Tos-PEG2-CH2CO2tBu

Product Name: Tos-PEG2-CH2CO2tBu
CAS No.: 1643957-24-7
Chemical Name: Tos-PEG2-CH2CO2tBu
Synonyms: Tos-PEG1-CH2-Boc;Tos-PEG2-CH2CO2tBu;Tos-PEG1-CH2COOtBu;tert-Butyl 2-[2-(tosyloxy)ethoxy]acetate;Tert butyl 2- (2- (p-toluenesulfonyloxy) ethoxy) acetate;Acetic acid, 2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethoxy]-, 1,1-dimethylethyl ester
CBNumber: CB93062686
Molecular Formula: C15H22O6S
Formula Weight: 330.4
MOL File: 1643957-24-7.mol

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Tos-PEG2-CH2CO2tBu Property

Boiling point:: 449.0±30.0 °C(Predicted)
Density: 1.183±0.06 g/cm3(Predicted)
storage temp.: Store at Room Tem.
Appearance: colorless liquid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-22282
Product name: Tos-PEG2-CH2CO2tBu
Purity: 98%
Packaging: 250mg
Price: $350
Updated: 2021/12/16

BroadPharm

Product number: BP-22282
Product name: Tos-PEG2-CH2CO2tBu
Purity: 98%
Packaging: 1g
Price: $890
Updated: 2021/12/16

BroadPharm

Product number: BP-22282
Product name: Tos-PEG2-CH2CO2tBu
Purity: 98%
Packaging: 2g
Price: $1325
Updated: 2021/12/16

Ambeed

Product number: A966140
Product name: tert-Butyl2-[2-(tosyloxy)ethoxy]acetate
Purity: 95+%
Packaging: 50mg
Price: $122
Updated: 2021/12/16

Ambeed

Product number: A966140
Product name: tert-Butyl2-[2-(tosyloxy)ethoxy]acetate
Purity: 95+%
Packaging: 100mg
Price: $153
Updated: 2021/12/16

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Tos-PEG2-CH2CO2tBu Chemical Properties,Usage,Production

Description

Tos-PEG2-CH2CO2tBu is a PEG linker containing a t-butyl ester and a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The tosyl group is a very good leaving group for nucleophilic substitution reactions.

Uses

Tos-PEG1-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs; Alkyl/ether

References

[1] Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34. DOI:10.1038/s12276-018-0065-6

Tos-PEG2-CH2CO2tBu Preparation Products And Raw materials

Raw materials

Preparation Products

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Tos-PEG2-CH2CO2tBu Suppliers

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1643957-24-7, Tos-PEG2-CH2CO2tBuRelated Search:

Tos-PEG4-acid Tos-PEG5 t-butyl ester Tos-PEG2-t-butyl ester Tos-PEG4-CH2CO2H Tos-PEG4-t-butyl ester Tos-PEG6-t-Butyl ester Tos-PEG3-CH2CO2tBu Tos-PEG5-CH2CO2H Tos-PEG5-CH2CO2t-butyl ester Tos-PEG3-CH2CO2H

Tos-PEG2-CH2CO2tBu

tert-Butyl 2-[2-(tosyloxy)ethoxy]acetate

Tos-PEG1-CH2-Boc

Acetic acid, 2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethoxy]-, 1,1-dimethylethyl ester

Tert butyl 2- (2- (p-toluenesulfonyloxy) ethoxy) acetate

Tos-PEG1-CH2COOtBu

1643957-24-7