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ML385

Product Name
ML385
CAS No.
846557-71-9
Chemical Name
ML385
Synonyms
ML38;ML385;CS-2542;ML 385; ML-385;ML385, 10 mM in DMSO;Ferroptosis,ML385,Inhibitor,inhibit,ML-385,Keap1-Nrf2,ML 385;N-[4-[2,3-Dihydro-1-(2-methylbenzoyl)-1H-indol-5-yl]-5-methyl-2-thiazolyl]-1,3-benzodioxole-5-acetamide;1,3-Benzodioxole-5-acetamide, N-[4-[2,3-dihydro-1-(2-methylbenzoyl)-1H-indol-5-yl]-5-methyl-2-thiazolyl]-;2-(1,3-benzodioxol-5-yl)-N-[5-methyl-4-[1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl]-1,3-thiazol-2-yl]acetamide
CBNumber
CB93168748
Molecular Formula
C29H25N3O4S
Formula Weight
511.59
MOL File
846557-71-9.mol
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ML385 Property

Density 
1.374±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO:31.4(Max Conc. mg/mL);61.38(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);58.64(Max Conc. mM)
DMF:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.49(Max Conc. mM)
form 
powder
pka
8.92±0.50(Predicted)
color 
white to beige
InChIKey
LINHYWKZVCNAMQ-UHFFFAOYSA-N
SMILES
O1C2=CC=C(CC(NC3=NC(C4C=CC5=C(C=4)CCN5C(=O)C4=CC=CC=C4C)=C(C)S3)=O)C=C2OC1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1833
Product name
ML385
Purity
≥98% (HPLC)
Packaging
5MG
Price
$110.56
Updated
2025/07/31
Sigma-Aldrich
Product number
SML1833
Product name
ML385
Purity
≥98% (HPLC)
Packaging
25MG
Price
$477
Updated
2025/07/31
Cayman Chemical
Product number
21114
Product name
ML-385
Purity
≥98%
Packaging
5mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
21114
Product name
ML-385
Purity
≥98%
Packaging
10mg
Price
$176
Updated
2024/03/01
Cayman Chemical
Product number
21114
Product name
ML-385
Purity
≥98%
Packaging
25mg
Price
$388
Updated
2024/03/01
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ML385 Chemical Properties,Usage,Production

Uses

ML385 is a specific nuclear factor erythroid 2-related factor 2 (NRF2) inhibitor with an IC50 of 1.9 μM.

Biochem/physiol Actions

ML385 inihbits the activity of the Nrf2 transcription factor by binding to Neh1, a CNC-bZIP domain that allows Nrf2 to heterodimerize with small Maf proteins, blocking NRF2 transcriptional activity. Much research has been done on activating Nrf2 because it induces cytoprotective antioxidant genes. However, some cancer cells may use Nrf2 similarly for their survival. Nrf2 is overexpressed in certain cancers such as non-small cell lung cancer (NSCLC) often due to loss of function mutations in KEAP1, which targets Nrf2 for proteasomal degradation. ML385 was found to have anti-tumor activity with specificity and selectivity for NSCLC cells with KEAP1 mutations.

in vivo

ML385 in combination with carboplatin leads to a significant reduction in tumor cell proliferation, demonstrated by fewer Ki-67 positive cells. Tumor samples treated with ML385 show a significant reduction in NRF2 protein level and its downstream target genes[1]. ML385 (intraperitoneal injection; 30 mg/kg; 7 days) weakens the therapeutic effects of MSC-Exo on inflammation-induced astrocytic activation (e.g., reduced reactive astrogliosis, NF-κB deactivation) in mice[3].

Animal Model:8-week-old C57B/6 male mice[3]
Dosage:30 mg/kg; 7 days
Administration:Intraperitoneal injection
Result:Reversed inhibition of MSC-Exo on hippocampal astrocytic activation in vivo.

storage

Store at -20°C

References

[1] Singh A, et al. Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors. ACS Chem Biol. 2016 Nov 18;11(11):3214-3225. DOI:10.1021/acschembio.6b00651
[2] Xinnong Liu, et al. Isoliquiritigenin ameliorates acute pancreatitis in mice via inhibition of oxidative stress and modulation of the Nrf2/HO-1 pathway. Oxid Med Cell Longev. 20 March 2018.
[3] Xian P, et al. Mesenchymal?stem?cell-derived?exosomes?as a?nanotherapeutic?agent?for?amelioration?of?inflammation-induced?astrocyte?alterations?in?mice.Theranostics.?2019 Aug 14;9(20):5956-5975. DOI:10.7150/thno.33872

ML385 Preparation Products And Raw materials

Raw materials

Preparation Products

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ML385 Suppliers

China 139 India 1 United Kingdom 1 United States 8 Global 149
A.J Chemicals
Tel
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Fax
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Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
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846557-71-9, ML385Related Search:

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  • ML385
  • CS-2542
  • ML 385; ML-385
  • N-[4-[2,3-Dihydro-1-(2-methylbenzoyl)-1H-indol-5-yl]-5-methyl-2-thiazolyl]-1,3-benzodioxole-5-acetamide
  • 2-(1,3-benzodioxol-5-yl)-N-[5-methyl-4-[1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl]-1,3-thiazol-2-yl]acetamide
  • 1,3-Benzodioxole-5-acetamide, N-[4-[2,3-dihydro-1-(2-methylbenzoyl)-1H-indol-5-yl]-5-methyl-2-thiazolyl]-
  • Ferroptosis,ML385,Inhibitor,inhibit,ML-385,Keap1-Nrf2,ML 385
  • ML38
  • ML385, 10 mM in DMSO
  • 846557-71-9
  • api