4'-(Trifluoromethyl)acetophenone

Synthesis

Product Name: 4'-(Trifluoromethyl)acetophenone
CAS No.: 709-63-7
Chemical Name: 4'-(Trifluoromethyl)acetophenone
Synonyms: 4-(TRIFLUOROMETHYL)ACETOPHENONE;1-(4-Trifluoromethyl-phenyl)-ethanone;NSC 88346;4-Acetylbe;4-ACETYLBENZOFLUORIDE;On the trifluoroMethyl;4-ACETYLBENZOTRIFLUORIDE;P-TRIFLUOROMETHYLACETOPHENONE;4-(trifluromethyl)acetophenone;4-TRIFLUOROMETHYL BENZYLDEHYDE
CBNumber: CB9717518
Molecular Formula: C9H7F3O
Formula Weight: 188.15
MOL File: 709-63-7.mol

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4'-(Trifluoromethyl)acetophenone Property

Melting point:: 30-33 °C(lit.)
Boiling point:: 79-80 °C8 mm Hg(lit.)
Density: 0.92
refractive index: 1.4604
Flash point:: 184 °F
storage temp.: Sealed in dry,Room Temperature
form: Low Melting Solid
color: White to faintly yellow
BRN: 1870425
CAS DataBase Reference: 709-63-7(CAS DataBase Reference)
NIST Chemistry Reference: 4-CF3-C6H4-COCH3(709-63-7)

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Safety

Hazard Codes: Xi,F
Risk Statements: 36/37/38-11
Safety Statements: 26-36-37/39-16
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29147090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 233188
Product name: 4′-(Trifluoromethyl)acetophenone
Purity: 98%
Packaging: 25g
Price: $112.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: 233188
Product name: 4′-(Trifluoromethyl)acetophenone
Purity: 98%
Packaging: 5g
Price: $120
Updated: 2024/03/01

TCI Chemical

Product number: T1784
Product name: 4'-(Trifluoromethyl)acetophenone
Purity: >98.0%(GC)
Packaging: 1g
Price: $16
Updated: 2024/03/01

TCI Chemical

Product number: T1784
Product name: 4'-(Trifluoromethyl)acetophenone
Purity: >98.0%(GC)
Packaging: 5g
Price: $41
Updated: 2024/03/01

Alfa Aesar

Product number: A15529
Product name: 4'-(Trifluoromethyl)acetophenone, 98+%
Packaging: 5g
Price: $93.65
Updated: 2024/03/01

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4'-(Trifluoromethyl)acetophenone Chemical Properties,Usage,Production

Synthesis

41.6 g of chlorocyclohexane (0.35 mol) were added dropwise to a suspension of 4.65 g of lithium particles (0.68 mol) in 350 g of THF at -55 °C, and an addition time of 2 hours was chosen. After >97% chlorocyclohexane conversion by GC (10 hours), a mixture of 38.3 g of 4-bromotrifluorotoluene (0.170 mol) and 7.0 g of acetonitrile (0.170 mol) was added dropwise at the same temperature for 15 minutes. After stirring for an additional 30 minutes at -50°C, the reaction mixture was slowly thawed to room temperature and subjected to an aqueous workup in a conventional manner. The yield of 4-trifluoromethylacetophenone after distillation was 81%.

Chemical Properties

White to faintly yellow low melting solid

Uses

A labelled acetophenone with selective antimycobacterial activity.

General Description

The enantioselective addition of dialkylzinc to 4′-(trifluoromethyl)acetophenone mediated by 1,2-bis(hydroxycamphorsulfonamido)cyclohexenes in the presence of titanium tetraisopropoxide has been investigated. Phosphorescence emission spectra of 4′-(trifluoromethyl)acetophenone has been studied using pulsed source phosphorimetry.

Purification Methods

Purify the ketone by distillation or sublimation in vacuo.[Beilstein 7 IV 1404.]

4'-(Trifluoromethyl)acetophenone Preparation Products And Raw materials

Raw materials

Preparation Products

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4'-(Trifluoromethyl)acetophenone Suppliers

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View Lastest Price from 4'-(Trifluoromethyl)acetophenone manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 4'-(Trifluoromethyl)acetophenone 709-63-7
Price: US $0.00-0.00/KG
Min. Order: 10mg
Purity: 99%
Supply Ability: 2000tons
Release date: 2020-01-16

Shanghai Rlavie Technology Co ltd

Product: 4-(Trifluoromethyl)acetophenone 709-63-7
Price: US $0.00-0.00/KG
Min. Order: 1g
Purity: 98%min
Supply Ability: 100kgs/month
Release date: 2021-11-26

Qiuxian Baitai New Material Co., LTD

Product: 4'-(TrifluoroMet 709-63-7
Price: US $10.80/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500ton/Month
Release date: 2021-07-29

709-63-7, 4'-(Trifluoromethyl)acetophenoneRelated Search:

4-Trifluoromethylphenol 4-Fluoroacetophenone 3'-Methylacetophenone Trifluoromethanesulfonic anhydride Phenylhydrazine 3-（trifluoromethyl) Cinnamaldehyde 3-(Trifluoromethyl)benzaldehyde Trifluoroacetophenone 4-Trifluoromethylphenylboronic acid 4-(TRIFLUOROMETHYL)PHENYLACETONITRILE (Trifluoromethyl)trimethylsilane Chalcone PHENYL VALERATE Acetophenone 4'-Methylacetophenone 4'-Bromoacetophenone 4'-Hydroxyacetophenone Trifluoro-p-tolunitrile

1-(4-Trifluoromethyl-phenyl)-ethanone

1-[4-(Trifluoromethyl)phenyl]ethanone

Ethanone, 1-[4-(trifluoromethyl)phenyl]-

1-[4-(Trifluoromethyl)phenyl]ethan-1-one

4-(TRIFLUOROMETHYL)ACETOPHENONE

4-ACETYLBENZOFLUORIDE

4-ACETYLBENZOTRIFLUORIDE

P-TRIFLUOROMETHYLACETOPHENONE

4'-(Trifluoromethyl)acetophenone,98%

4-(trifluoromehtyl)acetophenone

4'-(Trifluoromethyl)acetophenone 98%

4'-(Trifluoromethyl)acetophenone,99%

4-Acetylbe

4-(trifluromethyl)acetophenone

1-ó4-(Trifluoromethyl)phenyl!ethan-1-one, 97%

4′-(Trifluoromethyl)acetophenone,4-Acetylbenzotrifluoride

p-Trifluoromethylacetophenone, min. 98%

4-TRIFLUOROMETHYL BENZYLDEHYDE

(4-TrifluoroMethylphenyl) Methyl Ketone

1-[4-(TrifluoroMethyl)phenyl]-1-ethanone

1-Acetyl-4-(trifluoroMethyl) benzene

NSC 88346

On the trifluoroMethyl

1-[4-(Trifluoromethyl)phenyl]ethan-1-one, 4-Acetylbenzotrifluoride

4'-(TrifluoroMethyl)acetophenone, 97+%

4′-(trifuoromethyl)acetophenone

4'-(Trifluoromethyl)acetophenone

709-63-7

706-63-7

CF3C6H4COCH3

Aromatic Acetophenones & Derivatives (substituted)

ketone

Trifluoromethylbenzene serise

Aromatics

bc0001