BUTYROLACTONE I
- Product Name
- BUTYROLACTONE I
- CAS No.
- 87414-49-1
- Chemical Name
- BUTYROLACTONE I
- Synonyms
- OloMoucin;BUTYROLACTONE I;Butyrolactone I - CAS 87414-49-1;2,5-Dihydro-4-hydroxy-2-[4-hydroxy-3-(3-methyl-2-butenyl)benzyl]-3-(4-hydroxyphenyl)-5-oxofuran-2-carboxylic acid methyl ester;2-Furancarboxylic acid, 2,5-dihydro-4-hydroxy-2-[[4-hydroxy-3-(3-methyl-2-buten-1-yl)phenyl]methyl]-3-(4-hydroxyphenyl)-5-oxo-, methyl ester, (2R)-
- CBNumber
- CB9717987
- Molecular Formula
- C24H24O7
- Formula Weight
- 424.44
- MOL File
- 87414-49-1.mol
BUTYROLACTONE I Property
- Melting point:
- 74℃
- Boiling point:
- 660.1±55.0 °C(Predicted)
- Density
- 1.353±0.06 g/cm3(Predicted)
- RTECS
- LU0221600
- storage temp.
- Store at -20°C
- solubility
- Soluble in ethanol at 25mg/ml or DMSO at 10mg/ml
- form
- White solid.
- pka
- 8.59±0.40(Predicted)
- color
- White to off-white
- Sensitive
- Light Sensitive
Safety
- HS Code
- 29419000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 203988
- Product name
- Butyrolactone I - CAS 87414-49-1 - Calbiochem
- Purity
- A cell-permeable and highly selective inhibitor of cyclin-dependent protein kinases (Cdks) that inhibits cell cycle progression at the G?/S and G?/M transitions.
- Packaging
- 200μG
- Price
- $251
- Updated
- 2023/06/20
- Product number
- J67151
- Product name
- Butyrolactone I, 98%
- Packaging
- 200microg
- Price
- $162
- Updated
- 2021/12/16
- Product number
- 21765
- Product name
- Butyrolactone I
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $186
- Updated
- 2024/03/01
- Product number
- 21765
- Product name
- Butyrolactone I
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $556
- Updated
- 2024/03/01
- Product number
- B161388
- Product name
- ButyrolactoneI
- Packaging
- 200μg
- Price
- $90
- Updated
- 2021/12/16
BUTYROLACTONE I Chemical Properties,Usage,Production
Uses
Butyrolactone I is one of a family of three butyrolactones isolated from Aspergillus fumigatus, first reported in 1983. Butyrolactone I exhibits antitumor activity, inhibiting the cell cycle at the G1/S and G2/M transitions. Butyrolactone I is a selective inhibitor of cyclin-dependent kinases CDK1/cyclin B, CDK2 and CDK5, and is an important bioprobe for understanding the cellular roles of CDKs.
Enzyme inhibitor
This natural product (FW = 424.45 g/mol), first identified in species of Aspergillus and named systematically as 2,5-dihydro-4-hydroxy 2-([4- hydroxy-3-(3-methyl-2-butenyl)phenyl]methyl)-3-(4-hydroxyphenyl)-5-oxo- 2-furancarboxylic acid methyl ester, competes with ATP in cyclindependent kinase reactions. The IC50 values for these kinases are typically 0.6-1.5 μM. Butyrolactone I also inhibits cell proliferation by the inhibiting pRb phosphorylation in IMR32 cells, causing both G1 and G2 arrest and stimulating apoptosis. Target(s): cyclin-dependent kinases 1 and 2; cdk5; protein kinase C; protein kinase A; MAP kinase; casein kinase II; [tau protein] kinase.
storage
+4°C
BUTYROLACTONE I Preparation Products And Raw materials
Raw materials
Preparation Products
BUTYROLACTONE I Suppliers
- Tel
- 44-20819178-90 02081917890
- Fax
- (0)2080432064
- info@novachemistry.com
- Country
- United Kingdom
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- Advantage
- 58
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- Country
- United Kingdom
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