements 
26-36/37/39-45
RIDADR 
UN 3265 8/PG 2
WGK Germany 
3
F 
19
Hazard Note 
Corrosive/Lachrymator
TSCA 
Yes
HazardClass 
8
PackingGroup 
III
HS Code 
29171900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D91209
Product name
Diethyl bromomalonate
Purity
92%
Packaging
25g
Price
$123
Updated
2025/07/31
Sigma-Aldrich
Product number
D91209
Product name
Diethyl bromomalonate
Purity
92%
Packaging
100g
Price
$322
Updated
2025/07/31
TCI Chemical
Product number
B1205
Product name
Diethyl Bromomalonate
Purity
>85.0%(GC)
Packaging
25g
Price
$20
Updated
2025/07/31
TCI Chemical
Product number
B1205
Product name
Diethyl Bromomalonate
Purity
>85.0%(GC)
Packaging
500g
Price
$175
Updated
2025/07/31
TRC
Product number
D443840
Product name
Diethyl Bromomalonate
Packaging
50g
Price
$50
Updated
2021/12/16
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DIETHYL BROMOMALONATE Chemical Properties,Usage,Production

Chemical Properties

CLEAR COLOURLESS TO SLIGHTLY YELLOW LIQUID

Uses

Diethyl bromomalonate is used in perfumes. It is also used to synthesize other compounds such as barbiturates, artificial flavorings, vitamin B1, and vitamin B6.

Uses

Diethyl Bromomalonate is a chemical constituent of the asymmetric cyclopropanation of chalcones. Also used in the preparation of nanaplatforms for NIR imaging-guided photodynamic therapy of cancer cel ls.

Synthesis

The Preparative Method of Diethyl Bromomalonate: by light-induced bromination of Diethyl Malonate with bromine in carbon tetrachloride; by treatment of diethyl malonate with bromotrichloromethane and 1,8-Diazabicyclo[5.4.0]undec-7-ene in benzene at 0 °C.

Purification Methods

Purify the ester by fractional distillation in a vacuum. IR: max 1800 and 1700cm-1 [Abramovitch Can J Chem 37 1146 1959, Bretschneider & Karpitschka Monatsh Chem 84 1091 1053]. [Beilstein 2 IV 1904.]

References

[1] Tetrahedron, 1983, vol. 39, # 21, p. 3493 - 3505
[2] RSC Advances, 2017, vol. 7, # 87, p. 55434 - 55440
[3] Bulletin de la Societe Chimique de France, 1986, # 6, p. 881 - 884
[4] Synthesis, 1980, # 2, p. 143 - 146
[5] Journal of Fluorine Chemistry, 2005, vol. 126, # 11-12, p. 1487 - 1492

DIETHYL BROMOMALONATE Preparation Products And Raw materials

Raw materials

Carbon tetrachloride Tetrahydrofuran Ethyl acetate Bromine Diethyl malonate PETROLEUM ETHER Sodium carbonate

Preparation Products

5-METHOXYBENZOFURAN-2-BORONIC ACID Benzofuran-2-carboxylic acid 3-Methylbenzofuran-2-carboxylic acid
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DIETHYL BROMOMALONATE Suppliers

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View Lastest Price from DIETHYL BROMOMALONATE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
diethyl bromomalonate 685-87-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-11-01
Henan Aochuang Chemical Co.,Ltd.
Product
DIETHYL BROMOMALONATE 685-87-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-17
Henan Fengda Chemical Co., Ltd
Product
ethyl bromomalonate 685-87-0
Price
US $8.00-0.80/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-01-22

685-87-0, DIETHYL BROMOMALONATERelated Search:

2-Bromomalonaldehyde (1,3-Dioxolan-2-ylmethyl)triphenylphosphonium bromide BROMOMALEIC ANHYDRIDE BROMOTRIS(TRIPHENYLPHOSPHINE)COPPER(I)& Bromoacetaldehyde diethyl acetal N-Bromoisocyanuric acid monosodium salt 1-BROMO-2-BUTANONE Ethyl nitroacetate Methyl Bromopyruvate Bromo-PEG2-acid Chloromethyl pivalate NEOPENTYLBORONIC ACID DIMETHYL BROMOMALONATE 2-Bromopropionic acid Diethyl 2-bromo-2-methylmalonate 2-Bromoethyl ethyl ether (R)-(+)-2-BROMOPROPIONIC ACID Ethyl bromoacetate

  • alpha-Bromomalonic ester
  • bromo-propanedioicacidiethylester
  • Diethyl 2-bromomalonate
  • Diethyl alpha-bromomalonate
  • Malonic acid, bromo-, diethyl ester
  • ETHYL BROMOMALONATE
  • DIETHYL BROMOMALONATE
  • BROMO DIETHYL MALONATE
  • BROMOMALONIC ACID DIETHYL ESTER
  • RARECHEM AL BI 0815
  • 2-BROMO-MALONIC ACID DIETHYL ESTER
  • DIETHYL BROMOMALONATE, ~85-95%
  • Diethyl bromomalonate, 95+%
  • Diethyl bromomalonate, 90-95%
  • Diethyl 2-bromopropane-1,3-dioate
  • Diethyl broMoMalonate, 90-95% 100ML
  • Diethyl broMoMalonate, 90-95% 25ML
  • Propanedioic acid, bromo-, diethyl ester
  • Diethyl bromomalonate, 90+%
  • Diethylebromomalonate
  • BroMine generation of diethyl Malonate
  • Diethyl bromomalonate 92%
  • Diethylbrommalonat
  • DiethylBromomalonate&gt
  • Propanedioic acid, 2-bromo-, 1,3-diethyl ester
  • Diethyl bromalonate
  • diethyl 2-bromopropanedioate
  • DI ETHYL BROMO MALONATE (DEBM)
  • Pregabalin Impurity 136
  • 685-87-0
  • C7H11BrO4
  • BrCHCO2CH2CH32
  • C6 to C7
  • Carbonyl Compounds
  • Building Blocks
  • HALOGEN
  • Esters
  • Organic Building Blocks
  • Building Blocks
  • C6 to C7
  • Carbonyl Compounds
  • Chemical Synthesis
  • Organic Building Blocks
  • C6 to C7
  • Carbonyl Compounds
  • Esters
  • bc0001