ChemicalBook > CAS DataBase List > AC-YVAD-PNA

AC-YVAD-PNA

Product Name
AC-YVAD-PNA
CAS No.
149231-66-3
Chemical Name
AC-YVAD-PNA
Synonyms
AC-YVAD-PNA;ACETYL-YVAD-PNA;ICE SUBSTRATE IV;AC-TYR-VAL-ALA-ASP-PNA;Caspase-1 Substrate IV;REF DUPL: Ac-Tyr-Val-Ala-Asp-pNA;CASPASE-1 SUBSTRATE (CHROMOGENIC);AC-TYR-VAL-ALA-ASP-PNA: AC-YVAD-PNA;AC-TYR-VAL-ALA-ASP-PARANITROANILIDE;IL-1B CONVERTING ENZYME SUBSTRATE IV
CBNumber
CB9669912
Molecular Formula
C29H36N6O10
Formula Weight
628.63
MOL File
149231-66-3.mol
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AC-YVAD-PNA Property

Boiling point:
1108.9±65.0 °C(Predicted)
Density 
1.362±0.06 g/cm3(Predicted)
storage temp. 
-15°C
pka
4.04±0.10(Predicted)
form 
powder
color 
white to beige
Sequence
Ac-Tyr-Val-Ala-Asp-{pNA}
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1424
Product name
Ac-YVAD-pNA
Purity
≥98% (HPLC)
Packaging
5mg
Price
$103
Updated
2025/07/31
Sigma-Aldrich
Product number
SML1424
Product name
Ac-YVAD-pNA
Purity
≥98% (HPLC)
Packaging
25mg
Price
$414
Updated
2025/07/31
Cayman Chemical
Product number
17487
Product name
Ac-YVAD-pNA
Purity
≥95%
Packaging
5mg
Price
$69
Updated
2021/12/16
Cayman Chemical
Product number
17487
Product name
Ac-YVAD-pNA
Purity
≥95%
Packaging
1mg
Price
$25
Updated
2021/12/16
Cayman Chemical
Product number
17487
Product name
Ac-YVAD-pNA
Purity
≥95%
Packaging
10mg
Price
$125
Updated
2021/12/16
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AC-YVAD-PNA Chemical Properties,Usage,Production

Uses

N-Acetyl-L-tyrosyl-L-valyl-L-alanyl-N-(4-nitrophenyl)-L-α-asparagine is a substrate whose amino acids YVAD have been shown to be a preferred cleavage site for caspase-1 and -4.

Biological Activity

Ac-YVAD-pNA is a very selective chromogenic substrate for caspase-1, a key mediator of inflammatory processes formerly known as interleukin (IL)-1-converting enzyme. Ac-YVAD-pNA is used to determine caspase-1 activity. Cleavage of Ac-YVAD-pNA by caspase-1 releases pNA (p-nitroanilide), which can be quantified spectrophotometrically at 405 nm.

IC 50

Caspase-1

AC-YVAD-PNA Preparation Products And Raw materials

Raw materials

Preparation Products

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AC-YVAD-PNA Suppliers

China 96 Germany 1 Switzerland 2 United Kingdom 3 United States 18 Global 120
GL Biochem (Shanghai) Ltd
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149231-66-3, AC-YVAD-PNARelated Search:

AC-VDVAD-PNA Z-VAD-FMK CASPASE INHIBITOR3 AC-VEID-AMC Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE Z-YVAD-AFC ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL AC-VDVAD-CHO AC-DEVD-AFC PAC1 AC-DEVD-CHO AC-LEHD-AFC AC-LEU-GLU-THR-ASP-AFC 4-(4-AMINOANILINO)-4-OXOBUTANOIC ACID SUC-TYR-VAL-ALA-ASP-PNA AC-ASP-PNA AC-YVAD-PNA AC-YVAD-CHO

  • AC-TYR-VAL-ALA-ASP-PNA
  • N-ACETYL-TYR-VAL-ALA-ASP-P-NITROANILIDE PNA
  • N-acetyl-tyr-val-ala-asp P-nitroanilide
  • AC-TYR-VAL-ALA-ASP-PNA: AC-YVAD-PNA
  • REF DUPL: Ac-Tyr-Val-Ala-Asp-pNA
  • CASPASE-1 SUBSTRATE IV, COLORIMETRIC
  • CASPASE-1 SUBSTRATE (CHROMOGENIC)
  • CASPASE 1 (ICE) SUBSTRATE 2, CHROMOGENIC
  • ICE SUBSTRATE IV
  • IL-1B CONVERTING ENZYME SUBSTRATE IV
  • IL-1BETA CONVERTING ENZYME (ICE) COLORIMETRIC SUBSTRATE
  • ACETYL-TYR-VAL-ALA-ASP-(P-NITROANILIDE)
  • ACETYL-YVAD-PNA
  • AC-YVAD-PNA
  • N-Acetyl-L-tyrosyl-L-valyl-L-alanyl-N-(4-nitrophenyl)-L-α-asparagine
  • N-Acetyl-L-tyrosyl-L-valyl-L-alanyl-N-(4-nitrophenyl)-L-a-asparagine
  • AC-TYR-VAL-ALA-ASP-PARANITROANILIDE
  • Caspase-1 Substrate IV
  • L-α-Asparagine, N-acetyl-L-tyrosyl-L-valyl-L-alanyl-N-(4-nitrophenyl)-
  • Caspase 1 (ICE) Substrate 2, chromogenic - 5 mg
  • 149231-66-3
  • C29H36N6O10
  • Caspase/Related Products
  • Pepetides
  • Peptide