2-Bromo-5-chloropyridine
- Product Name
- 2-Bromo-5-chloropyridine
- CAS No.
- 40473-01-6
- Chemical Name
- 2-Bromo-5-chloropyridine
- Synonyms
- IFLAB-BB F2124-0201;2-broMo-5-chloropyridin;2-Brome-5-chloropyridine;2-BROMO-5-CHLOROPYRIDINE;5-Chloro-2-bromopyridine;2-BroMoo-5-chloropyridine;2-Beromo-5-chloropyridine;Pyridine, 2-bromo-5-chloro-;2-broMo -5-chlorine pyridine;2-Bromo-5-chloropyridine,98%
- CBNumber
- CB9384264
- Molecular Formula
- C5H3BrClN
- Formula Weight
- 192.44
- MOL File
- 40473-01-6.mol
2-Bromo-5-chloropyridine Property
- Melting point:
- 65-69 °C
- Boiling point:
- 128 °C / 16mmHg
- Density
- 1.736±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- -1.49±0.10(Predicted)
- form
- Powder
- color
- Beige to yellow-brown
- Water Solubility
- Slightly soluble in water.
- InChI
- InChI=1S/C5H3BrClN/c6-5-2-1-4(7)3-8-5/h1-3H
- InChIKey
- BZUUVQCSPHPUQA-UHFFFAOYSA-N
- SMILES
- C1(Br)=NC=C(Cl)C=C1
- CAS DataBase Reference
- 40473-01-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 36/37/38-20/22-20/2236/37/38-20/21/22
- Safety Statements
- 36/37/39-26-22-22 26 36/37/39-36
- RIDADR
- Cool, dry,tightly closed
- HazardClass
- IRRITANT
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- T138401
- Product name
- 2-BROMO-5-CHLOROPYRIDINE
- Purity
- AldrichCPR
- Packaging
- 5MG
- Price
- $143
- Updated
- 2025/07/31
- Product number
- B2763
- Product name
- 2-Bromo-5-chloropyridine
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $16
- Updated
- 2025/07/31
- Product number
- B2763
- Product name
- 2-Bromo-5-chloropyridine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $37
- Updated
- 2025/07/31
- Product number
- FB64674
- Product name
- 2-Bromo-5-chloropyridine
- Packaging
- 500g
- Price
- $195
- Updated
- 2021/12/16
- Product number
- 011182
- Product name
- 2-Bromo-5-chloropyridine
- Purity
- 98%
- Packaging
- 500g
- Price
- $195
- Updated
- 2021/12/16
2-Bromo-5-chloropyridine Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powder
Uses
It is an important organic intermediate used in agrochemicals, pharmaceuticals and dyestuff fields. It is also used in the synthesis of novel halopyridinylboronic acids and esters.
Synthesis
1072-98-6
40473-01-6
General procedure for the synthesis of 2-bromo-5-chloropyridine from 2-amino-5-chloropyridine: [Ref. Example 25] 5-(5-chloro-2-pyridinyl)-1-(3-pyridinyl)-1H-pyrazole-3-carboxylic acid; [show image] 1) Hydrogen bromide (12 ml, 47% aqueous solution) was slowly added to hydrogen bromide (12 ml, 47% aqueous solution) at 0 °C in a hydrobromic acid containing 2-amino-5-chloropyridine (5 g) ( 50 ml, 47%) solution. Subsequently, a solution of sodium nitrite (15 g) dissolved in water (20 ml) was added dropwise to the reaction mixture. The reaction solution was stirred at 0°C for 1 h. After that, a solution of sodium hydroxide (32 g) in water (80 ml) and ethyl acetate was added for extraction. The organic and aqueous phases were separated and the organic phase was dried over anhydrous sodium sulfate. After filtration, the solvent was removed by concentration under reduced pressure to give 2-bromo-5-chloropyridine (6.8 g, 91% yield) as a white solid. The product was characterized by 1H-NMR (400 MHz, CDCl3): δ 7.44 (1H, d, J = 8.42 Hz), 7.54 (1H, m), 8.36 (1H, s).
References
[1] Chemistry of Heterocyclic Compounds, 2017, vol. 53, # 2, p. 196 - 206
[2] Khim. Geterotsikl. Soedin., 2017, vol. 53, # 2, p. 196 - 206,11
[3] Patent: EP1698626, 2006, A1. Location in patent: Page/Page column 41
[4] Patent: EP1762568, 2007, A1. Location in patent: Page/Page column 24-25
[5] Patent: US5750545, 1998, A
2-Bromo-5-chloropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
2-Bromo-5-chloropyridine Suppliers
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View Lastest Price from 2-Bromo-5-chloropyridine manufacturers
- Product
- 2-Bromo-5-chloropyridine 40473-01-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-29
- Product
- 2-Bromo-5-chloropyridine 40473-01-6
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-30
- Product
- 2-Bromo-5-chloropyridine 40473-01-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-12