Ginsenoside Rg3
- Product Name
- Ginsenoside Rg3
- CAS No.
- 14197-60-5
- Chemical Name
- Ginsenoside Rg3
- Synonyms
- Rg3;CS-1328;gensenoside RG3;GINSENOSIDE RG3;opyransoyl)oxy)-;(20S)-PROPANAXADIOL;20S-Ginseniside Rg3;GINSENOSIDE Rg3(SH);Ginsenosides rg3(s);Ginsenoside Rg3 (S-)
- CBNumber
- CB9713141
- Molecular Formula
- C42H72O13
- Formula Weight
- 785.03
- MOL File
- 14197-60-5.mol
Ginsenoside Rg3 Property
- Melting point:
- 315-318°C
- Boiling point:
- 885.0±65.0 °C(Predicted)
- Density
- 1.30
- storage temp.
- 2-8°C
- solubility
- DMSO: ≥5mg/mL
- pka
- 12.85±0.70(Predicted)
- form
- powder
- color
- white to beige
- optical activity
- [α]/D +10 to +20°, c = 1 in methanol
- InChIKey
- RWXIFXNRCLMQCD-JBVRGBGGSA-N
- CAS DataBase Reference
- 14197-60-5(CAS DataBase Reference)
N-Bromosuccinimide Price
- Product number
- SML0184
- Product name
- Ginsenoside Rg3
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $128
- Updated
- 2024/03/01
- Product number
- 64139
- Product name
- Ginsenoside Rg3
- Purity
- analytical standard
- Packaging
- 10mg
- Price
- $396
- Updated
- 2024/03/01
- Product number
- 15332
- Product name
- Ginsenoside Rg3
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 15332
- Product name
- Ginsenoside Rg3
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- SML0184
- Product name
- Ginsenoside Rg3
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $531
- Updated
- 2024/03/01
Ginsenoside Rg3 Chemical Properties,Usage,Production
Description
Ginsenosides are pharmacologically active natural constituents of ginseng and other plants of the genus Panax. Structurally, they are steroid glycosides derived from the triterpene squalene. Ginsenoside Rg3 is a panaxadiol found in white and red P. ginseng. This ginsenoside has diverse in vitro and in vivo effects, including anti-
Uses
Ginsenoside Rg3 has been used to investigate its modulatory effects on delayed rectifier potassium current (IKr) channels in long QT syndrome (LQTS)2-human induced pluripotent stem cells (hiPSC-CMs).
Uses
Ginsenoside Rg3 shows a synergistic antitumor effect with cisplatin in cisplatin-resistant bladder tumor cell lines and is considered to be an anti-tumor agent.
Definition
ChEBI: (20S)-ginsenoside Rg3 is a ginsenoside found in Panax ginseng and Panax japonicus var. major that is dammarane which is substituted by hydroxy groups at the 3beta, 12beta and 20 pro-S positions, in which the hydroxy group at position 3 has been converted to the corresponding beta-D-glucopyranosyl-beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position. It has a role as an apoptosis inducer, an antineoplastic agent, a plant metabolite and an angiogenesis modulating agent. It is a ginsenoside, a tetracyclic triterpenoid and a glycoside. It is functionally related to a (20S)-protopanaxadiol. It derives from a hydride of a dammarane.
Biochem/physiol Actions
Ginsenoside Rg3 is a natural product isolated from Panax ginseng. Similar to other ginsenosides it exhibits cardio protective effects. Ginsenoside Rg3 enhances cardiac, hERG (IKr) and KCNQ (Iks), channel currents by interaction with the channel pore entryway. It also inhibits the palmitate-induced apoptosis of MIN6N8 mouse insulinoma beta-cells through modulating p44/42 MAPK activation. Ginsenoside Rg3 increases the level of the transcription factor Nrf2 and induces the mRNA levels of multidrug resistance-associated protein (Mrp) 1 and Mrp3. Rg3 modulate neuroinflammation by attenuating the activation of microglia in response to systemic LPS treatment. It activates AMPK in HepG2 cells and reduces the lipid accumulation thereby decreasing the risk of cardiovascular disease due to dyslipidemia.
Ginsenoside Rg3 Preparation Products And Raw materials
Raw materials
Preparation Products
Ginsenoside Rg3 Suppliers
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View Lastest Price from Ginsenoside Rg3 manufacturers
- Product
- Ginsenoside Rg3 14197-60-5
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 2000ton
- Release date
- 2023-08-21
- Product
- Ginsenoside Rg3 14197-60-5
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- ≥96%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2019-10-29
- Product
- Ginsenoside Rg3 14197-60-5
- Price
- US $80.00/g
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 50kg
- Release date
- 2020-03-04