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Doxylamine succinate

Product Name
Doxylamine succinate
CAS No.
562-10-7
Chemical Name
Doxylamine succinate
Synonyms
unisom;decapryn;hoggarn;alsadorm;gittalun;sedaplus;mereprine;DoxylaMineSuccinat;Decapryn succinate;DOXYLAMINE SUCCINATE
CBNumber
CB9416701
Molecular Formula
C21H28N2O5
Formula Weight
388.46
MOL File
562-10-7.mol
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Doxylamine succinate Property

Melting point:
95-98?C
Flash point:
9℃
storage temp. 
2-8°C
solubility 
Very soluble in water, freely soluble in ethanol (96 per cent).
form 
Solid
color 
White to Off-White
Stability:
Stable, but may be light sensitive. Incompatible with strong oxidizing agents, acids, bases.
InChIKey
KBAUFVUYFNWQFM-UHFFFAOYSA-N
LogP
2.519 (est)
CAS DataBase Reference
562-10-7(CAS DataBase Reference)
IARC
3 (Vol. 79) 2001
EPA Substance Registry System
Doxylamine succinate (1:1) (562-10-7)
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Safety

Hazard Codes 
Xn,T,F
Risk Statements 
22-36/37/38-20/21/22-39/23/24/25-23/24/25-11
Safety Statements 
26-36/37-45-16-7
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
2
RTECS 
US9275000
HS Code 
2933399090
Toxicity
LD50 in mice, rabbits (mg/kg): 470, 250 orally; 62, 49 i.v.; in mice, male rats, female rats (mg/kg): 460, 440, 445 s.c. (Brown, Werner)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D-045
Product name
Doxylamine succinate solution
Purity
1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant?
Packaging
1mL
Price
$50
Updated
2024/03/01
Sigma-Aldrich
Product number
1227006
Product name
Doxylamine succinate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
300mg
Price
$436
Updated
2024/03/01
TCI Chemical
Product number
D5583
Product name
Doxylamine Succinate
Packaging
5G
Price
$32
Updated
2024/03/01
TCI Chemical
Product number
D5583
Product name
Doxylamine Succinate
Packaging
25G
Price
$96
Updated
2024/03/01
Cayman Chemical
Product number
21826
Product name
Doxylamine (succinate)
Purity
≥98%
Packaging
1mg
Price
$41
Updated
2024/03/01
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Doxylamine succinate Chemical Properties,Usage,Production

Chemical Properties

white to light cream powder

Uses

antihistaminic, hypnotic

Uses

Doxylamine succinate salt has been used as a therapeutic drug to check developmental toxicity.

Uses

H1 Histamine receptor antagonist. Antihistaminic; sedative; hypnotic.

Definition

ChEBI: Doxylamine succinate is an organic molecular entity.

brand name

Decapryn (Sanofi Aventis); Unisom (Pfizer).

General Description

The acid succinate salt (bisuccinate)of doxylamine, 2-[ -[2-(dimethylamino)ethoxy]- -methylbenzyl]pyridine bisuccinate (Decapryn Succinate), isa white to creamy-white powder with a characteristic odor.It is soluble in water (1:1), alcohol (1:2), and chloroform(1:2). A 1% solution has a pH of about 5.Doxylamine succinate is comparable in potency todiphenhydramine. It is indicated for the relief of seasonalrhinitis symptoms, but is also used as a nighttime sedative.Concurrent use of alcohol and other CNS depressantsshould be avoided.

General Description

White or creamy white powder. pH (1% aqueous solution) between 4.9 and 5.1.

Air & Water Reactions

Water soluble.

Health Hazard

SYMPTOMS: Symptoms of exposure to Doxylamine succinate may include drowsiness, excitability, nervousness, dizziness and sleeplessness.

Fire Hazard

Flash point data for Doxylamine succinate are not available. Doxylamine succinate is probably combustible.

Biochem/physiol Actions

H1 histamine receptor antagonist; hypnotic.Doxylamine suppresses histamine at the H1 receptor. It is associated with the short term management of insomnia and temporary relief of common cold symptoms. On the other hand, doxylamine intoxication is linked with rhabdomyolysis and secondary acute renal failure.Studies in mice show that doxylamine induces liver microsomal cytochrome P450 and other enzymes involved in thyroxine (T4) metabolism. In combination with pyridoxine hydrochloride, this drug is used to treat morning sickness.

Doxylamine succinate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Doxylamine succinate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Doxylamine succinate 562-10-7
Price
US $0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
500kg/month
Release date
2021-07-23
Baoji Guokang Bio-Technology Co., Ltd.
Product
Doxylamine succinate 562-10-7
Price
US $483.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000Kg
Release date
2021-06-03
Hebei Yanxi Chemical Co., Ltd.
Product
Doxylamine succinate 562-10-7
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20tons
Release date
2023-10-08

562-10-7, Doxylamine succinateRelated Search:

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  • Butanedioic acid, compd. withN,N-dimethyl-2-[1-phenyl-1-(2-pyridinyl)ethoxy]ethanamine (1:1)OTHER CA INDEX NAMES:Ethanamine, N,N-dimethyl-2-[1-phenyl-1-(2-pyridinyl)ethoxy]-,butanedioate (1:1)
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