ML385

Product Name: ML385
CAS No.: 846557-71-9
Chemical Name: ML385
Synonyms: ML38;ML385;CS-2542;ML 385; ML-385;Ferroptosis,ML385,Inhibitor,inhibit,ML-385,Keap1-Nrf2,ML 385;N-[4-[2,3-Dihydro-1-(2-methylbenzoyl)-1H-indol-5-yl]-5-methyl-2-thiazolyl]-1,3-benzodioxole-5-acetamide;1,3-Benzodioxole-5-acetamide, N-[4-[2,3-dihydro-1-(2-methylbenzoyl)-1H-indol-5-yl]-5-methyl-2-thiazolyl]-;2-(1,3-benzodioxol-5-yl)-N-[5-methyl-4-[1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl]-1,3-thiazol-2-yl]acetamide
CBNumber: CB93168748
Molecular Formula: C29H25N3O4S
Formula Weight: 511.59
MOL File: 846557-71-9.mol

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ML385 Property

Density: 1.374±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO:31.4(Max Conc. mg/mL);61.38(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);58.64(Max Conc. mM)
DMF:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.49(Max Conc. mM)
form: powder
pka: 8.92±0.50(Predicted)
color: white to beige
InChIKey: LINHYWKZVCNAMQ-UHFFFAOYSA-N
SMILES: O1C2=CC=C(CC(NC3=NC(C4C=CC5=C(C=4)CCN5C(=O)C4=CC=CC=C4C)=C(C)S3)=O)C=C2OC1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1833
Product name: ML385
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $107
Updated: 2023/06/20

Sigma-Aldrich

Product number: SML1833
Product name: ML385
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $434
Updated: 2023/06/20

Cayman Chemical

Product number: 21114
Product name: ML-385
Purity: ≥98%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 21114
Product name: ML-385
Purity: ≥98%
Packaging: 10mg
Price: $176
Updated: 2024/03/01

Cayman Chemical

Product number: 21114
Product name: ML-385
Purity: ≥98%
Packaging: 25mg
Price: $388
Updated: 2024/03/01

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ML385 Chemical Properties,Usage,Production

Biochem/physiol Actions

ML385 inihbits the activity of the Nrf2 transcription factor by binding to Neh1, a CNC-bZIP domain that allows Nrf2 to heterodimerize with small Maf proteins, blocking NRF2 transcriptional activity. Much research has been done on activating Nrf2 because it induces cytoprotective antioxidant genes. However, some cancer cells may use Nrf2 similarly for their survival. Nrf2 is overexpressed in certain cancers such as non-small cell lung cancer (NSCLC) often due to loss of function mutations in KEAP1, which targets Nrf2 for proteasomal degradation. ML385 was found to have anti-tumor activity with specificity and selectivity for NSCLC cells with KEAP1 mutations.

storage

Store at -20°C

ML385 Preparation Products And Raw materials

Raw materials

Preparation Products

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ML385 Suppliers

China 87 India 1 United Kingdom 1 United States 7 Global 96

A.J Chemicals

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Email: sales@ajchem.in
Country: India
ProdList: 6100
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846557-71-9, ML385Related Search:

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ML385

CS-2542

ML 385; ML-385

N-[4-[2,3-Dihydro-1-(2-methylbenzoyl)-1H-indol-5-yl]-5-methyl-2-thiazolyl]-1,3-benzodioxole-5-acetamide

2-(1,3-benzodioxol-5-yl)-N-[5-methyl-4-[1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl]-1,3-thiazol-2-yl]acetamide

1,3-Benzodioxole-5-acetamide, N-[4-[2,3-dihydro-1-(2-methylbenzoyl)-1H-indol-5-yl]-5-methyl-2-thiazolyl]-

Ferroptosis,ML385,Inhibitor,inhibit,ML-385,Keap1-Nrf2,ML 385

ML38

846557-71-9

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