WY-14643
- Product Name
- WY-14643
- CAS No.
- 50892-23-4
- Chemical Name
- WY-14643
- Synonyms
- CS-737;WY-14643;Pirinixic;NSC 310038;wyeth14,643;Chloro Acid;pirnixicacid;99.0%(LC&PIRINIXIC ACID;WY-14643/WY14643
- CBNumber
- CB9345027
- Molecular Formula
- C14H14ClN3O2S
- Formula Weight
- 323.8
- MOL File
- 50892-23-4.mol
WY-14643 Property
- Melting point:
- 155°C
- Boiling point:
- 514.4±50.0 °C(Predicted)
- Density
- 1.2984 (rough estimate)
- refractive index
- 1.5630 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Soluble in DMSO (up to 40 mg/ml).
- form
- White crystalline solid
- pka
- 2.99±0.10(Predicted)
- color
- Off-white
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 6 months.
Safety
- Hazard Codes
- T
- Risk Statements
- 45-22-36/37/38
- Safety Statements
- 53-26-36/37/39-45
- WGK Germany
- 3
- RTECS
- AG2915000
- HS Code
- 2933.59.9500
- Hazardous Substances Data
- 50892-23-4(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H350May cause cancer
- Precautionary statements
-
P201Obtain special instructions before use.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- C7081
- Product name
- WY-14643
- Packaging
- 10mg
- Price
- $60.3
- Updated
- 2024/03/01
- Product number
- C7081
- Product name
- WY-14643
- Packaging
- 50mg
- Price
- $194
- Updated
- 2024/03/01
- Product number
- C1323
- Product name
- [4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic Acid
- Purity
- >99.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $151
- Updated
- 2024/03/01
- Product number
- C1323
- Product name
- [4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic Acid
- Purity
- >99.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $454
- Updated
- 2024/03/01
- Product number
- 70730
- Product name
- Wy 14643
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $16
- Updated
- 2024/03/01
WY-14643 Chemical Properties,Usage,Production
Description
WY-14643 (50892-23-4) is a selective PPARα agonist (EC50=0.63, 32 and >100 μM for PPARα,γ and δ, respectively).1? Displays anti-inflammatory activity2 and reduces LPS-induced inflammation in alveolar epithelial cells3. Induces “browning” of white adipocytes in combined treatment with retinoic acid.4? Stimulates ADAM10-mediated proteolysis of? amyloid precursor protein in a mouse model.5 Down regulates NFkB transcriptional activity. Review.6
Uses
A highly potent PPARα agonist
Uses
WY-14643 has been used:
- as a positive control for transfection and luciferase assay
- to stimulate bone marrow–derived macrophages (BMDM) for autophagic flux analysis
- to analyze the regulation of fatty acid metabolism-immune nexus (FAMIN) expression in cell culture
Definition
ChEBI: Pirinixic acid is a member of pyrimidines, an organochlorine compound and an aryl sulfide. It is functionally related to an acetic acid.
General Description
WY-14643 prevents lipopolysaccharide (LPS)-induced inflammation in synovial fibroblasts. It protects cortical neurons from pro-inflammatory mediator-induced cell injuries. WY-14643 has inhibitory effects on pro-inflammatory responses in microglia. It improves oxido-nitrosative stress in disease models and reduces the generation of reactive oxygen species (ROS), nitric oxide (NO) and lipid peroxidation end-products in the brain.
Biological Activity
Selective PPAR α agonist (EC 50 values are 0.63, 32 and > 100 μ M at PPAR α , PPAR γ and PPAR δ respectively). Negatively inhibits NF- κ B transcriptional activity and decreases the inflammatory response in vitro and in vivo .
Biochem/physiol Actions
Selective PPARα agonist.
Safety Profile
Moderately toxic by ingestion. Suspected carcinogen with experimental carcinogenic and tumorigenic data. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cl-, NOx and SOx
storage
Store at RT
References
1) Forman et al. (1997), Hypolipidemic drugs, polyunsaturated fatty acids and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta; Proc. Natl. Acad. Sci. USA, 94 4312 2) Devchand et al. (1996), The PPARalpha-leukotriene B4 pathway to inflammation control; Nature, 384 39 3) Heckler et al. (2015), PPAR-a activation reduced LPS-induced inflammation in alveolar epithelial cells; Exp. Lung Res., 41 393 4) Wang et al. (2015), WY14643 combined with all-trans retinoic acid acts via p38 MAPK to induce “browning” of white adipocytes in mice; Genet. Mol. Res., 14 6978 5) Corbett et al. (2015), Activation of peroxisome proliferator-activated receptor alpha stimulates ADAM10-mediated proteolysis of APP; Proc. Natl. Acad. Sci. USA, 112 8445 6) Merk et al. (2015), Pirinixic acids: flexible fatty acid mimetics with various biological activities; Future Med. Chem., 7 1597
WY-14643 Preparation Products And Raw materials
Raw materials
Preparation Products
WY-14643 Suppliers
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View Lastest Price from WY-14643 manufacturers
- Product
- WY-14643 50892-23-4
- Price
- US $8.00/KG
- Min. Order
- 1KG
- Purity
- ＞98% HPLC
- Supply Ability
- 20 tons
- Release date
- 2020-02-17