(S)-1-Boc-3-(hyroxymethyl)piperidine

Product Name: (S)-1-Boc-3-(hyroxymethyl)piperidine
CAS No.: 140695-84-7
Chemical Name: (S)-1-Boc-3-(hyroxymethyl)piperidine
Synonyms: tert-butyl (S)-3-(hydroxymethyl)piperidine-1-carboxylate;(S)-N-Boc-3-piperidinemethanol;(S)-TERT-BUTYL 3-(HYDROXYMETHYL)PIPERIDINE-1-CARBOXYLATE;CAS:140695-84-7;N-BOC-(3S)-PIP(3-CH2OH);(S)-1-Boc-3-(hydroxymethyL;3-(S)-N-BOC-PIPERIDINE METHANOL;(S)-N-Boc-piperdine-3-hydroxymethyl;(S)-N-Boc-3-(hyroxymethyl)piperidine;(S)-1-BOC-3-(HYROXYMETHYL)PIPERIDINE
CBNumber: CB9407028
Molecular Formula: C11H21NO3
Formula Weight: 215.29
MOL File: 140695-84-7.mol

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(S)-1-Boc-3-(hyroxymethyl)piperidine Property

Melting point:: 96-98 °C
Boiling point:: 308.0±15.0 °C(Predicted)
Density: 1.059±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 14.93±0.10(Predicted)
form: Powder
color: White
Water Solubility: Slightly soluble in water.
InChI: InChI=1S/C11H21NO3/c1-11(2,3)15-10(14)12-6-4-5-9(7-12)8-13/h9,13H,4-8H2,1-3H3/t9-/m0/s1
InChIKey: OJCLHERKFHHUTB-VIFPVBQESA-N
SMILES: N1(C(OC(C)(C)C)=O)CCC[C@H](CO)C1
CAS DataBase Reference: 140695-84-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: B656623
Product name: (S)-1-BOC-3-(Hydroxymethyl)piperidine
Packaging: 100mg
Price: $75
Updated: 2021/12/16

AK Scientific

Product number: U440
Product name: (S)-1-Boc-3-(hydroxymethyl)piperidine
Packaging: 5g
Price: $90
Updated: 2021/12/16

Apolloscientific

Product number: OR15674
Product name: (3S)-3-(Hydroxymethyl)piperidine,N-BOCprotected
Packaging: 25g
Price: $173
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H29-1-X9
Product name: (3S)-3-(Hydroxymethyl)piperidine, N-Boc protected
Packaging: 25g
Price: $191
Updated: 2021/12/16

Matrix Scientific

Product number: 073565
Product name: (S)-1-Boc-3-(Hydroxymethyl)piperidine
Purity: 95+%
Packaging: 5g
Price: $200
Updated: 2021/12/16

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(S)-1-Boc-3-(hyroxymethyl)piperidine Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

(S)-1-Boc-3-(hydroxymethyl)piperidine is used as pharmaceutical intermediate.

Synthesis

163438-09-3

116574-71-1

The general procedure for the synthesis of tert-butyl 3-(hydroxymethyl)piperidine-1-carboxylate from (R)-1-(tert-butoxycarbonyl)piperidine-3-carboxylate is as follows: Example 58: Synthesis of N-(2-methylpropyl)-N-(3,5-dichlorophenylmethyl)-(3R)-piperidin-3-ylmethylamine 1.5L-tartrate: (i) Borane-tetrahydrofuran complex (1M solution of THF, 65.4 ml, 65.4 mmol, 3 eq.) was slowly added dropwise to a solution of (R)-N-Boc-piperidine-3-carboxylic acid (5 g, 21.8 mmol, 1 eq.) in THF (50 ml) at room temperature. The reaction mixture was stirred at room temperature for 16 hours. Subsequently, the solution was cooled to 0°C and hydrolyzed by careful addition of 2N aqueous sodium hydroxide solution (250 ml). The hydrolyzed mixture was heated and refluxed for 48 hours. After completion of the reaction, the mixture was again cooled to 0°C and extracted with ether (3 x 100 ml). The organic layers were combined, washed with brine (100 ml), dried over magnesium sulfate, filtered and concentrated in vacuum. The residue was purified by fast chromatography using isohexane solution of 50-70% ethyl acetate as eluent to give the title compound tert-butyl (3R)-3-(hydroxymethyl)piperidine-1-carboxylate (4.56 g, 98% yield). 1H NMR (300 MHz, CDCl3) δ: 4.0-2.7 (6H, br m), 2.17-1.19 (5H, br m), 1.46 (9H, s).

References

[1] Patent: WO2005/118531, 2005, A1. Location in patent: Page/Page column 74
[2] Patent: WO2006/12308, 2006, A1. Location in patent: Page/Page column 68
[3] Patent: WO2017/103611, 2017, A1. Location in patent: Paragraph 00298

(S)-1-Boc-3-(hyroxymethyl)piperidine Preparation Products And Raw materials

Raw materials

Ethanol D-(-)-Tartaric Acid Sodium chloride Di-tert-butyl dicarbonate Sodium borohydride Tetrahydrofuran Diethyl ether Ammonium chloride Lithium Aluminum Hydride Dichloromethane Ethyl nipecotate Sodium hydroxide L(+)-Tartaric acid Magnesium sulfate

Preparation Products

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(S)-1-Boc-3-(hyroxymethyl)piperidine Suppliers

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View Lastest Price from (S)-1-Boc-3-(hyroxymethyl)piperidine manufacturers

Career Henan Chemical Co

Product: (S)-1-Boc-3-(hyroxymethyl)piperidine 140695-84-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 150KG
Release date: 2019-07-09

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140695-84-7