ChemicalBook > CAS DataBase List > MY-5445

MY-5445

Product Name
MY-5445
CAS No.
78351-75-4
Chemical Name
MY-5445
Synonyms
MY-5445;MY 5445;MY5445;MY-5445, 10 mM in DMSO;1-(3-CHLOROANILINO)-4-PHENYLPHTHALAZINE;1-(3-Chloroanilino)-4-phenylphthalazine >1-(3-CHLOROPHENYLAMINO)-4-PHENYLPHTHALAZINE;N-(3-chlorophenyl)-4-phenylphthalazin-1-amine;N-(3-Chlorophenyl)-4-phenyl-1-phthalazinamine;1-Phthalazinamine, N-(3-chlorophenyl)-4-phenyl-;aggregation,platelet,Inhibitor,anticancer,inhibit,MY5445,neuropathic,MY 5445,Phosphodiesterase (PDE),neuropathic pain,allodynia,MY-5445
CBNumber
CB9739543
Molecular Formula
C20H14ClN3
Formula Weight
331.8
MOL File
78351-75-4.mol
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MY-5445 Property

Boiling point:
539.7±50.0 °C(Predicted)
Density 
1.310±0.06 g/cm3(Predicted)
storage temp. 
Store at RT
solubility 
DMF: 2 mg/ml; DMSO: 2 mg/ml; DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml
pka
4.91±0.30(Predicted)
form 
Yellow solid.
color 
White to Light yellow
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
HS Code 
2933.99.8290
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TCI Chemical
Product number
C2884
Product name
1-(3-Chloroanilino)-4-phenylphthalazine
Purity
>98.0%(GC)
Packaging
20mg
Price
$105
Updated
2024/03/01
TCI Chemical
Product number
C2884
Product name
1-(3-Chloroanilino)-4-phenylphthalazine
Purity
>98.0%(GC)
Packaging
100mg
Price
$358
Updated
2024/03/01
Cayman Chemical
Product number
20872
Product name
MY-5445
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
20872
Product name
MY-5445
Purity
≥98%
Packaging
5mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
20872
Product name
MY-5445
Purity
≥98%
Packaging
10mg
Price
$153
Updated
2024/03/01
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MY-5445 Chemical Properties,Usage,Production

Description

MY-5445 is a selective inhibitor of the cyclic GMP (cGMP) phosphodiesterase, PDE5, with a Ki value of 1.3 μM. It inhibits calcium- and cAMP-selective PDEs with Ki values of >1,000 and 915 μM, respectively. MY-5445 has been shown to relax intact strips of rat aorta with an EC50 value of 4 μM.

Uses

MY-5445 is a selective cGMP phosphodiesterase inhibitor. Potent PDE5 inhibitor.

Definition

ChEBI: N-(3-chlorophenyl)-4-phenyl-1-phthalazinamine is a ring assembly and a member of pyridazines.

Biological Activity

Specific inhibitor of cyclic GMP phosphodiesterase, selective for PDE5 (IC 50 = 0.5 μ M).

MY-5445 Preparation Products And Raw materials

Raw materials

Preparation Products

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MY-5445 Suppliers

Americas 1 China 61 Europe 1 Germany 2 India 1 Italy 1 Japan 3 Switzerland 2 United Kingdom 3 United States 19 Global 94
EMMX Biotechnology LLC
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BIOMOL INTERNATIONAL, LP
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78351-75-4, MY-5445Related Search:

ZARDAVERINE RO 20-1724 BRL 50481 Vinpocetine ZAPRINAST ROLIPRAM Cilostazol (4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE CILOSTAMIDE EHNA HYDROCHLORIDE 3-AMINO-6-METHYLPYRIDAZINE AKOS BB-5445 3-AMINO-6-PHENYLPYRIDAZINE MY-5445 1-AMINOPHTHALAZINE RARECHEM AK PP 5445 AURORA KA-5445 AURORA 5445

  • MY-5445
  • 1-(3-CHLOROPHENYLAMINO)-4-PHENYLPHTHALAZINE
  • 1-(3-CHLOROANILINO)-4-PHENYLPHTHALAZINE
  • N-(3-Chlorophenyl)-4-phenyl-1-phthalazinamine
  • N-(3-chlorophenyl)-4-phenylphthalazin-1-amine
  • MY 5445;MY5445
  • 1-(3-Chloroanilino)-4-phenylphthalazine &gt
  • aggregation,platelet,Inhibitor,anticancer,inhibit,MY5445,neuropathic,MY 5445,Phosphodiesterase (PDE),neuropathic pain,allodynia,MY-5445
  • 1-Phthalazinamine, N-(3-chlorophenyl)-4-phenyl-
  • MY-5445, 10 mM in DMSO
  • 78351-75-4
  • C20H14ClN3
  • Cyclic Nucleotide related