Aminooxy-PEG2-azide
- Product Name
- Aminooxy-PEG2-azide
- CAS No.
- 1043426-13-6
- Chemical Name
- Aminooxy-PEG2-azide
- Synonyms
- Aminooxy-PEG2-azide;O-(2-(2-(2-Azidoethoxy)ethoxy)ethyl)hydroxylamine
- CBNumber
- CB93162832
- Molecular Formula
- C6H14N4O3
- Formula Weight
- 190.2
- MOL File
- 1043426-13-6.mol
Aminooxy-PEG2-azide Property
- solubility
- Soluble in Water, DMSO, DMF, DCM
- form
- Liquid
- color
- Colorless to light yellow
N-Bromosuccinimide Price
- Product number
- BP-23103
- Product name
- Aminooxy-PEG2-azide
- Purity
- 95%
- Packaging
- 500mg
- Price
- $980
- Updated
- 2021/12/16
Aminooxy-PEG2-azide Chemical Properties,Usage,Production
Description
Aminooxy-PEG2-azide contain an azide and an aminooxy group. The aminooxy group reacts with an aldehyde or ketone group to form a oxime linkage. The azide group enables Click Chemistry. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended.
Biological Activity
Aminooxy-PEG2-azide is a PROTAC linker belonging to the PEG class, which can be used to synthesize PROTAC molecules.It is also a non-cleavable ADC linker containing 2-unit PEG, which can be used to synthesize antibody drug conjugates (ADCs).
in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
| PEGs
| Non-cleavable
|
Aminooxy-PEG2-azide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Aminooxy-PEG2-azide manufacturers
- Product
- Aminooxy-PEG2-azide 1043426-13-6
- Price
- US $0.00/mg
- Min. Order
- 500mg
- Purity
- >98.00%
- Supply Ability
- 500mg
- Release date
- 2024-04-02