(R)-1-BOC-3-(Hydroxymethyl)piperazine

Product Name: (R)-1-BOC-3-(Hydroxymethyl)piperazine
CAS No.: 278788-66-2
Chemical Name: (R)-1-BOC-3-(Hydroxymethyl)piperazine
Synonyms: tert-butyl (R)-3-(hydroxymethyl)piperazine-1-carboxylate;(R)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate;tert-butyl (3R)-3-(hydroxymethyl)piperazine-1-carboxylate;tert-Butyl (3R)-3-(hydroxymethyl)-1-piperazinecarboxylate;H57159;(3R)-3-(hydroxymethyL;PIPERAZINE-1-CARBOXYLIC;(R)-4-N-Boc-2-hydroxyMeth...;(3R)-3-(Hydroxymethyl)piperazine;(R)-4-Boc-2-hydroxymethyl-piperazine
CBNumber: CB9715509
Molecular Formula: C10H20N2O3
Formula Weight: 216.28
MOL File: 278788-66-2.mol

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(R)-1-BOC-3-(Hydroxymethyl)piperazine Property

Melting point:: 68-70°C
Boiling point:: 322.9±22.0 °C(Predicted)
Density: 1.085±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 14.97±0.10(Predicted)
color: White to Off-White
InChI: InChI=1S/C10H20N2O3/c1-10(2,3)15-9(14)12-5-4-11-8(6-12)7-13/h8,11,13H,4-7H2,1-3H3/t8-/m1/s1
InChIKey: NSILYQWHARROMG-MRVPVSSYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCN[C@@H](CO)C1
CAS DataBase Reference: 278788-66-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 41-52
Safety Statements: 26-39
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SYX00408
Product name: (R)-1-BOC-3-(Hydroxymethyl)piperazine
Packaging: 1g
Price: $461
Updated: 2024/03/01

Activate Scientific

Product number: AS3141
Product name: (R)-1-Boc-(3-Hydroxymethyl)piperazine
Purity: 95+% ee
Packaging: 25g
Price: $476
Updated: 2021/12/16

AK Scientific

Product number: X4711
Product name: (R)-3-Hydroxymethyl-piperazine-1-carboxylicacidtert-butylester
Packaging: 10g
Price: $517
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CCH0037750
Product name: (R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
Purity: 95.00%
Packaging: 1G
Price: $526
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB151258
Product name: (R)-4-N-Boc-2-hydroxymethyl-piperazine
Packaging: 2g
Price: $619
Updated: 2021/12/16

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(R)-1-BOC-3-(Hydroxymethyl)piperazine Chemical Properties,Usage,Production

Uses

(R)-1-Boc-3-hydroxymethylpiperazine is a used as a building block for the preparation of PI3K inhibitors for rheumatoid arthritis treatment,benzoxaborole derivatives as antimalarial agents and anti-tuberculosis agents.

Synthesis

1,4-bis-Boc-2-hydroxymethylpiperazine (13.9 kg) and 95% ethanol (30 kg) were added to the reactor, followed by the addition of an aqueous solution (water 21 kg) of configured sodium hydroxide (3.5 kg). The reaction mixture was then heated to reflux. Once the reaction was completed, ethanol was concentrated under reduced pressure. Subsequently, 30 kg of dichloromethane was added and the mixture was separated into liquid and aqueous phases. The aqueous phase was extracted three times with 3 × 20 kg of dichloromethane, and the organic phases were combined. The resulting solution was washed once with 40 kg of a 15% aqueous sodium chloride solution and dried with anhydrous sodium sulfate. Further purification was carried out to obtain (R)-1-BOC-3-(Hydroxymethyl)piperazine.

(R)-1-BOC-3-(Hydroxymethyl)piperazine Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-1-BOC-3-(Hydroxymethyl)piperazine Suppliers

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View Lastest Price from (R)-1-BOC-3-(Hydroxymethyl)piperazine manufacturers

Zibo Hangyu Biotechnology Development Co., Ltd

Product: (R)-1-BOC-3-(Hydroxymethyl)piperazine 278788-66-2
Price: US $98.00-990.00/g
Min. Order: 5g
Purity: 98%
Supply Ability: 50
Release date: 2024-07-12

Career Henan Chemical Co

Product: (R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 278788-66-2
Price: US $8.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-08-05

278788-66-2, (R)-1-BOC-3-(Hydroxymethyl)piperazineRelated Search:

N-BOC-(3S,4S)-3,4-PYRROLIDINEDIOL (S)-4-N-Boc-piperazine-2-carboxylic acid methyl ester (R)-N-Boc-piperazine-2-carboxylic acid methyl ester (S)-1-Boc-3-hydroxymethyl-piperazine exo-3-Boc-3-azabicyclo[3.1.0]hexane-6-methanol 3-N-Boc-Cis-Tetrahydrofuran-3,4-Diamine tert-butyl (3S)-3-(hydroxymethyl)-2-azabicyclo[3.1.0]hexane-2-carboxylate (6R,7S)-2-BOC-2-AZA-BICYCLO[2.2.1]HEPT-5-EN-3-ONE (2S,4R)-4-hydroxy-2-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester rel-(3r,4r)-3-(boc-amino)-5-fluoropiperidine tert-butyl ((3R,4R)-4-hydroxytetrahydro-2H-pyran-3-yl)carbamate tert-butyl (3R,4S)-3-amino-4-methylpyrrolidine-1-carboxylate tert-butyl (3R)-3-aMino-4-(hydroxyMethyl)pyrrolidine-1-carboxyla (R)-tert-butyl 4-(1-aminoethyl)piperidine-1-carboxylate 1-Pyrrolidinecarboxylicacid,3-(methylamino)-,1,1-dimethylethylester,(R)-(9CI) (R)-N-Boc-3-(aminomethyl)pyrrolidine (R)-1-Boc-3-(Cyanomethyl)Piperidine tert-butyl (2R,3S)-2-(3-aminopropyl)-3-((tert-butyldimethylsilyl)oxy)piperidine-1-carboxylate

(3R)-3-(Hydroxymethyl)piperazine, N1-BOC protected 98%

tert-Butyl (3R)-3-(hydroxymethyl)-1-piperazinecarboxylate

(R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

(R)-4-N-BOC-2-HYDROXYMETHYL-PIPERAZINE

(R)-1-Boc-3-hydroxymethyl-piperazine

(R)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate

H57159

(R)-4-Boc-2-hydroxymethyl-piperazine

1-Piperazinecarboxylic acid, 3-(hydroxymethyl)-, 1,1-dimethylethyl ester, (3R)-

(R)-1-Boc-3-(Hydroxymethyl)piperazine ,98%

tert-butyl (3R)-3-(hydroxymethyl)piperazine-1-carboxylate

(R)-4-N-Boc-2-hydroxyMeth...

(R)-1-Boc-3-(hyroxyMethyl)piperazine

(3R)-3-(Hydroxymethyl)piperazine, N1-BOC protected

tert-Butyl (3R)-3-(hydroxymethyl)piperazine-1-carboxylate, (3R)-1-(tert-Butoxycarbonyl)-3-(hydroxymethyl)piperazine

(3R)-1-Boc-3-(hydroxyMethyl)-piperazine

tert-butyl (R)-3-(hydroxymethyl)piperazine-1-carboxylate

(3R)-3-(hydroxymethyL

(3R)-3-(Hydroxymethyl)piperazine

ert-butyl(3R)-3-(hydroxymethyl)piperazine-1-carboxylate

PIPERAZINE-1-CARBOXYLIC

(3R)-3-(hydroxymethyl)-1-Piperazinecarboxylic acid tert-butyl ester

278788-66-2

pharmacetical

Piperaizine

1