Doxylamine succinate

Product Name: Doxylamine succinate
CAS No.: 562-10-7
Chemical Name: Doxylamine succinate
Synonyms: unisom;decapryn;hoggarn;alsadorm;gittalun;sedaplus;mereprine;DoxylaMineSuccinat;Decapryn succinate;DOXYLAMINE SUCCINATE
CBNumber: CB9416701
Molecular Formula: C21H28N2O5
Formula Weight: 388.46
MOL File: 562-10-7.mol

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Doxylamine succinate Property

Melting point:: 95-98?C
Flash point:: 9℃
storage temp.: 2-8°C
solubility: Very soluble in water, freely soluble in ethanol (96 per cent).
form: Solid
color: White to Off-White
Stability:: Stable, but may be light sensitive. Incompatible with strong oxidizing agents, acids, bases.
InChIKey: KBAUFVUYFNWQFM-UHFFFAOYSA-N
LogP: 2.519 (est)
CAS DataBase Reference: 562-10-7(CAS DataBase Reference)
IARC: 3 (Vol. 79) 2001
EPA Substance Registry System: Doxylamine succinate (1:1) (562-10-7)

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Safety

Hazard Codes: Xn,T,F
Risk Statements: 22-36/37/38-20/21/22-39/23/24/25-23/24/25-11
Safety Statements: 26-36/37-45-16-7
RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany: 2
RTECS: US9275000
HS Code: 2933399090
Toxicity: LD50 in mice, rabbits (mg/kg): 470, 250 orally; 62, 49 i.v.; in mice, male rats, female rats (mg/kg): 460, 440, 445 s.c. (Brown, Werner)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D-045
Product name: Doxylamine succinate solution
Purity: 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant?
Packaging: 1mL
Price: $50
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1227006
Product name: Doxylamine succinate
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 300mg
Price: $436
Updated: 2024/03/01

TCI Chemical

Product number: D5583
Product name: Doxylamine Succinate
Packaging: 5G
Price: $32
Updated: 2024/03/01

TCI Chemical

Product number: D5583
Product name: Doxylamine Succinate
Packaging: 25G
Price: $96
Updated: 2024/03/01

Cayman Chemical

Product number: 21826
Product name: Doxylamine (succinate)
Purity: ≥98%
Packaging: 1mg
Price: $41
Updated: 2024/03/01

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Doxylamine succinate Chemical Properties,Usage,Production

Chemical Properties

white to light cream powder

Uses

antihistaminic, hypnotic

Uses

Doxylamine succinate salt has been used as a therapeutic drug to check developmental toxicity.

Uses

H1 Histamine receptor antagonist. Antihistaminic; sedative; hypnotic.

Definition

ChEBI: Doxylamine succinate is an organic molecular entity.

brand name

Decapryn (Sanofi Aventis); Unisom (Pfizer).

General Description

The acid succinate salt (bisuccinate)of doxylamine, 2-[ -[2-(dimethylamino)ethoxy]- -methylbenzyl]pyridine bisuccinate (Decapryn Succinate), isa white to creamy-white powder with a characteristic odor.It is soluble in water (1:1), alcohol (1:2), and chloroform(1:2). A 1% solution has a pH of about 5.Doxylamine succinate is comparable in potency todiphenhydramine. It is indicated for the relief of seasonalrhinitis symptoms, but is also used as a nighttime sedative.Concurrent use of alcohol and other CNS depressantsshould be avoided.

General Description

White or creamy white powder. pH (1% aqueous solution) between 4.9 and 5.1.

Air & Water Reactions

Water soluble.

Health Hazard

SYMPTOMS: Symptoms of exposure to Doxylamine succinate may include drowsiness, excitability, nervousness, dizziness and sleeplessness.

Fire Hazard

Flash point data for Doxylamine succinate are not available. Doxylamine succinate is probably combustible.

Biochem/physiol Actions

H1 histamine receptor antagonist; hypnotic.Doxylamine suppresses histamine at the H1 receptor. It is associated with the short term management of insomnia and temporary relief of common cold symptoms. On the other hand, doxylamine intoxication is linked with rhabdomyolysis and secondary acute renal failure.Studies in mice show that doxylamine induces liver microsomal cytochrome P450 and other enzymes involved in thyroxine (T4) metabolism. In combination with pyridoxine hydrochloride, this drug is used to treat morning sickness.

Doxylamine succinate Preparation Products And Raw materials

Raw materials

Preparation Products

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Doxylamine succinate Suppliers

Americas 1 Belgium 1 Canada 4 China 177 Europe 3 Finland 1 France 1 Germany 9 India 91 Italy 2 Japan 1 Poland 1 Singapore 1 Spain 2 Switzerland 1 The Netherlands 1 United Kingdom 6 United States 39 Venezuela 1 Global 343

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44689
Advantage: 61

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2123
Advantage: 70

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9815
Advantage: 79

Spectrum Chemical Manufacturing Corp.

Tel: 021-021-021-67601398-809-809-809 15221380277
Fax: 021-57711696
Email: marketing_china@spectrumchemical.com
Country: China
ProdList: 9658
Advantage: 60

Wuhan Fortuna Chemical Co., Ltd

Tel: 027-59207852 13308628970
Fax: QQ3130921841
Email: buy@fortunachem.com
Country: China
ProdList: 2871
Advantage: 58

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12335
Advantage: 58

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

TOKYO CHEMICAL INDUSTRY CO., LTD.

Tel: 03-36680489
Fax: 03-3668-0520
Email: Sales-JP@TCIchemicals.com
Country: Japan
ProdList: 28387
Advantage: 80

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View Lastest Price from Doxylamine succinate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Doxylamine succinate 562-10-7
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 500kg/month
Release date: 2021-07-23

Baoji Guokang Bio-Technology Co., Ltd.

Product: Doxylamine succinate 562-10-7
Price: US $483.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000Kg
Release date: 2021-06-03

Hebei Yanxi Chemical Co., Ltd.

Product: Doxylamine succinate 562-10-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-10-08

562-10-7, Doxylamine succinateRelated Search:

Metroprolol succinate DOXYLAMINE Dimethyl sulfate iron succinate Dimethyl carbonate Dimethyl ether Succinic acid Dimethyl fumarate Chlorodimethylphenylsilane ETHANE Disodium succinate Dimethyl sulfoxide Ethoxyquin 6alpha-Methylprednisolone sodium succinate Dimethyl sulfide N,N-Dimethylformamide 1-PYRIDIN-2-YL-ETHANOL 1-PHENYL-1-(2-PYRIDYL)ETHANOL

LABOTEST-BB LT00244822

DOXYLAMINE SUCCINATE

DOXYLAMINE SUCCINATE SALT

2-(alpha-(2-(dimethylamino)ethoxy)-alpha-methylbenzyl)-pyridinsuccinate(1

2-(alpha-(2-dimethylaminoethoxy)-alpha-methylbenzyl)pyridinesuccinate

2-dimethylaminoethoxyphenylmethyl-2-picolinesuccinate

alsadorm

decapryn

decarpynsuccinate(1:1)

dimethylaminoethoxy-methyl-benzyl-pyridinesuccinate

DoxylaMineSuccinat

Doxylamine Succinate (300 mg)

Decapryn succinate

DOXYLAMINESUCCINATE,USP

N,N-dimethyl-2-(1-phenyl-1-pyridin-2-yl-ethoxy)ethanamine

Doxylaminhydrogensuccinat

N,N-Dimethyl-2-[1-phenyl-1-(2-pyridinyl)ethoxy]ethanamine succinate

DOXLAMINE SUCCINATE USP

[(3-carboxypropanoyl)oxy]diMethyl{2-[1-phenyl-1-(pyridin-2-yl)ethoxy]ethyl}aMinyl

Butanedioic acid, compd. with N,N-dimethyl-2-[1-phenyl-1-(2-pyridinyl)ethoxy]ethanamine (1:1)

Doxylamine for system suitability

Doxylamine succinate solution

doxylaminesuccinate(1:1)

gittalun

hoggarn

mereprine

phenyl2-pyridylmethyl-beta-n,n-dimethylaminoethylethersuccinate

sedaplus

unisom

N,N-DIMETHYL-2-[1-PHENYL-1-(2-PYRIDINYL)ETHOXY]ETHENAMINE SUCCINATE

Doxylamine hydrogen succinate CRS

Doxylamine for system suitability CRS

Doxylaminesuccinatesal

N,N-Dimethyl-2-[1-phenyl-1-(pyridin-2-yl)ethoxy]ethanamine Succinate

Doxylamine succinate USP/EP/BP

doxl amine succinate

Doxylamine succinateQ: What is Doxylamine succinate Q: What is the CAS Number of Doxylamine succinate Q: What is the storage condition of Doxylamine succinate Q: What are the applications of Doxylamine succinate

Doxylamine Succinate (1227006)

Docylamine succinate

N,N-dimethyl-2-(1-phenyl-1-pyridin-2-ylethoxy)ethanamine (Doxylamine succinate)

Butanedioic acid, compd. withN,N-dimethyl-2-[1-phenyl-1-(2-pyridinyl)ethoxy]ethanamine (1:1)OTHER CA INDEX NAMES:Ethanamine, N,N-dimethyl-2-[1-phenyl-1-(2-pyridinyl)ethoxy]-,butanedioate (1:1)

Doxylamine succinate in methanol

562-10-7

C17H22N2OC4H6O4

API

DECAPRYN

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Histaminergics

Neurotransmitters

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