Pinacidil
- Product Name
- Pinacidil
- CAS No.
- 85371-64-8
- Chemical Name
- Pinacidil
- Synonyms
- Hndac;Pinacidil;Pinacidil Hydrate;Pinacidil USP/EP/BP;Pinacidil monohydrate (Pinacidil hydrate);Pinacidil monohydrate (Synonyms: Pinacidil hydrate);(+/-)-N-Cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)guanidine;Guanidine, N-cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)-, monohydrate;(±)-N-Cyano-N’-4-pyridinyl-N’’-(1，2，2-trimethylpropyl)guanidine monohydrate;Guanidine,N-cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)-, hydrate (1:1)
- CBNumber
- CB9498330
- Molecular Formula
- C13H21N5O
- Formula Weight
- 263.35
- MOL File
- 85371-64-8.mol
Pinacidil Property
- Melting point:
- 164-165°
- storage temp.
- RT
- solubility
- ethanol: 14 mg/mL
- form
- solid
- pka
- pKa 空 (Uncertain)
- color
- white
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
- CAS DataBase Reference
- 85371-64-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 36
- WGK Germany
- 3
- Toxicity
- LD50 in mice, rats (mg/kg): 600, 570 orally (Petersen, 1978)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P154
- Product name
- Pinacidil monohydrate
- Purity
- powder
- Packaging
- 100mg
- Price
- $152
- Updated
- 2024/03/01
- Product number
- P154
- Product name
- Pinacidil monohydrate
- Purity
- powder
- Packaging
- 1g
- Price
- $901
- Updated
- 2024/03/01
- Product number
- 15416
- Product name
- Pinacidil (hydrate)
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $29
- Updated
- 2024/03/01
- Product number
- 15416
- Product name
- Pinacidil (hydrate)
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $54
- Updated
- 2024/03/01
- Product number
- P154
- Product name
- Pinacidil monohydrate
- Purity
- powder
- Packaging
- 500mg
- Price
- $603
- Updated
- 2024/03/01
Pinacidil Chemical Properties,Usage,Production
Description
Pinacidil is a peripheral vasodilator useful in the management of arterial hypertension of all degrees of seventy, usually in combination with a diuretic or beta-blocker. Preclinical evidence suggests that its hypotensive effect may be attributed to potassium channel activation.
Originator
Leo (Denmark)
Uses
Pinacidil Monohydrate is a K+ channel opener, used to induce relaxation of serotonin-produced contractions in porcine and human arterial rings. Vasodilator. Antihypertensive agent.
Uses
Pinacidil monohydrate has been used:
- in repolarization studies by infusing into left anterior descending artery (LAD)
- to induce ATP-sensitive K+ (KATP) current in ventricular myocytes for electrophysiological studies
- as a KATP opener to treat myocardial cells
Uses
cardiac stimulant
Definition
ChEBI: Pinacidil is an organic molecular entity.
brand name
Pindac (Leo).
Biochem/physiol Actions
Pinacidil is a KATP channel agonist. It protects cardiomyocytes by preventing loss of mitochondrial membrane potential. It prevents the caspase 3 activation in hypoxia/reoxygenation injury.
References
1) Hermsmeyer et al. (1988), Pinacidil actions on ion channels in vascular muscle; J. Cardiovasc. Pharmacol., 12(Suppl. 2) S17 2) Gollasch et al. (1995), Pinacidil relaxes porcine and human coronary arteries by activating ATP-dependent potassium channels in smooth muscle cells; J. Pharmacol. Exp. Therap., 275 681 3) Cohen & Kurz (1988), Pinacidil-induced vascular relaxation: comparison to other vasodilators and to classical mechanisms of vasodilation; J. Cardiovasc. Pharmacol., 12(Suppl. 2) S5 4) Teshima et al. (2003), Mitochondrial ATP-sensitive potassium channel activation protects cerebellar granule neurons from apoptosis induced by oxidative stress; Stroke, 34 1796 5) Xie et al. (2010), K(ATP) channel openers protect mesencephalic neurons against MPP+-induced cytotoxicity via inhibition of ROS protection; J. Neurosci. Res., 88 428 6) Zhang et al. (2008), Effects of ATP sensitive potassium channel opener on the mRNA and protein expressions of caspase-12 after cerebral ischemia-reperfusion in rats; Neurosci. Bull., 24 7
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Raw materials
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View Lastest Price from Pinacidil manufacturers
- Product
- Pinacidil monohydrate 85371-64-8
- Price
- US $1.90/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 ton
- Release date
- 2024-08-15
- Product
- Pinacidil 85371-64-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 500 MT
- Release date
- 2020-05-11
- Product
- Pinacidil 85371-64-8
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 95%-99%
- Supply Ability
- 10kg
- Release date
- 2018-12-18