ChemicalBook > CAS DataBase List > 4-Hydroxymethylthiazole

4-Hydroxymethylthiazole

Product Name: 4-Hydroxymethylthiazole
CAS No.: 7036-04-6
Chemical Name: 4-Hydroxymethylthiazole
Synonyms: 4-Thiazolemethanol;THIAZOLE-4-METHANOL;4-Hydroxymethylthiaz;4-HYDROXYMETHYLTHIAZOLE;1,3-THIAZOL-4-YLMETHANOL;4-(Hydroxymethyl)-1,3-thiazole;4-(Hydroxymethyl)-1,3-thiazole95%;4-(Hydroxymethyl)-1,3-thiazole 95%;4-HydroxyMethylthiazole CAS7036-04-6
CBNumber: CB9672002
Molecular Formula: C4H5NOS
Formula Weight: 115.15
MOL File: 7036-04-6.mol

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4-Hydroxymethylthiazole Property

Melting point:: 112-114 °C(Solv: ethyl ether (60-29-7); ethanol (64-17-5))
Boiling point:: 85-90/0.5mm
Density: 1.339±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
form: liquid
pka: 13.21±0.10(Predicted)
color: colourless
InChI: InChI=1S/C4H5NOS/c6-1-4-2-7-3-5-4/h2-3,6H,1H2
InChIKey: WQVOUANKVCYEIQ-UHFFFAOYSA-N
SMILES: S1C=C(CO)N=C1
CAS DataBase Reference: 7036-04-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 37/38-41
Safety Statements: 26-39
Hazard Note: Irritant
HS Code: 2934100090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Matrix Scientific

Product number: 069454
Product name: 4-(Hydroxymethyl)thiazole
Purity: 97%
Packaging: 1g
Price: $72
Updated: 2021/12/16

Apolloscientific

Product number: OR5598
Product name: 4-(Hydroxymethyl)-1,3-thiazole
Purity: 95%
Packaging: 1g
Price: $145
Updated: 2021/12/16

SynQuest Laboratories

Product number: 8H01-1-04
Product name: 4-(Hydroxymethyl)-1,3-thiazole
Purity: 95%
Packaging: 1g
Price: $160
Updated: 2021/12/16

AK Scientific

Product number: X0268
Product name: 4-Hydroxymethylthiazole
Packaging: 5g
Price: $289
Updated: 2021/12/16

Apolloscientific

Product number: OR5598
Product name: 4-(Hydroxymethyl)-1,3-thiazole
Purity: 95%
Packaging: 5g
Price: $363
Updated: 2021/12/16

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4-Hydroxymethylthiazole Chemical Properties,Usage,Production

Chemical Properties

Off-yellow oily liquid

Uses

4-Hydroxymethylthiazole is mainly used as a pharmaceutical intermediate.

Synthesis

14527-43-6

7036-04-6

The general procedure for the synthesis of 4-hydroxymethylthiazole from ethyl 4-thiazolecarboxylate was as follows: - Lithium aluminum hydride (1M tetrahydrofuran solution, 1.5 mL) was slowly added dropwise to a stirred tetrahydrofuran solution (4 mL) of ethyl 4-thiazolecarboxylate (224 mg) at 0 °C. - The reaction mixture was naturally warmed to room temperature with stirring for 1 hour. - Ethyl acetate (20 mL), water (1 mL), 2M sodium hydroxide solution (2 mL), and water (3 mL) were added sequentially to the reaction mixture. - The precipitate formed was removed by filtration through diatomaceous earth (iT). - The filtrate was concentrated to give 4-hydroxymethylthiazole (150 mg, 92% yield). - Nuclear magnetic resonance hydrogen spectroscopy (DMSO-d6) data: δ 4.12 (s, 2H), 7.47 (s, 1H), 9.03 (s, 1H).

References

[1] Patent: WO2005/61465, 2005, A1. Location in patent: Page/Page column 62
[2] European Journal of Medicinal Chemistry, 2018, vol. 154, p. 367 - 391

4-Hydroxymethylthiazole Preparation Products And Raw materials

Raw materials

Preparation Products

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4-HydroxyMethylthiazole CAS7036-04-6

4-(Hydroxymethyl)-1,3-thiazole95%

THIAZOLE-4-METHANOL

1,3-THIAZOL-4-YLMETHANOL

4-HYDROXYMETHYLTHIAZOLE

4-(Hydroxymethyl)-1,3-thiazole

4-(Hydroxymethyl)-1,3-thiazole 95%

4-Thiazolemethanol

7036-04-6

4/6/7036

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7036-4-6

blocks

Thiazoles