ChemicalBook > CAS DataBase List > Pinacidil

Pinacidil

Product Name: Pinacidil
CAS No.: 85371-64-8
Chemical Name: Pinacidil
Synonyms: Hndac;Pinacidil;Pinacidil Hydrate;Pinacidil USP/EP/BP;Pinacidil monohydrate, 10 mM in DMSO;Pinacidil monohydrate (Pinacidil hydrate);Pinacidil monohydrate (Synonyms: Pinacidil hydrate);(+/-)-N-Cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)guanidine;N-Cyano-N′-4-pyridinyl-N′′-(1,2,2-trimethylpropyl)guanidine monohydrate;Guanidine, N-cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)-, monohydrate
CBNumber: CB9498330
Molecular Formula: C13H21N5O
Formula Weight: 263.35
MOL File: 85371-64-8.mol

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Pinacidil Property

Melting point:: 164-165°
storage temp.: RT
solubility: ethanol: 14 mg/mL
form: solid
pka: pKa (Uncertain)
color: white
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
CAS DataBase Reference: 85371-64-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 36
WGK Germany: 3
Toxicity: LD50 in mice, rats (mg/kg): 600, 570 orally (Petersen, 1978)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P154
Product name: Pinacidil monohydrate
Purity: powder
Packaging: 100mg
Price: $164
Updated: 2025/07/31

Sigma-Aldrich

Product number: P154
Product name: Pinacidil monohydrate
Purity: powder
Packaging: 1g
Price: $926
Updated: 2025/07/31

Cayman Chemical

Product number: 15416
Product name: Pinacidil (hydrate)
Purity: ≥98%
Packaging: 25mg
Price: $29
Updated: 2024/03/01

Cayman Chemical

Product number: 15416
Product name: Pinacidil (hydrate)
Purity: ≥98%
Packaging: 50mg
Price: $54
Updated: 2024/03/01

Sigma-Aldrich

Product number: P154
Product name: Pinacidil monohydrate
Purity: powder
Packaging: 500mg
Price: $434
Updated: 2025/07/31

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Pinacidil Chemical Properties,Usage,Production

Description

Pinacidil is a peripheral vasodilator useful in the management of arterial hypertension of all degrees of seventy, usually in combination with a diuretic or beta-blocker. Preclinical evidence suggests that its hypotensive effect may be attributed to potassium channel activation.

Chemical Properties

Crystalline, melting point 164-165°C. Acute toxicity LD50 mice, rats (mg/kg): 600, 570 oral.

Originator

Leo (Denmark)

Uses

Pinacidil Monohydrate is a K+ channel opener, used to induce relaxation of serotonin-produced contractions in porcine and human arterial rings. Vasodilator. Antihypertensive agent.

Uses

Pinacidil monohydrate has been used:

in repolarization studies by infusing into left anterior descending artery (LAD)
to induce ATP-sensitive K⁺ (K_ATP) current in ventricular myocytes for electrophysiological studies
as a KATP opener to treat myocardial cells

Uses

cardiac stimulant

Definition

ChEBI: Pinacidil is an organic molecular entity.

brand name

Pindac (Leo).

Biochem/physiol Actions

Pinacidil is a KATP channel agonist. It protects cardiomyocytes by preventing loss of mitochondrial membrane potential. It prevents the caspase 3 activation in hypoxia/reoxygenation injury.

References

[1] HERMSMEYER R K. Pinacidil actions on ion channels in vascular muscle.[J]. Journal of Cardiovascular Pharmacology, 1988, 12 Suppl 2: S17-22. DOI:10.1097/00005344-198812002-00005
[2] M GOLLASCH. Pinacidil relaxes porcine and human coronary arteries by activating ATP-dependent potassium channels in smooth muscle cells.[J]. Journal of Pharmacology and Experimental Therapeutics, 1995, 275 2: 681-692.
[3] M. COHEN K K. Pinacidil-induced vascular relaxation: comparison to other vasodilators and to classical mechanisms of vasodilation.[J]. Journal of Cardiovascular Pharmacology, 1988, 12 Suppl 2 1: S5-9. DOI:10.1097/00005344-198812002-00003
[4] YASUSHI TESHIMA. Mitochondrial ATP-sensitive potassium channel activation protects cerebellar granule neurons from apoptosis induced by oxidative stress.[J]. Stroke, 2003, 34 7: 1796-1802. DOI:10.1161/01.str.0000077017.60947.ae
[5] K(ATP) channel openers protect mesencephalic neurons against MPP+-induced cytotoxicity via inhibition of ROS protection
[6] HONG ZHANG. Effects of ATP sensitive potassium channel opener on the mRNA and protein expressions of caspase-12 after cerebral ischemia-reperfusion in rats.[J]. Neuroscience bulletin, 2008, 24 1: 7-12. DOI:10.1007/s12264-008-1227-7

Pinacidil Preparation Products And Raw materials

Raw materials

Diisopropylamine

Preparation Products

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View Lastest Price from Pinacidil manufacturers

Hebei Chuanghai Biotechnology Co,.LTD

Product: Pinacidil monohydrate 85371-64-8
Price: US $1.90/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 ton
Release date: 2024-08-15

Shaanxi Dideu Medichem Co. Ltd

Product: Pinacidil 85371-64-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 500 MT
Release date: 2020-05-11

Career Henan Chemical Co

Product: Pinacidil 85371-64-8
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: 10kg
Release date: 2018-12-18

85371-64-8, PinacidilRelated Search:

POLYAMINOPROPYL BIGUANIDE Buflomedil hydrochloride Azamethiphos Chloromethyl isopropyl carbonate Diltiazem Prostaglandin E1 2,4,6-Collidine 6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil Dicyandiamide Methyl propyl carbonate 2,6-Lutidine GUANIDINE Guanidine nitrate pirozadil PINACIDIL 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine PIRIBEDIL HYDROCHLORIDE pinacidil pyridine N-oxide,Pinacidil N-oxide

Pinacidil monohydrate (Synonyms: Pinacidil hydrate)

Pinacidil monohydrate (Pinacidil hydrate)

(+/-)-N-Cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)guanidine

Pinacidil

Hndac

(±)-N-Cyano-N’-4-pyridinyl-N’’-(1，2，2-trimethylpropyl)guanidine monohydrate

Guanidine, N-cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)-, monohydrate

Pinacidil Hydrate

Guanidine,N-cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)-, hydrate (1:1)

Pinacidil USP/EP/BP

P1134,P-1134,Pinacidil monohydrate,inhibit,P 1134,Inhibitor,Potassium Channel,Pinacidil,KcsA

Pinacidil monohydrate, 10 mM in DMSO

N-Cyano-N′-4-pyridinyl-N′′-(1,2,2-trimethylpropyl)guanidine monohydrate

85371-64-8

85371-64-6

C13H19N5H2O

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