ChemicalBook > CAS DataBase List > Doxylamine succinate
Doxylamine succinate
- Product Name
- Doxylamine succinate
- CAS No.
- 562-10-7
- Chemical Name
- Doxylamine succinate
- Synonyms
- unisom;decapryn;hoggarn;alsadorm;gittalun;sedaplus;mereprine;DoxylaMineSuccinat;Decapryn succinate;DOXYLAMINE SUCCINATE
- CBNumber
- CB9416701
- Molecular Formula
- C21H28N2O5
- Formula Weight
- 388.46
- MOL File
- 562-10-7.mol
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Doxylamine succinate Property
- Melting point:
- 95-98?C
- Flash point:
- 9℃
- storage temp.
- 2-8°C
- solubility
- Very soluble in water, freely soluble in ethanol (96 per cent).
- color
- White to Off-White
- Stability:
- Stable, but may be light sensitive. Incompatible with strong oxidizing agents, acids, bases.
- InChIKey
- KBAUFVUYFNWQFM-UHFFFAOYSA-N
- LogP
- 2.519 (est)
- CAS DataBase Reference
- 562-10-7(CAS DataBase Reference)
- IARC
- 3 (Vol. 79) 2001
- EPA Substance Registry System
- Doxylamine succinate (1:1) (562-10-7)
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Safety
- Hazard Codes
- Xn,T,F
- Risk Statements
- 22-36/37/38-20/21/22-39/23/24/25-23/24/25-11
- Safety Statements
- 26-36/37-45-16-7
- RIDADR
- UN1230 - class 3 - PG 2 - Methanol, solution
- WGK Germany
- 2
- RTECS
- US9275000
- HS Code
- 2933399090
- Toxicity
- LD50 in mice, rabbits (mg/kg): 470, 250 orally; 62, 49 i.v.; in mice, male rats, female rats (mg/kg): 460, 440, 445 s.c. (Brown, Werner)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- D-045
- Product name
- Doxylamine succinate solution
- Purity
- 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant?
- Packaging
- 1mL
- Price
- $50
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- 1227006
- Product name
- Doxylamine succinate
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 300mg
- Price
- $436
- Updated
- 2024/03/01
TCI Chemical
- Product number
- D5583
- Product name
- Doxylamine Succinate
- Packaging
- 5G
- Price
- $32
- Updated
- 2024/03/01
TCI Chemical
- Product number
- D5583
- Product name
- Doxylamine Succinate
- Packaging
- 25G
- Price
- $96
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 21826
- Product name
- Doxylamine (succinate)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $41
- Updated
- 2024/03/01
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Doxylamine succinate Chemical Properties,Usage,Production
Chemical Properties
white to light cream powder
Uses
antihistaminic, hypnotic
Uses
Doxylamine succinate salt has been used as a therapeutic drug to check developmental toxicity.
Uses
H1 Histamine receptor antagonist. Antihistaminic; sedative; hypnotic.
Definition
ChEBI: Doxylamine succinate is an organic molecular entity.
brand name
Decapryn (Sanofi Aventis); Unisom (Pfizer).
General Description
The acid succinate salt (bisuccinate)of doxylamine, 2-[ -[2-(dimethylamino)ethoxy]- -methylbenzyl]pyridine bisuccinate (Decapryn Succinate), isa white to creamy-white powder with a characteristic odor.It is soluble in water (1:1), alcohol (1:2), and chloroform(1:2). A 1% solution has a pH of about 5.Doxylamine succinate is comparable in potency todiphenhydramine. It is indicated for the relief of seasonalrhinitis symptoms, but is also used as a nighttime sedative.Concurrent use of alcohol and other CNS depressantsshould be avoided.
General Description
White or creamy white powder. pH (1% aqueous solution) between 4.9 and 5.1.
Air & Water Reactions
Water soluble.
Health Hazard
SYMPTOMS: Symptoms of exposure to Doxylamine succinate may include drowsiness, excitability, nervousness, dizziness and sleeplessness.
Fire Hazard
Flash point data for Doxylamine succinate are not available. Doxylamine succinate is probably combustible.
Biochem/physiol Actions
H1 histamine receptor antagonist; hypnotic.Doxylamine suppresses histamine at the H1 receptor. It is associated with the short term management of insomnia and temporary relief of common cold symptoms. On the other hand, doxylamine intoxication is linked with rhabdomyolysis and secondary acute renal failure.Studies in mice show that doxylamine induces liver microsomal cytochrome P450 and other enzymes involved in thyroxine (T4) metabolism. In combination with pyridoxine hydrochloride, this drug is used to treat morning sickness.
Doxylamine succinate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Doxylamine succinate manufacturers
Hebei Kangcang new material Technology Co., LTD
- Product
- DOXYLAMINE SUCCINATE 562-10-7
- Price
- US $20.00-10.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 20
- Release date
- 2024-03-28
Shaanxi Dideu Medichem Co. Ltd
- Product
- Doxylamine succinate 562-10-7
- Price
- US $1.00-1.00/KG
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 50tons
- Release date
- 2020-05-08
Hebei Yanxi Chemical Co., Ltd.
- Product
- Doxylamine succinate 562-10-7
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-10-08
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