ChemicalBook > CAS DataBase List > tert-butyl 2-oxo-8-azaspiro[4.5]decane-8-carboxylate

tert-butyl 2-oxo-8-azaspiro[4.5]decane-8-carboxylate

Uses

Product Name: tert-butyl 2-oxo-8-azaspiro[4.5]decane-8-carboxylate
CAS No.: 1250994-14-9
Chemical Name: tert-butyl 2-oxo-8-azaspiro[4.5]decane-8-carboxylate
Synonyms: 8-Boc-8-azaspiro[4.5]decan-2-one;1-Boc-2-oxo-8-azaspiro-[4.5]decane-8-carboxylic acid;tert-butyl 2-oxo-8-azaspiro[4.5]decane-8-carboxylate;tert-butyl 3-oxo-8-azaspiro[4.5]decane-8-carboxylate;1,1-Dimethylethyl 2-oxo-8-azaspiro[4.5]decane-8-carboxylate;1-Boc-2-oxo-8-azaspiro[4.5]decane-8-carboxylic acid - [X13487];2-OXO-8-AZA-SPIRO[4.5]DECANE-8-CARBOXYLIC ACID TERT-BUTYL ESTER;8-Azaspiro[4.5]decane-8-carboxylic acid, 2-oxo-, 1,1-dimethylethyl ester
CBNumber: CB93033008
Molecular Formula: C14H23NO3
Formula Weight: 253.34
MOL File: 1250994-14-9.mol

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tert-butyl 2-oxo-8-azaspiro[4.5]decane-8-carboxylate Property

Boiling point:: 365.0±35.0 °C(Predicted)
Density: 1.10±0.1 g/cm3(Predicted)
storage temp.: Storage temp. 2-8°C
pka: -0.77±0.20(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C14H23NO3/c1-13(2,3)18-12(17)15-8-6-14(7-9-15)5-4-11(16)10-14/h4-10H2,1-3H3
InChIKey: ZXXJXEXKMUZKPG-UHFFFAOYSA-N
SMILES: C1C2(CCN(C(OC(C)(C)C)=O)CC2)CCC1=O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: 3543AQ
Product name: Tert-Butyl2-Oxo-8-Azaspiro[4.5]Decane-8-Carboxylate
Packaging: 250mg
Price: $330.8
Updated: 2021/12/16

Synthonix

Product number: X13487
Product name: 1-Boc-2-oxo-8-azaspiro[4.5]decane-8-carboxylicacid
Purity: 97.0%
Packaging: 500mg
Price: $400
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM1052255
Product name: TERT-BUTYL-2-OXO-8-AZASPIRO[4.5]DECANE-8-CARBOXYLATE
Purity: 95.00%
Packaging: 5MG
Price: $455.87
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-1-710
Product name: tert-Butyl 2-oxo-8-azaspiro[4.5]decane-8-carboxylate
Purity: 97.0%
Packaging: 1g
Price: $990
Updated: 2021/12/16

Matrix Scientific

Product number: 123518
Product name: 2-Oxo-8-azaspiro-[4,5]decane-8-carboxylicacid
Packaging: 1g
Price: $1782
Updated: 2021/12/16

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tert-butyl 2-oxo-8-azaspiro[4.5]decane-8-carboxylate Chemical Properties,Usage,Production

Uses

tert-butyl 2-oxo-8-azaspiro[4.5]decane-8-carboxylate is a useful research chemical.

Synthesis

80-11-5

203661-69-2

1250994-14-9

A 10% to 40% aqueous solution of potassium hydroxide (20 mL) was added to a solvent mixture of tetrahydrofuran and methanol containing tert-butyl-2-oxo-7-azaspiro[3.5]nonane-7-carboxylic acid (8.2 g). The solvent ratio was 10:1. In another vessel, N-methyl-N-nitroso-p-toluenesulfonamide (19.6 g) was dissolved in 300 mL of water and added slowly and dropwise at 0 °C to the above reaction solution. The reaction mixture was stirred at room temperature for 24 hours. Upon completion of the reaction, the system was cooled to room temperature and the reaction was quenched by the addition of acetic acid. Subsequently, the reaction mixture was rotary evaporated to dryness and the residue was dissolved in ethyl acetate (100 mL) and washed sequentially with water (100 mL) and saturated brine (100 mL). The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. Purification by column chromatography afforded ethyl tert-butyl-2-oxo-8-azaspiro[4.5]decane-8-carboxylate (6.6 g, yield: 72%).

References

[1] Patent: CN105272914, 2016, A. Location in patent: Paragraph 0010; 0014

tert-butyl 2-oxo-8-azaspiro[4.5]decane-8-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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1250994-14-9