5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL

Product Name: 5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL
CAS No.: 566-26-7
Chemical Name: 5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL
Synonyms: 7alpha-Cholesterol;7α-Hydroxy Cholesterol;Cholest-5-En-3Β,7Α-Diol;Cholesterol Impurity 28;5-CHOLESTEN-3β, 7α-DIOL;7-ALPHA-HYDROXYCHOLESTEROL;7a-Hydroxycholest-5-en-3ol;7-alfa-Hydroxy-Cholesterol;3β,7α-Dihydroxycholest-5-ene;(3,7a)-Cholest-5-ene-3,7-diol
CBNumber: CB9321715
Molecular Formula: C27H46O2
Formula Weight: 402.66
MOL File: 566-26-7.mol

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5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL Property

Melting point:: 168-170°C
Boiling point:: 515.3±38.0 °C(Predicted)
Density: 1.03±0.1 g/cm3(Predicted)
storage temp.: Refrigerator
solubility: Soluble in DMSO or in Ethanol.
form: solid
pka: 14.11±0.70(Predicted)
color: White or pale yellow
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: H917990
Product name: 7α-HydroxyCholesterol
Packaging: 5mg
Price: $305
Updated: 2021/12/16

IsoSciences

Product number: 13410
Product name: 7α-Hydroxycholesterol
Purity: ≥98%
Packaging: 1mg
Price: $195
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: SHG0005077
Product name: CHOLEST-5-EN-3-BETA-7-ALPHA-DIOL
Purity: 95.00%
Packaging: 5MG
Price: $497.13
Updated: 2021/12/16

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5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL Chemical Properties,Usage,Production

Description

7α-Hydroxycholesterol (566-26-7) is a metabolite resulting from the action of cholesterol 7α-hydroxylase on cholesterol. 7α-Hydroxycholesterol is the first intermediate and a rate limiting step in the major pathway for bile acid synthesis in humans.??A pro-inflammatory mediator which upregulates production of CCL2 and MMP9 in macrophages and may promote progression of atherosclerosis.2,3?Possible biomarker for cellular lipid peroxidation.4

Chemical Properties

White Solid

Uses

Secondary metabolite of Cholesterol.

Definition

ChEBI: The 7alpha-hydroxy derivative of cholesterol.

References

[1] WILLIAM C. DUANE Norman B J. Conversion of 7α-hydroxycholesterol to bile acid in human subjects: Is there an alternate pathway favoring cholic acid synthesis?[J]. Journal of Laboratory and Clinical Medicine, 2002, 139 2: Pages 109-115. DOI:10.1067/mlc.2002.121023
[2] SUN-MI KIM . 7α-Hydroxycholesterol induces inflammation by enhancing production of chemokine (C–C motif) ligand 2[J]. Biochemical and biophysical research communications, 2015, 467 4: Pages 879-884. DOI:10.1016/j.bbrc.2015.10.050
[3] SUN-MI KIM . 27-Hydroxycholesterol and 7alpha-hydroxycholesterol trigger a sequence of events leading to migration of CCR5-expressing Th1 lymphocytes[J]. Toxicology and applied pharmacology, 2014, 274 3: Pages 462-470. DOI:10.1016/j.taap.2013.12.007
[4] YOSHIRO SAITO Noriko N. 7-Hydroxycholestrol as a possible biomarker of cellular lipid peroxidation: Difference between cellular and plasma lipid peroxidation[J]. Biochemical and biophysical research communications, 2014, 446 3: Pages 741-744. DOI:10.1016/j.bbrc.2013.12.083

5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL Preparation Products And Raw materials

Raw materials

Preparation Products

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5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL Suppliers

Canada 1 China 79 India 4 United States 10 Global 94

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566-26-7, 5-CHOLESTEN-3-BETA, 7-ALPHA-DIOLRelated Search:

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7-ALPHA-HYDROXYCHOLESTEROL

5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL

cholest-5-en-3 beta,7 alpha-diol

(3,7a)-Cholest-5-ene-3,7-diol

7a-Hydroxycholest-5-en-3ol

3β,7α-Dihydroxycholest-5-ene

7alpha-Cholesterol

Cholest-5-ene-3,7-diol, (3beta,7alpha)-

Cholest-5-ene-3,7-diol, (3b,7a)-

7-alfa-Hydroxy-Cholesterol

7α-Hydroxycholesterol (Solution)

Cholest-5-ene-3,7-diol, (3β,7α)-

7α-Hydroxy Cholesterol

Cholest-5-En-3Β,7Α-Diol

Cholesterol Impurity 28

(3beta,7alpha)-cholest-5-ene-3,7-diol

peroxidation,Cholesterol,7α-Hydroxycholesterol,non-enzymatic,oxide,inhibit,biomarker,enzymatic,lipid,oxidation,Inhibitor,7α Hydroxycholesterol,7αHydroxycholesterol

5-CHOLESTEN-3β, 7α-DIOL

7alpha-Hydroxycholesterol, Bile acid precursor

7α-Hydroxycholesterol, 10 mM in DMSO

566-26-7

Intermediates & Fine Chemicals

Metabolites & Impurities

Pharmaceuticals

Steroids