ChemicalBook > CAS DataBase List > 2-Chloro-4-methyl-3-nitropyridine

2-Chloro-4-methyl-3-nitropyridine

Product Name: 2-Chloro-4-methyl-3-nitropyridine
CAS No.: 23056-39-5
Chemical Name: 2-Chloro-4-methyl-3-nitropyridine
Synonyms: 2-Chloro-4-Methyl-3-NP;2-CHLORO-3-NITRO-4-PICOLINE;2-Chloro-3-nitro-4-picoline,98%;2-CHLORO-3-NITRO-4-METHYLPYRIDINE;2-CHLORO-4-METHYL-3-NITROPYRIDINE;3-Nitro-2-chloro-4-methylpyridine;2,Chloro-4-Methyl-3-3-nitropyridine;2-Chloro-4-methyl-3-nitropyridine>PYRIDINE, 2-CHLORO-4-METHYL-3-NITRO-;2-Chloro-4-methyl-3-nitropyridine 98+%
CBNumber: CB9304053
Molecular Formula: C6H5ClN2O2
Formula Weight: 172.57
MOL File: 23056-39-5.mol

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2-Chloro-4-methyl-3-nitropyridine Property

Melting point:: 51-53 °C (lit.)
Boiling point:: 279.6±35.0 °C(Predicted)
Density: 1.406±0.06 g/cm3(Predicted)
Flash point:: >230 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka: -1.80±0.10(Predicted)
form: Powder
color: Yellow to beige
Sensitive: Hygroscopic
InChI: InChI=1S/C6H5ClN2O2/c1-4-2-3-8-6(7)5(4)9(10)11/h2-3H,1H3
InChIKey: JHARVUVBTAAPLA-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=CC(C)=C1[N+]([O-])=O
CAS DataBase Reference: 23056-39-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-21/22
Safety Statements: 26-37/39-36/37/39-36
RIDADR: UN2811
WGK Germany: 3
HazardClass: 6.1
PackingGroup: III
HS Code: 29333999

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 304360
Product name: 2-Chloro-4-methyl-3-nitropyridine
Purity: 99%
Packaging: 1g
Price: $108
Updated: 2023/01/07

TCI Chemical

Product number: C2012
Product name: 2-Chloro-4-methyl-3-nitropyridine
Purity: >98.0%(GC)
Packaging: 1g
Price: $25
Updated: 2025/07/31

TCI Chemical

Product number: C2012
Product name: 2-Chloro-4-methyl-3-nitropyridine
Purity: >98.0%(GC)
Packaging: 5g
Price: $47
Updated: 2025/07/31

Usbiological

Product number: 006395
Product name: 2-Chloro-4-methyl-3-nitropyridine
Packaging: 1g
Price: $418
Updated: 2021/12/16

TRC

Product number: C369145
Product name: 2-Chloro-4-methyl-3-nitropyridine
Packaging: 10g
Price: $260
Updated: 2021/12/16

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2-Chloro-4-methyl-3-nitropyridine Chemical Properties,Usage,Production

Chemical Properties

Light yellow Cryst

Uses

2-Chloro-4-methyl-3-nitropyridine is a cyclopropyldipyridodiazepinone derivative for use as non-nucleoside reverse transcriptase inhibitors.

Definition

2-Chloro-4-methyl-3-nitropyridine (2C4M3NP) is a nitropyridine derivative that could form an acceptor fragment of 2-adamantylamino-5-nitropyridine (AANP). This crystal shows a particularly large optical non-linearity. It is observed that the mean C-C (ring) bond distance calculated between the ring carbon atoms of 2C4M3NP is 1.387 Å. In X-ray data of pyridine, the mean C-C (ring) bond distance is 1.394 Å. The C-H bond distances are found to be 1.081 Å. The computed values of C-C (ring) and C-H are slightly higher than that of the experimental value. This is attributed to the substituents present in the pyridine. The C-C-C bond angle where the -Cl and -NO2 group is attached with the middle carbon is more than 120^? while the C-C-C bond angle where the -CH3 is substituted is less than 120^? in 2C4M3NP. The N-C-CH3 bond angle (116.3^。) is less than that of the C-C-CH3 (124.2^。) probably due to the weak hydrogen bond formed between the nitrogen and hydrogen of the methyl group[1].

General Description

Experimental FTIR and FT-Raman spectroscopic analysis of 2-chloro-4-methyl-3-nitropyridine was reported.

Synthesis

21901-18-8

23056-39-5

General procedure for the synthesis of 2-chloro-4-methyl-3-nitropyridine from 2-keto-3-nitro-4-methylpyridine: 2-keto-3-nitro-4-methylpyridine (13 g, 0.084 mol) was added to 50 mL of phosphorochloridic acid chloride and heated to reflux for 4 hours. Upon completion of the reaction, the excess phosphorus trichloride was removed by distillation. The crude product was recrystallized in 50 mL of 75% ethanol solution to give 11 g of white solid product in 75.3% yield. The melting point of the product was 51.7-52.1 °C (ethanol), which is consistent with the values reported in the literature (52.0-52.9 °C) [J.O.C., 1955, 20, 1729-1731].

References

[1] Arjunan, V. , et al. "A comparative study on vibrational, conformational and electronic structure of 2-chloro-4-methyl-3-nitropyridine and 2-chloro-6-methylpyridine." Spectrochimica Acta Part A Molecular & Biomolecular Spectroscopy 92.none(2012):305-317.

2-Chloro-4-methyl-3-nitropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

3-AMINO-2-FLUORO-4-PICOLINE

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View Lastest Price from 2-Chloro-4-methyl-3-nitropyridine manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 2-Chloro-4-methyl-3-nitropyridine 23056-39-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 10000KGS
Release date: 2025-05-29

Henan Fengda Chemical Co., Ltd

Product: 2-Chloro-4-methyl-3-nitropyridine 23056-39-5
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-08

Hebei Zhanyao Biotechnology Co. Ltd

Product: 2-Chloro-4-methyl-3-nitropyridine 23056-39-5
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 Tons
Release date: 2021-10-15

23056-39-5, 2-Chloro-4-methyl-3-nitropyridineRelated Search:

Methyl acrylate 2-Chloro-4-picoline Methyl acetate 4-Methyl-3-nitropyridine Bensulfuron methyl 2-Methyl-3-nitropyridine 3-Nitropyridine Kresoxim-methyl Methylparaben 2-Chloro-4-nitropyridine 2-Bromo-5-nitropyridine Azamethiphos 2,6-Lutidine 2,4,6-Collidine 2-Chloro-3-nitropyridine Methyl propyl carbonate Thiophanate-methyl 2-Chloro-5-chloromethylpyridine

2-Chloro-4-Methyl-3-NP

2-CHLORO-4-METHYL-3-NITROPYRIDINE

2-CHLORO-3-NITRO-4-METHYLPYRIDINE

2-CHLORO-3-NITRO-4-PICOLINE

PYRIDINE, 2-CHLORO-4-METHYL-3-NITRO-

2-CHLORO-3-NITRO-4-PICOLINE (2-CHLORO-4-METHYL-3-NITROPYRIDINE)

3-Nitro-2-chloro-4-methylpyridine

2-Chloro-3-nitro-4-picoline,98%

2-Chloro-4-methyl-3-nitropyridine 98+%

2,Chloro-4-Methyl-3-3-nitropyridine

2-Chloro-4-methyl-3-nitropyridine&gt

2-Chloro-4-methyl-3-nitropyridine ISO 9001：2015 REACH

23056-39-5

C6H5ClN2O2

Pyridines

Heterocyclic Building Blocks

Halogenated Heterocycles

Halopyridines

Chloropyridines

Building Blocks

Non-nucleoside Reverse Transcriptase

Amines

Aromatics

Heterocycles

Pyridine

Pyridines, Pyrimidines, Purines and Pteredines

Pyridine series

Heterocyclic Compounds

Pyridines

Chloropyridines

Halopyridines

Boronic Acid

C6Heterocyclic Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

Heterocycle-Pyridine series