Azido-PEG3-Sulfone-PEG4-acid
- Product Name
- Azido-PEG3-Sulfone-PEG4-acid
- CAS No.
- 2055024-42-3
- Chemical Name
- Azido-PEG3-Sulfone-PEG4-acid
- Synonyms
- Azido-PEG3-Sulfone-PEG4-acid;4,7,10,13,19,22,25-Heptoxa-16-thiaheptacosanoic acid, 27-azido-, 16,16-dioxide
- CBNumber
- CB93162872
- Molecular Formula
- C19H37N3O11S
- Formula Weight
- 515.58
- MOL File
- 2055024-42-3.mol
N-Bromosuccinimide Price
- Product number
- BP-23236
- Product name
- Azido-PEG3-Sulfone-PEG4-acid
- Purity
- 98%
- Packaging
- 250mg
- Price
- $540
- Updated
- 2021/12/16
- Product number
- BP-23236
- Product name
- Azido-PEG3-Sulfone-PEG4-acid
- Purity
- 98%
- Packaging
- 500mg
- Price
- $750
- Updated
- 2021/12/16
Azido-PEG3-Sulfone-PEG4-acid Chemical Properties,Usage,Production
Description
Azido-PEG3-Sulfone-PEG4-acid is a PEG linker containing one azide group with a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) forming a stable amide bond. The azide group enables Click Chemistry. The hydrophilic PEG spacer increases solubility in aqueous media.
Uses
Azido-PEG3-Sulfone-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG3-Sulfone-PEG4-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Azido-PEG3-Sulfone-PEG4-acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Azido-PEG3-Sulfone-PEG4-acid manufacturers
- Product
- Azido-PEG3-Sulfone-PEG4-acid 2055024-42-3
- Price
- US $0.00/mg
- Min. Order
- 500mg
- Purity
- >95.00%
- Supply Ability
- 500mg
- Release date
- 2024-03-28