ChemicalBook > CAS DataBase List > ML385

ML385

Product Name
ML385
CAS No.
846557-71-9
Chemical Name
ML385
Synonyms
ML38;ML385;CS-2542;ML 385; ML-385;Ferroptosis,ML385,Inhibitor,inhibit,ML-385,Keap1-Nrf2,ML 385;N-[4-[2,3-Dihydro-1-(2-methylbenzoyl)-1H-indol-5-yl]-5-methyl-2-thiazolyl]-1,3-benzodioxole-5-acetamide;1,3-Benzodioxole-5-acetamide, N-[4-[2,3-dihydro-1-(2-methylbenzoyl)-1H-indol-5-yl]-5-methyl-2-thiazolyl]-;2-(1,3-benzodioxol-5-yl)-N-[5-methyl-4-[1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl]-1,3-thiazol-2-yl]acetamide
CBNumber
CB93168748
Molecular Formula
C29H25N3O4S
Formula Weight
511.59
MOL File
846557-71-9.mol
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ML385 Property

Density 
1.374±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO:31.4(Max Conc. mg/mL);61.38(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);58.64(Max Conc. mM)
DMF:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.49(Max Conc. mM)
form 
powder
pka
8.92±0.50(Predicted)
color 
white to beige
InChIKey
LINHYWKZVCNAMQ-UHFFFAOYSA-N
SMILES
O1C2=CC=C(CC(NC3=NC(C4C=CC5=C(C=4)CCN5C(=O)C4=CC=CC=C4C)=C(C)S3)=O)C=C2OC1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1833
Product name
ML385
Purity
≥98% (HPLC)
Packaging
5MG
Price
$107
Updated
2023/06/20
Sigma-Aldrich
Product number
SML1833
Product name
ML385
Purity
≥98% (HPLC)
Packaging
25MG
Price
$434
Updated
2023/06/20
Cayman Chemical
Product number
21114
Product name
ML-385
Purity
≥98%
Packaging
5mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
21114
Product name
ML-385
Purity
≥98%
Packaging
10mg
Price
$176
Updated
2024/03/01
Cayman Chemical
Product number
21114
Product name
ML-385
Purity
≥98%
Packaging
25mg
Price
$388
Updated
2024/03/01
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ML385 Chemical Properties,Usage,Production

Biochem/physiol Actions

ML385 inihbits the activity of the Nrf2 transcription factor by binding to Neh1, a CNC-bZIP domain that allows Nrf2 to heterodimerize with small Maf proteins, blocking NRF2 transcriptional activity. Much research has been done on activating Nrf2 because it induces cytoprotective antioxidant genes. However, some cancer cells may use Nrf2 similarly for their survival. Nrf2 is overexpressed in certain cancers such as non-small cell lung cancer (NSCLC) often due to loss of function mutations in KEAP1, which targets Nrf2 for proteasomal degradation. ML385 was found to have anti-tumor activity with specificity and selectivity for NSCLC cells with KEAP1 mutations.

storage

Store at -20°C

ML385 Preparation Products And Raw materials

Raw materials

Preparation Products

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ML385 Suppliers

China 83 India 1 United Kingdom 1 United States 6 Global 91
Shanghai Chaolan Chemical Technology Center
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846557-71-9, ML385Related Search:

ML188 ML418 [4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone ML213 N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine PTP1B-IN-2 ML264 ML216 ML365 ML 141 ML355 M348 ml390 (2,4,6-Trichloro-phenoxy)-acetic acid (1H-pyrrol-2-ylmethylene)-hydrazide 5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one ML277 ML364 VU0456810

  • ML385
  • CS-2542
  • ML 385; ML-385
  • N-[4-[2,3-Dihydro-1-(2-methylbenzoyl)-1H-indol-5-yl]-5-methyl-2-thiazolyl]-1,3-benzodioxole-5-acetamide
  • 2-(1,3-benzodioxol-5-yl)-N-[5-methyl-4-[1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl]-1,3-thiazol-2-yl]acetamide
  • 1,3-Benzodioxole-5-acetamide, N-[4-[2,3-dihydro-1-(2-methylbenzoyl)-1H-indol-5-yl]-5-methyl-2-thiazolyl]-
  • Ferroptosis,ML385,Inhibitor,inhibit,ML-385,Keap1-Nrf2,ML 385
  • ML38
  • 846557-71-9
  • api