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MAFP

Product Name
MAFP
CAS No.
188404-10-6
Chemical Name
MAFP
Synonyms
MAPF;MAFP;Phosphonofluoridicacid;METHYL ARACHIDONYL FLUOROPHOSPHONATE;Methyl arachidonyl fluorophosphonate, 98%,;(5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraenylmethylester;METHYLPHOSPHONOFLUORIDIC ACID 5,8,11,14-EICOSATETRAENYL ESTER;5Z,8Z,11Z,14Z-EICOSATETRAENYL-PHOSPHONOFLUORIDIC ACID, METHYL ESTER;Phosphonofluoridic acid, methyl-5Z,8Z,11Z,14Z-eicosatetraenyl ester;(all-Z)-5,8,11,14-Eicosatetraenylphosphonofluoridic Acid Methyl Ester
CBNumber
CB9395022
Molecular Formula
C21H36FO2P
Formula Weight
370.48
MOL File
188404-10-6.mol
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MAFP Property

Boiling point:
455.3±34.0 °C(Predicted)
Density 
0.960±0.06 g/cm3(Predicted)
RTECS 
TA8108000
Flash point:
-16 °C
storage temp. 
-70°C
solubility 
DMF: 3 mg/ml; DMSO: 3 mg/ml; Ethanol: 3.5 mg/ml; Ethanol:PBS (pH 7.2) 1:1: .5 mg/ml; PBS (7.2): <1 mg/ml (colloidal suspension
form 
methyl acetate solution
color 
Light yellow to yellow
Sensitive 
Air Sensitive
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Safety

Hazard Codes 
F,Xi
Risk Statements 
11-36-66-67
Safety Statements 
16-26-29-33
RIDADR 
UN 1231 3/PG 2
WGK Germany 
1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

H336May cause drowsiness or dizziness

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M2939
Product name
Methyl arachidonyl fluorophosphonate
Purity
≥98%, methyl acetate solution (10 mg/mL)
Packaging
5MG
Price
$241
Updated
2023/06/20
Alfa Aesar
Product number
J67139
Product name
Methyl arachidonyl fluorophosphonate, 98%
Packaging
5mg
Price
$173
Updated
2021/12/16
Cayman Chemical
Product number
70660
Product name
Methyl Arachidonyl Fluorophosphonate
Purity
≥98%
Packaging
1mg
Price
$34
Updated
2024/03/01
Cayman Chemical
Product number
70660
Product name
Methyl Arachidonyl Fluorophosphonate
Purity
≥98%
Packaging
5mg
Price
$119
Updated
2024/03/01
Cayman Chemical
Product number
70660
Product name
Methyl Arachidonyl Fluorophosphonate
Purity
≥98%
Packaging
10mg
Price
$220
Updated
2024/03/01
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MAFP Chemical Properties,Usage,Production

Uses

(all-Z)-5,8,11,14-Eicosatetraenylphosphonofluoridic Acid Methyl Ester, is a cannabinoid CB1 receptor and fatty acid amide hydrolase inhibitors.

Definition

ChEBI: Methyl Arachidonyl Fluorophosphonate is a phosphonic ester.

Biological Activity

Potent, irreversible inhibitor of fatty acid amide hydrolase (FAAH, anandamide amidase), the enzyme responsible for anandamide hydrolysis (IC 50 = 2.5 nM). Also binds irreversibly to CB 1 receptors (IC 50 = 20 nM).

Biochem/physiol Actions

MAFP is a selective, irreversible inhibitor of both calcium-dependent and calcium-independent cytosolic phospholipase A2, but not secretory phospholipase A2. MAFP is also a potent acetylcholinesterase inhibitor.

MAFP Preparation Products And Raw materials

Raw materials

Preparation Products

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MAFP Suppliers

China 24 Germany 3 India 1 Japan 1 Switzerland 2 United Kingdom 2 United States 10 Global 43
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77
VWR International
Tel
--
Fax
--
Email
solutions@vwr.com
Country
United Kingdom
ProdList
6548
Advantage
82

188404-10-6, MAFPRelated Search:

Citicoline sodium U-73343 Phosphatidylinositol (Soy) SodiuM 2-Heptadecanone D609 PACOCF3 ARISTOLOCHIC ACID SODIUM SALT ISOTETRANDRINE 7,7-DIMETHYLEICOSADIENOIC ACID 2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID 7-hydroxycoumarinyl-γ-Linolenate MANOALIDE OLEYLOXYETHYL PHOSPHORYLCHOLINE BROMOENOL LACTONE Thioetheramide PC UMBELLIFERYL ARACHIDONATE LUFFARIELLOLIDE MAFP

  • 5Z,8Z,11Z,14Z-EICOSATETRAENYL-PHOSPHONOFLUORIDIC ACID, METHYL ESTER
  • (5Z,8Z,11Z,14Z)-5,8,11,14-EICOSATETRAENYL-METHYL ESTER PHOSPHONOFLUORIDIC ACID
  • MAFP
  • MAPF
  • METHYL-5Z,8Z,11Z,14Z-EICOSATETRAENYL ESTER PHOSPHONOFLUORIDIC ACID METHYL ACETATE
  • METHYL ARACHIDONYL FLUOROPHOSPHONATE
  • METHYLPHOSPHONOFLUORIDIC ACID 5,8,11,14-EICOSATETRAENYL ESTER
  • (5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraenylmethylester
  • Phosphonofluoridicacid
  • MAPF, Phosphonofluoridic acid, methyl-5Z,8Z,11Z,14Z-eicosatetraenyl ester
  • Phosphonofluoridic acid, methyl-5Z,8Z,11Z,14Z-eicosatetraenyl ester
  • (all-Z)-5,8,11,14-Eicosatetraenylphosphonofluoridic Acid Methyl Ester
  • (5Z,8Z,11Z,14Z)-1-[fluoro(methoxy)phosphoryl]icosa-5,8,11,14-tetraene
  • Phosphonofluoridic acid, P-(5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraen-1-yl-, methyl ester
  • Methyl arachidonyl fluorophosphonate, 98%,
  • Methyl Arachidonyl Fluorophosphonate, irreversible cPLA2 and iPLA2 inhibitor
  • 188404-10-6
  • C21H36FO2P
  • BioChemical
  • Biochemicals and Reagents
  • Phospholipase A 2
  • P to Q
  • Enzyme Inhibitors
  • Enzyme Inhibitors by Enzyme
  • Enzymes, Inhibitors, and Substrates
  • Cannabinoid receptor
  • Fatty Acid Derivatives & Lipids, inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals