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PPADS TETRASODIUM SALT

Product Name
PPADS TETRASODIUM SALT
CAS No.
149017-66-3
Chemical Name
PPADS TETRASODIUM SALT
Synonyms
PPADS;C13745;PPADS tetrasodium sa;PPADS TETRASODIUM SALT;PPADS Tetrasodium Salt（149017-66-3）;PPADS, P2 purinergic receptor antagonist;pyridoxalphosphate-6-azophenyl-2’,4’-disulfonicacid;5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acid;PYRIDOXALPHOSPHATE-6-AZOPHENYL-2',4'-DISULPHONIC ACID 4NA;PYRIDOXAL-PHOSPHATE-6-AZOPHENYL-2',4'-DISULPHONIC ACID TETRASODIUM
CBNumber
CB9729515
Molecular Formula
C14H14N3O12PS2
Formula Weight
511.38
MOL File
149017-66-3.mol
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PPADS TETRASODIUM SALT Property

storage temp. 
−20°C
solubility 
H2O: >10 mg/mL
form 
solid
color 
red to orange
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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PPADS TETRASODIUM SALT Chemical Properties,Usage,Production

Uses

PPADS is a P2 receptor antagonist, with IC50s of 68 nM (P2X1) and 214 nM (P2X3). PPADS acts as an ATP (nucleotide) mimetic and competes with ATP for its binding site on P2 receptors. PPADS is also a reversible competitive antagonist of the NAADP receptor. PPADS reverses nociceptive hypersensitivity and reduces the increased NO/NOS system and IL-1β in both peripheral and central steps of nervous system[1][2][3].

Definition

ChEBI: An arenesulfonic acid that is pyridoxal 5'-phosphate carrying an additional 2,4-disulfophenylazo substituent at position 6.

Biological Activity

A non-selective P2 purinergic antagonist. Blocks recombinant P2X 1 , P2X 2 , P2X 3 , P2X 5 (IC 50 = 1 - 2.6 μ M), native P2Y 2 -like (IC 50 ~ 0.9 mM), and recombinant P2Y 4 (IC 50 ~ 15 mM) receptors.

IC 50

p2x1 Receptor: 68 nM (IC50); P2X2 Receptor: 214 nM (IC50)

References

[1] Billington RA, et al. PPADS is a reversible competitive antagonist of the NAADP receptor. Cell Calcium. 2007 Jun;41(6):505-11. DOI:10.1016/j.ceca.2006.10.002
[2] Brown SG, et al. Actions of a Series of PPADS Analogs at P2X1 and P2X3 Receptors. Drug Dev Res. 2001 Aug;53(4):281-291. DOI:10.1002/ddr.1197
[3] Martucci C, et al. The purinergic antagonist PPADS reduces pain related behaviours and interleukin-1 beta, interleukin-6, iNOS and nNOS overproduction in central and peripheral nervous system after peripheral neuropathy in mice. Pain. 2008 Jul;137(1):81-95. DOI:10.1016/j.pain.2007.08.017

PPADS TETRASODIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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PPADS TETRASODIUM SALT Suppliers

China 34 Germany 3 United Kingdom 4 United States 3 Global 44
Ascent Scientific
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4401179829988
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4402030 700 369
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customerservice@ascentscientific.co.uk
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Tocris Bioscience
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MOLEKULA Ltd.
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Fluorochem Ltd
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149017-66-3, PPADS TETRASODIUM SALTRelated Search:

2-Amino-5-hydroxypyridine (2-Aminopyridin-3-yl)methanol 4-Amino-1,3-benzenedisulfonic acid 3-Hydroxypyridine-4-carboxaldehyde Sodium 2-amino-1,4-benzenedisulfonate 2-Amino-1,4-benzenedisulfonic acid Pyridoxal 5'-phosphate monohydrate 3-HYDROXY-5-METHYLPYRIDINE pyridoxal 3-HYDROXY-2,5-DIMETHYLPYRIDINE-4-CARBOXALDEHYDE Pyridoxal phosphate ISO-PPADS TETRASODIUM SALT PPADS TETRASODIUM SALT 4-deoxypyridoxine 6-AMINO-4-METHYLPYRIDIN-3-OL 3-HYDROXY-2-METHYLPYRIDINE-4-CARBOXALDEHYDE PPADS TETRASODIUM SALT 2-AMINOPYRIDINE-4-CARBALDEHYDE

  • 4-[[4-FORMYL-5-HYDROXY-6-METHYL-3-[(PHOSPHONOOXY)METHYL]-2-PYRIDINYL]AZO]-1,3-BENZENEDISULFONIC ACID TETRASODIUM
  • PYRIDOXALPHOSPHATE-6-AZOPHENYL-2',4'-DISULFONIC ACID TETRASODIUM SALT
  • PYRIDOXALPHOSPHATE-6-AZOPHENYL-2',4'-DISULPHONIC ACID 4NA
  • PYRIDOXAL-PHOSPHATE-6-AZOPHENYL-2',4'-DISULPHONIC ACID TETRASODIUM
  • PPADS
  • PPADS TETRASODIUM SALT
  • pyridoxalphosphate-6-azophenyl-2’,4’-disulfonicacid
  • 4-[[4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]-2-pyridinyl]azo]-1,3-benzenedisulfonic acid tetrasodium salt
  • pyridoxal phosphate-6-azo(benzene-2,4-disulfonic acid) tetrasodium salt
  • C13745
  • 5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acid
  • 1,3-Benzenedisulfonic acid, 4-[2-[4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]-2-pyridinyl]diazenyl]-
  • 4-[(2E)-2-[4-formyl-6-methyl-5-oxo-3-(phosphonooxymethyl)pyridin-2-ylidene]hydrazinyl]benzene-1,3-disulfonicaci
  • PPADS tetrasodium sa
  • PPADS, P2 purinergic receptor antagonist
  • PPADS Tetrasodium Salt（149017-66-3）
  • 149017-66-3
  • C14H10N3Na4O12PS
  • C14H14N3O12PS2
  • Purinergics
  • Purinergics P2 receptor