ML385
- Product Name
- ML385
- CAS No.
- 846557-71-9
- Chemical Name
- ML385
- Synonyms
- ML38;ML385;CS-2542;ML 385; ML-385;Ferroptosis,ML385,Inhibitor,inhibit,ML-385,Keap1-Nrf2,ML 385;N-[4-[2,3-Dihydro-1-(2-methylbenzoyl)-1H-indol-5-yl]-5-methyl-2-thiazolyl]-1,3-benzodioxole-5-acetamide;1,3-Benzodioxole-5-acetamide, N-[4-[2,3-dihydro-1-(2-methylbenzoyl)-1H-indol-5-yl]-5-methyl-2-thiazolyl]-;2-(1,3-benzodioxol-5-yl)-N-[5-methyl-4-[1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl]-1,3-thiazol-2-yl]acetamide
- CBNumber
- CB93168748
- Molecular Formula
- C29H25N3O4S
- Formula Weight
- 511.59
- MOL File
- 846557-71-9.mol
ML385 Property
- Density
- 1.374±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO:31.4(Max Conc. mg/mL);61.38(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);58.64(Max Conc. mM)
DMF:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.49(Max Conc. mM) - form
- powder
- pka
- 8.92±0.50(Predicted)
- color
- white to beige
- InChIKey
- LINHYWKZVCNAMQ-UHFFFAOYSA-N
- SMILES
- O1C2=CC=C(CC(NC3=NC(C4C=CC5=C(C=4)CCN5C(=O)C4=CC=CC=C4C)=C(C)S3)=O)C=C2OC1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML1833
- Product name
- ML385
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $107
- Updated
- 2023/06/20
- Product number
- SML1833
- Product name
- ML385
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $434
- Updated
- 2023/06/20
- Product number
- 21114
- Product name
- ML-385
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- 21114
- Product name
- ML-385
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $176
- Updated
- 2024/03/01
- Product number
- 21114
- Product name
- ML-385
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $388
- Updated
- 2024/03/01
ML385 Chemical Properties,Usage,Production
Biochem/physiol Actions
ML385 inihbits the activity of the Nrf2 transcription factor by binding to Neh1, a CNC-bZIP domain that allows Nrf2 to heterodimerize with small Maf proteins, blocking NRF2 transcriptional activity. Much research has been done on activating Nrf2 because it induces cytoprotective antioxidant genes. However, some cancer cells may use Nrf2 similarly for their survival. Nrf2 is overexpressed in certain cancers such as non-small cell lung cancer (NSCLC) often due to loss of function mutations in KEAP1, which targets Nrf2 for proteasomal degradation. ML385 was found to have anti-tumor activity with specificity and selectivity for NSCLC cells with KEAP1 mutations.
storage
Store at -20°C